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- GATA_zinc_finger abstract "In molecular biology, GATA zinc fingers are zinc-containing domains found in a number of transcription factors (including erythroid-specific transcription factor and nitrogen regulatory proteins). Some members of this class of zinc fingers specifically bind the DNA sequence (A/T)GATA(A/G) in the regulatory regions of genes., giving rise to the name of the domain. In these domains, a single zinc ion is coordinated by 4 cysteine residues. NMR studies have shown the core of the Znf to comprise 2 irregular anti-parallel beta-sheets and an alpha-helix, followed by a long loop to the C-terminal end of the finger. The N-terminal part, which includes the helix, is similar in structure, but not sequence, to the N-terminal zinc module of the glucocorticoid receptor DNA-binding domain. The helix and the loop connecting the 2 beta-sheets interact with the major groove of the DNA, while the C-terminal tail wraps around into the minor groove. Interactions between the Znf and DNA are mainly hydrophobic, explaining the preponderance of thymines in the binding site; a large number of interactions with the phosphate backbone have also been observed. Two GATA zinc fingers are found in GATA-family transcription factors. However there are several proteins that only contains a single copy of the domain.It is also worth noting that many GATA-type Znfs (such as those found in the proteins GATAD2B and MTA1) have not been experimentally demonstrated to be DNA-binding domains. Furthermore, several GATA-type Znfs have been demonstrated to act as protein-recognition domains. For example, the N-terminal Znf of GATA1 binds specifically to a zinc finger from the transcriptional coregulator FOG1 (ZFPM1).".
- GATA_zinc_finger symbol "GATA".
- GATA_zinc_finger thumbnail PDB_1y0j_EBI.jpg?width=300.
- GATA_zinc_finger wikiPageExternalLink planttfdb.cbi.pku.edu.cn.
- GATA_zinc_finger wikiPageExternalLink family.php?fam=GATA.
- GATA_zinc_finger wikiPageID "32943903".
- GATA_zinc_finger wikiPageLength "4060".
- GATA_zinc_finger wikiPageOutDegree "27".
- GATA_zinc_finger wikiPageRevisionID "654018842".
- GATA_zinc_finger wikiPageWikiLink Alpha_helix.
- GATA_zinc_finger wikiPageWikiLink Beta_sheet.
- GATA_zinc_finger wikiPageWikiLink C-terminus.
- GATA_zinc_finger wikiPageWikiLink Category:Protein_domains.
- GATA_zinc_finger wikiPageWikiLink Cysteine.
- GATA_zinc_finger wikiPageWikiLink GATAD2B.
- GATA_zinc_finger wikiPageWikiLink GATA_transcription_factor.
- GATA_zinc_finger wikiPageWikiLink Gene.
- GATA_zinc_finger wikiPageWikiLink Glucocorticoid_receptor.
- GATA_zinc_finger wikiPageWikiLink Helix.
- GATA_zinc_finger wikiPageWikiLink Ion.
- GATA_zinc_finger wikiPageWikiLink MTA1.
- GATA_zinc_finger wikiPageWikiLink Nitrogen.
- GATA_zinc_finger wikiPageWikiLink Nuclear_magnetic_resonance.
- GATA_zinc_finger wikiPageWikiLink Nucleic_acid_double_helix.
- GATA_zinc_finger wikiPageWikiLink Nucleic_acid_sequence.
- GATA_zinc_finger wikiPageWikiLink Phosphate.
- GATA_zinc_finger wikiPageWikiLink Protein.
- GATA_zinc_finger wikiPageWikiLink Protein_domain.
- GATA_zinc_finger wikiPageWikiLink Red_blood_cell.
- GATA_zinc_finger wikiPageWikiLink Thymine.
- GATA_zinc_finger wikiPageWikiLink Transcription_factor.
- GATA_zinc_finger wikiPageWikiLink Turn_(biochemistry).
- GATA_zinc_finger wikiPageWikiLink ZFPM1.
- GATA_zinc_finger wikiPageWikiLink Zinc.
- GATA_zinc_finger wikiPageWikiLink Zinc_finger.
- GATA_zinc_finger caption "zinc fingers as protein recognition motifs: structural basis for the gata-1/friend of gata interaction".
- GATA_zinc_finger cdd "cd00202".
- GATA_zinc_finger interpro "IPR000679".
- GATA_zinc_finger name "GATA zinc finger".
- GATA_zinc_finger pfam "PF00320".
- GATA_zinc_finger pfamClan "CL0167".
- GATA_zinc_finger prosite "PDOC00300".
- GATA_zinc_finger scop "1".
- GATA_zinc_finger symbol "GATA".
- GATA_zinc_finger wikiPageUsesTemplate Template:Infobox_protein_family.
- GATA_zinc_finger wikiPageUsesTemplate Template:InterPro_content.
- GATA_zinc_finger wikiPageUsesTemplate Template:Orphan.
- GATA_zinc_finger wikiPageUsesTemplate Template:Reflist.
- GATA_zinc_finger subject Category:Protein_domains.
- GATA_zinc_finger hypernym Domains.
- GATA_zinc_finger type Biomolecule.
- GATA_zinc_finger type Protein.
- GATA_zinc_finger type Chemical.
- GATA_zinc_finger type Domain.
- GATA_zinc_finger type Thing.
- GATA_zinc_finger type Q206229.
- GATA_zinc_finger type Q8054.
- GATA_zinc_finger comment "In molecular biology, GATA zinc fingers are zinc-containing domains found in a number of transcription factors (including erythroid-specific transcription factor and nitrogen regulatory proteins). Some members of this class of zinc fingers specifically bind the DNA sequence (A/T)GATA(A/G) in the regulatory regions of genes., giving rise to the name of the domain. In these domains, a single zinc ion is coordinated by 4 cysteine residues.".
- GATA_zinc_finger label "GATA zinc finger".
- GATA_zinc_finger sameAs Q5512900.
- GATA_zinc_finger sameAs m.0h51t05.
- GATA_zinc_finger sameAs Q5512900.
- GATA_zinc_finger wasDerivedFrom GATA_zinc_finger?oldid=654018842.
- GATA_zinc_finger depiction PDB_1y0j_EBI.jpg.
- GATA_zinc_finger isPrimaryTopicOf GATA_zinc_finger.