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- G418 abstract "G418 (Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3'-phosphotransferase, APT 3' II. G418 is commonly used in laboratory research to select genetically engineered cells (typically using the KanMX selectable marker). In general for bacteria and algae concentrations of 5 mg/L or less are used, for mammalian cells concentrations of approximately 400 mg/L are used for selection and 200 mg/L for maintenance. However, optimal concentration for resistant clones selection in mammalian cells depends on the cell line used as well as on the plasmid carrying the resistance gene, therefore antibiotic titration should be done to find the best condition for every experimental system. Titration should be done using antibiotic concentrations ranging from 100 mg/L up to 1400 mg/L. Resistant clones selection could require from 1 to up to 3 weeks.".
- G418 iupacName "(2R,3S,4R,5R,6S)-5-Amino-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-methylaminooxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-".
- G418 iupacName "2-(1-hydroxyethyl)oxane-3,4-diol".
- G418 thumbnail Genetecin.png?width=300.
- G418 wikiPageID "10992237".
- G418 wikiPageLength "5611".
- G418 wikiPageOutDegree "14".
- G418 wikiPageRevisionID "693049048".
- G418 wikiPageWikiLink 3T3_cells.
- G418 wikiPageWikiLink Aminoglycoside.
- G418 wikiPageWikiLink Antibiotics.
- G418 wikiPageWikiLink Category:Aminoglycoside_antibiotics.
- G418 wikiPageWikiLink Eukaryote.
- G418 wikiPageWikiLink Gentamicin.
- G418 wikiPageWikiLink Immortalised_cell_line.
- G418 wikiPageWikiLink Kanamycin.
- G418 wikiPageWikiLink Micromonospora.
- G418 wikiPageWikiLink Plasmid.
- G418 wikiPageWikiLink Prokaryote.
- G418 wikiPageWikiLink Protein_biosynthesis.
- G418 wikiPageWikiLinkText "G418".
- G418 wikiPageWikiLinkText "Geneticin".
- G418 imagefile "Genetecin.png".
- G418 imagesize "250".
- G418 iupacname "-5".
- G418 othernames "Geneticin".
- G418 othernames "O-2-Amino-2,7-didesoxy-(D)-glycero-α-(D)-gluco-heptopyranosyl--O--(D)-streptamin".
- G418 verifiedfields "changed".
- G418 verifiedrevid "461115152".
- G418 watchedfields "changed".
- G418 wikiPageUsesTemplate Template:Cascite.
- G418 wikiPageUsesTemplate Template:Chembox.
- G418 wikiPageUsesTemplate Template:Chembox_Explosive.
- G418 wikiPageUsesTemplate Template:Chembox_Hazards.
- G418 wikiPageUsesTemplate Template:Chembox_Identifiers.
- G418 wikiPageUsesTemplate Template:Chembox_Pharmacology.
- G418 wikiPageUsesTemplate Template:Chembox_Properties.
- G418 wikiPageUsesTemplate Template:Chembox_Related.
- G418 wikiPageUsesTemplate Template:Chembox_Structure.
- G418 wikiPageUsesTemplate Template:Chembox_Thermochemistry.
- G418 wikiPageUsesTemplate Template:Chemspidercite.
- G418 wikiPageUsesTemplate Template:Drugbankcite.
- G418 wikiPageUsesTemplate Template:Ebicite.
- G418 wikiPageUsesTemplate Template:Keggcite.
- G418 wikiPageUsesTemplate Template:LD50.
- G418 wikiPageUsesTemplate Template:Reflist.
- G418 wikiPageUsesTemplate Template:Stdinchicite.
- G418 subject Category:Aminoglycoside_antibiotics.
- G418 type ChemicalCompound.
- G418 type ChemicalSubstance.
- G418 type Chemical.
- G418 type Glycoside.
- G418 type ChemicalObject.
- G418 type Thing.
- G418 type Q11173.
- G418 comment "G418 (Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3'-phosphotransferase, APT 3' II. G418 is commonly used in laboratory research to select genetically engineered cells (typically using the KanMX selectable marker).".
- G418 label "G418".
- G418 sameAs Q410036.
- G418 sameAs Geneticin.
- G418 sameAs جی۴۱۸.
- G418 sameAs Geneticina.
- G418 sameAs G418.
- G418 sameAs m.03bxxt0.
- G418 sameAs G418.
- G418 sameAs G418.
- G418 sameAs Q410036.
- G418 wasDerivedFrom G418?oldid=693049048.
- G418 depiction Genetecin.png.
- G418 isPrimaryTopicOf G418.