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- Follicular_B_helper_T_cells abstract "Follicular B helper T cells (also known as just Follicular helper T cells or TFH), are antigen-experienced CD4+ T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleens and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing receptor CXCR5. Upon cellular interaction and cross-signaling with their cognate follicular (Fo B) B cells, TFH cells trigger the formation and maintenance of germinal centers through the expression of CD40 ligand (CD40L) and the secretion of IL-21 and IL-4. TFH cells also migrate into these seeded germinal centers, predominantly composed of rapidly dividing and mutating B cells. Within germinal centers, TFH cells play a critical role in mediating the selection and survival of B cells that go on to differentiate either into special plasma cells capable of producing high affinity antibodies against foreign antigen, and memory B cells capable of quick immune re-activation in the future if ever the same antigen is re-encountered. TFH cells are also thought to facilitate negative selection of potentially autoimmune-causing mutated B cells in the germinal center. However, the biomechanisms by which TFH cells mediate germinal center tolerance are yet to be fully understood.It is possible that TFH cells might arise as branches in the Th1 and Th2 differentiation pathways but their precise lineage relationship to the other effector CD4+ T cell subsets is still uncertain. Recent studies have however shown that TFH have distinct gene expression profiles, supporting the theory that TFH are a subset of CD4+ T cells distinct from Th-1, Th-2, Th-17 or Tregs.".
- Follicular_B_helper_T_cells wikiPageID "19612999".
- Follicular_B_helper_T_cells wikiPageLength "14960".
- Follicular_B_helper_T_cells wikiPageOutDegree "53".
- Follicular_B_helper_T_cells wikiPageRevisionID "698825540".
- Follicular_B_helper_T_cells wikiPageWikiLink Activation-induced_cytidine_deaminase.
- Follicular_B_helper_T_cells wikiPageWikiLink Affinity_maturation.
- Follicular_B_helper_T_cells wikiPageWikiLink Antigen.
- Follicular_B_helper_T_cells wikiPageWikiLink Autoimmune_disease.
- Follicular_B_helper_T_cells wikiPageWikiLink Autoimmunity.
- Follicular_B_helper_T_cells wikiPageWikiLink BCL6.
- Follicular_B_helper_T_cells wikiPageWikiLink B_cell.
- Follicular_B_helper_T_cells wikiPageWikiLink CD154.
- Follicular_B_helper_T_cells wikiPageWikiLink CD278.
- Follicular_B_helper_T_cells wikiPageWikiLink CD4.
- Follicular_B_helper_T_cells wikiPageWikiLink CXCR5.
- Follicular_B_helper_T_cells wikiPageWikiLink Category:T_cells.
- Follicular_B_helper_T_cells wikiPageWikiLink Cytotoxic_T_cell.
- Follicular_B_helper_T_cells wikiPageWikiLink FOXP3.
- Follicular_B_helper_T_cells wikiPageWikiLink Follicular_B_cell.
- Follicular_B_helper_T_cells wikiPageWikiLink Germinal_center.
- Follicular_B_helper_T_cells wikiPageWikiLink Immunity_(medical).
- Follicular_B_helper_T_cells wikiPageWikiLink Immunization.
- Follicular_B_helper_T_cells wikiPageWikiLink Immunosenescence.
- Follicular_B_helper_T_cells wikiPageWikiLink Interleukin_21.
- Follicular_B_helper_T_cells wikiPageWikiLink Interleukin_4.
- Follicular_B_helper_T_cells wikiPageWikiLink Lymph_node.
- Follicular_B_helper_T_cells wikiPageWikiLink Memory_B_cell.
- Follicular_B_helper_T_cells wikiPageWikiLink Paracrine_signalling.
- Follicular_B_helper_T_cells wikiPageWikiLink Peripheral_tolerance.
- Follicular_B_helper_T_cells wikiPageWikiLink Peyers_patch.
- Follicular_B_helper_T_cells wikiPageWikiLink Plasma_cell.
- Follicular_B_helper_T_cells wikiPageWikiLink Regulatory_T_cell.
- Follicular_B_helper_T_cells wikiPageWikiLink Sjxc3xb6grens_syndrome.
- Follicular_B_helper_T_cells wikiPageWikiLink Somatic_hypermutation.
- Follicular_B_helper_T_cells wikiPageWikiLink Spleen.
- Follicular_B_helper_T_cells wikiPageWikiLink Systemic_lupus_erythematosus.
- Follicular_B_helper_T_cells wikiPageWikiLink T_cell.
- Follicular_B_helper_T_cells wikiPageWikiLink T_helper_17_cell.
- Follicular_B_helper_T_cells wikiPageWikiLink T_helper_cell.
- Follicular_B_helper_T_cells wikiPageWikiLink Vaccine.
- Follicular_B_helper_T_cells wikiPageWikiLink File:Tfh.pdf.
- Follicular_B_helper_T_cells wikiPageWikiLinkText "Follicular B helper T cells".
- Follicular_B_helper_T_cells wikiPageWikiLinkText "follicular B helper T cells".
- Follicular_B_helper_T_cells wikiPageUsesTemplate Template:Lymphocytes.
- Follicular_B_helper_T_cells wikiPageUsesTemplate Template:Reflist.
- Follicular_B_helper_T_cells subject Category:T_cells.
- Follicular_B_helper_T_cells hypernym Cells.
- Follicular_B_helper_T_cells type AnatomicalStructure.
- Follicular_B_helper_T_cells type Cell.
- Follicular_B_helper_T_cells comment "Follicular B helper T cells (also known as just Follicular helper T cells or TFH), are antigen-experienced CD4+ T cells found in the periphery within B cell follicles of secondary lymphoid organs such as lymph nodes, spleens and Peyer's patches, and are identified by their constitutive expression of the B cell follicle homing receptor CXCR5.".
- Follicular_B_helper_T_cells label "Follicular B helper T cells".
- Follicular_B_helper_T_cells sameAs Q5464650.
- Follicular_B_helper_T_cells sameAs m.04n354q.
- Follicular_B_helper_T_cells sameAs Q5464650.
- Follicular_B_helper_T_cells wasDerivedFrom Follicular_B_helper_T_cells?oldid=698825540.
- Follicular_B_helper_T_cells isPrimaryTopicOf Follicular_B_helper_T_cells.