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- Foam_cell abstract "Foam cells are fat-laden macrophages seen in atherosclerosis. They are an indication of plaque build-up, or atherosclerosis, which is commonly associated with increased risk of heart attack and stroke. Foam cells are formed when the body sends macrophages to the location of a fatty deposit on the blood vessel walls. The macrophage surrounds the fatty material in an attempt to destroy it. The cell becomes filled with lipids (fats). The lipids surrounded by the macrophage give it a “foamy” appearance. In chronic hyperlipidemia, lipoproteins aggregate within the intima of blood vessels and become oxidized by the action of oxygen free radicals generated either by macrophages or endothelial cells. The macrophages engulf oxidized low-density lipoproteins (LDLs) by endocytosis via scavenger receptors, which are distinct from LDL receptors. The oxidized LDL accumulates in the macrophages and other phagocytes, which are then known as foam cells. Foam cells form the fatty streaks of the plaques of atheroma in the tunica intima of arteries.Low-density lipoprotein (LDL) cholesterol is contained by a foam cell. LDL is also known as “bad” cholesterol. It becomes a marker for atherosclerosis. Foam cells are the body’s way of trying to get rid of bad cholesterol from the blood vessels. Foam cells do not give off any explicit signs or symptoms, but they are part of the origin of atherosclerosis. Foam cells are very small in size and can only be truly detected by examining a fatty plaque under a microscope after it is removed from the body. HDL cholesterol is good cholesterol and it removes harmful bad cholesterol from where it does not belong.\tFoam cells are not dangerous as such, but can become a problem when they accumulate at particular foci thus creating a necrotic centre of atherosclerosis. If the fibrous cap that prevents the necrotic centre from spilling into the lumen of a vessel ruptures, a thrombus can form which can lead to emboli occluding smaller vessels. The occlusion of small vessels results in ischemia, and contributes to stroke and myocardial infarction, two of the leading causes of cardiovascular-related death.Atherosclerosis is the hardening and narrowing of the arteries, due to the formation of plaques in the blood vessel. Atherosclerosis is the usual cause of heart attacks, strokes, and peripheral vascular disease. Together, these diseases are called “cardiovascular disease.” Foam Cells will form around silicone breast implants as well.Autoimmunity occurs when the body starts attacking itself. The link between atherosclerosis and autoimmunity is plasmacytoid dendritic cells (pDCs). PDCs contribute to the early stages of the formation of atherosclerotic lesions in the blood vessels. Stimulation of pDCs leads to an increase of macrophages present in plaques.".
- Foam_cell thumbnail Gallbladder_cholesterolosis_intermed_mag_cropped.jpg?width=300.
- Foam_cell wikiPageID "5560406".
- Foam_cell wikiPageLength "5090".
- Foam_cell wikiPageOutDegree "23".
- Foam_cell wikiPageRevisionID "703759203".
- Foam_cell wikiPageWikiLink Atherosclerosis.
- Foam_cell wikiPageWikiLink Blood_vessel.
- Foam_cell wikiPageWikiLink Category:Macrophages.
- Foam_cell wikiPageWikiLink Embolus.
- Foam_cell wikiPageWikiLink Endocytosis.
- Foam_cell wikiPageWikiLink Hyperlipidemia.
- Foam_cell wikiPageWikiLink Ischemia.
- Foam_cell wikiPageWikiLink Lipoprotein.
- Foam_cell wikiPageWikiLink Low-density_lipoprotein.
- Foam_cell wikiPageWikiLink Lumen_(anatomy).
- Foam_cell wikiPageWikiLink Macrophage.
- Foam_cell wikiPageWikiLink Myocardial_infarction.
- Foam_cell wikiPageWikiLink Necrosis.
- Foam_cell wikiPageWikiLink Phagocyte.
- Foam_cell wikiPageWikiLink Plasmacytoid_dendritic_cell.
- Foam_cell wikiPageWikiLink Radical_(chemistry).
- Foam_cell wikiPageWikiLink Stroke.
- Foam_cell wikiPageWikiLink Thrombus.
- Foam_cell wikiPageWikiLink Tunica_intima.
- Foam_cell wikiPageWikiLink File:Gallbladder_cholesterolosis_intermed_mag_cropped.jpg.
- Foam_cell wikiPageWikiLinkText "Foam cell".
- Foam_cell wikiPageWikiLinkText "foam cell".
- Foam_cell wikiPageWikiLinkText "foamy macrophages".
- Foam_cell wikiPageUsesTemplate Template:Reflist.
- Foam_cell wikiPageUsesTemplate Template:Vascular_diseases.
- Foam_cell subject Category:Macrophages.
- Foam_cell hypernym Macrophages.
- Foam_cell type AnatomicalStructure.
- Foam_cell comment "Foam cells are fat-laden macrophages seen in atherosclerosis. They are an indication of plaque build-up, or atherosclerosis, which is commonly associated with increased risk of heart attack and stroke. Foam cells are formed when the body sends macrophages to the location of a fatty deposit on the blood vessel walls. The macrophage surrounds the fatty material in an attempt to destroy it. The cell becomes filled with lipids (fats).".
- Foam_cell label "Foam cell".
- Foam_cell sameAs Q1425962.
- Foam_cell sameAs خلية_رغوية.
- Foam_cell sameAs Pěnitá_buňka.
- Foam_cell sameAs Schaumzelle.
- Foam_cell sameAs Célula_espumosa.
- Foam_cell sameAs Cellule_spumeuse.
- Foam_cell sameAs Célula_escumosa.
- Foam_cell sameAs m.025tjgw.
- Foam_cell sameAs Skumcell.
- Foam_cell sameAs Q1425962.
- Foam_cell sameAs 泡沫细胞.
- Foam_cell wasDerivedFrom Foam_cell?oldid=703759203.
- Foam_cell depiction Gallbladder_cholesterolosis_intermed_mag_cropped.jpg.
- Foam_cell isPrimaryTopicOf Foam_cell.