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- Filopodia abstract "Filopodia (also microspikes) are slender cytoplasmic projections that extend beyond the leading edge of lamellipodia in migrating cells. They contain actin filaments cross-linked into bundles by actin-binding proteins, e.g. fascin and fimbrin. Filopodia form focal adhesions with the substratum, linking it to the cell surface. Many types of migrating cells display filopodia, which are thought to be involved in both sensation of chemotropic cues, and resulting changes in directed locomotion.Activation of the Rho family of small Ras-related GTPases, particularly cdc42 and their downstream intermediates results in the polymerization of actin fibers by Ena/Vasp homology proteins. Growth factors bind to receptor tyrosine kinases resulting in the polymerization of actin filaments, which, when cross-linked, make up the supporting cytoskeletal elements of filopodia. Rho activity also results in activation by phosphorylation of ezrin-moesin-radixin family proteins that link actin filaments to the filopodia membrane.Filopodia have roles in sensing, migration and cell-cell interaction. To close a wound in vertebrates, growth factors stimulate the formation of filopodia in fibroblasts to direct fibroblast migration and wound closure. In developing neurons, filopodia extend from the growth cone at the leading edge. In neurons deprived of filopodia by partial inhibition of actin filaments polymerization, growth cone extension continues as normal but direction of growth is disrupted and highly irregular. Filopodia-like projections have also been linked to dendrite creation when new synapses are formed in the brain. In macrophages, filopodia act as phagocytic tentacles and pull bound objects towards the cell for phagocytosis.Filopodia are also used for movement of bacteria between cells, so as to evade the host immune system. The intracellular bacteria Ehrlichia are transported between cells through the host cell filopodia induced by the pathogen during initial stages of infection. Viruses were shown to be transported along filopodia toward the cell body, leading to cell infection. Directed transport of receptor-bound epidermal growth factor (EGF) along filopodia has also been described, supporting the proposed sensing function of filopodia.".
- Filopodia thumbnail Filopodia.jpg?width=300.
- Filopodia wikiPageExternalLink go-0030175.
- Filopodia wikiPageExternalLink go-0046847.
- Filopodia wikiPageExternalLink new-form-of-cinema-cellular-film.html.
- Filopodia wikiPageID "4102360".
- Filopodia wikiPageLength "6520".
- Filopodia wikiPageOutDegree "28".
- Filopodia wikiPageRevisionID "636012918".
- Filopodia wikiPageWikiLink Actin.
- Filopodia wikiPageWikiLink CDC42.
- Filopodia wikiPageWikiLink Category:Actin_based_structures.
- Filopodia wikiPageWikiLink Category:Cell_biology.
- Filopodia wikiPageWikiLink Category:Cell_movement.
- Filopodia wikiPageWikiLink Category:Cytoskeleton.
- Filopodia wikiPageWikiLink Cell_(biology).
- Filopodia wikiPageWikiLink Cytoskeleton.
- Filopodia wikiPageWikiLink Dendrite.
- Filopodia wikiPageWikiLink ERM_protein_family.
- Filopodia wikiPageWikiLink Vasp_homology_proteins.
- Filopodia wikiPageWikiLink Epidermal_growth_factor.
- Filopodia wikiPageWikiLink Fascin.
- Filopodia wikiPageWikiLink Fibroblast.
- Filopodia wikiPageWikiLink Fimbrin.
- Filopodia wikiPageWikiLink GTPase.
- Filopodia wikiPageWikiLink Growth_cone.
- Filopodia wikiPageWikiLink Lamellipodium.
- Filopodia wikiPageWikiLink Macrophage.
- Filopodia wikiPageWikiLink Neuron.
- Filopodia wikiPageWikiLink Phagocytosis.
- Filopodia wikiPageWikiLink Polymerization.
- Filopodia wikiPageWikiLink Pseudopodia.
- Filopodia wikiPageWikiLink Synapse.
- Filopodia wikiPageWikiLink File:Filopodia.jpg.
- Filopodia wikiPageWikiLinkText "Filopodia".
- Filopodia wikiPageWikiLinkText "filopodia".
- Filopodia wikiPageWikiLinkText "filose pseudopods".
- Filopodia wikiPageUsesTemplate Template:Reflist.
- Filopodia subject Category:Actin_based_structures.
- Filopodia subject Category:Cell_biology.
- Filopodia subject Category:Cell_movement.
- Filopodia subject Category:Cytoskeleton.
- Filopodia hypernym Projections.
- Filopodia type AnatomicalStructure.
- Filopodia type Structure.
- Filopodia comment "Filopodia (also microspikes) are slender cytoplasmic projections that extend beyond the leading edge of lamellipodia in migrating cells. They contain actin filaments cross-linked into bundles by actin-binding proteins, e.g. fascin and fimbrin. Filopodia form focal adhesions with the substratum, linking it to the cell surface.".
- Filopodia label "Filopodia".
- Filopodia sameAs Q3772735.
- Filopodia sameAs Filopodi.
- Filopodia sameAs Filopodio.
- Filopodia sameAs Filopodija.
- Filopodia sameAs m.0bj26g.
- Filopodia sameAs Filopod.
- Filopodia sameAs Q3772735.
- Filopodia wasDerivedFrom Filopodia?oldid=636012918.
- Filopodia depiction Filopodia.jpg.
- Filopodia isPrimaryTopicOf Filopodia.