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- Fasciclin_2 abstract "Fasciclin 2 (Fas2 or FasII) is a 95 kilodalton cell membrane glycoprotein in the immunoglobulin (Ig) – related superfamily of cell adhesion molecules (CAMs). It was first identified in the developing grasshopper embryo, seen dynamically expressed on a subset of fasciculating axons in the central nervous system (CNS), functioning as a neuronal recognition molecule in the regulation of selective axon fasciculation. Subsequently, fasII was cloned and has mainly been studied in the fruit fly (Drosophila melanogaster). Its extracellular structure consists of two Fibronectin type III domains and five Ig-like C2 domains, having structural homology to the neural cell adhesion molecule (NCAM) found in vertebrates. Alternative splicing of fasII gives rise to its expression in three major isoforms, including a membrane-associated form that is attached to the outer leaflet of the plasma membrane via a glycophosphatidylinositol (GPI anchor) linkage and two integral transmembrane forms. The larger transmembrane form has an amino acid motif contained in its cytoplasmic domain that is rich in proline, glutamic acid, serine and threonine residues (PEST sequence). The fasciclin 1 (Fas1) and fasciclin 3 (Fas3) genes in Drosophila also code for cell adhesion proteins in the nervous system but do not show any structural or functional similarities with NCAM.FasII is initially expressed selectively localized to basolateral junctions during the process of oogenesis, where it functions to establish polarity in inner polar cells of epithelium-derived border cells. During embryogenesis, fasII is dynamically expressed on a subset of axon fascicles in longitudinal nervous system pathways, including the MP1 tract. Here, fasII (and other attractive/repulsive environmental cues such as semaphorins and other morphogens) functions as a framework for pathfinding choices of newly extending axons. This is achieved through trans-homophilic fasII-mediated adhesion and subsequent activation of downstream intracellular signaling pathways involving mitogen-activated protein kinase (MAPK) and regulation of intracellular calcium levels. Later, fasII is expressed on growth cones of axons in other tracts including embryonic peripheral nervous system (PNS) motor neurons. Only the transmembrane isoforms are expressed by neurons, while the GPI-linked form is expressed by non-neuronal cells (mainly glial cells), where it functions as a substrate for growth cones of extending axons, directing adhesion and axon guidance. FasII is also expressed by clusters of differentiating neuroblasts at early stages of neurogenesis where its function is not fully understood but might be involved in proneural gene induction.Other roles for fasII include delineating two axonal pathways in the adult ocellar sensory system (OSS) via its expression on ocellar pioneer (OP) neurons where it acts to promote neurite outgrowth from primary neurons (along with neuroglian) by activating fibroblast growth factor receptor (FGFR) signaling. In addition, fasII has been shown to be involved in synaptic target selection, stabilization and remodeling along with several proteins such as netrins, semaphorins and other Ig-CAMs.".
- Fasciclin_2 wikiPageID "38707815".
- Fasciclin_2 wikiPageLength "4680".
- Fasciclin_2 wikiPageOutDegree "53".
- Fasciclin_2 wikiPageRevisionID "611279342".
- Fasciclin_2 wikiPageWikiLink Alternative_splicing.
- Fasciclin_2 wikiPageWikiLink Amino_acid.
- Fasciclin_2 wikiPageWikiLink Antibody.
- Fasciclin_2 wikiPageWikiLink Atomic_mass_unit.
- Fasciclin_2 wikiPageWikiLink Axon.
- Fasciclin_2 wikiPageWikiLink Border_cells_(Drosophila).
- Fasciclin_2 wikiPageWikiLink C2_domain.
- Fasciclin_2 wikiPageWikiLink Calcium.
- Fasciclin_2 wikiPageWikiLink Category:Cell_adhesion_molecules.
- Fasciclin_2 wikiPageWikiLink Category:Glycoproteins.
- Fasciclin_2 wikiPageWikiLink Cell_adhesion_molecule.
- Fasciclin_2 wikiPageWikiLink Cell_membrane.
- Fasciclin_2 wikiPageWikiLink Cell_polarity.
- Fasciclin_2 wikiPageWikiLink Cell_signaling.
- Fasciclin_2 wikiPageWikiLink Central_nervous_system.
- Fasciclin_2 wikiPageWikiLink Drosophila_melanogaster.
- Fasciclin_2 wikiPageWikiLink Embryo.
- Fasciclin_2 wikiPageWikiLink Embryogenesis.
- Fasciclin_2 wikiPageWikiLink Epithelium.
- Fasciclin_2 wikiPageWikiLink Extracellular.
- Fasciclin_2 wikiPageWikiLink Fasciclin_1.
- Fasciclin_2 wikiPageWikiLink Fasciclin_3.
- Fasciclin_2 wikiPageWikiLink Fasciclin_domain.
- Fasciclin_2 wikiPageWikiLink Fibroblast_growth_factor_receptor.
- Fasciclin_2 wikiPageWikiLink Fibronectin_type_III_domain.
- Fasciclin_2 wikiPageWikiLink Glutamic_acid.
- Fasciclin_2 wikiPageWikiLink Glycophosphatidylinositol.
- Fasciclin_2 wikiPageWikiLink Glycoprotein.
- Fasciclin_2 wikiPageWikiLink Grasshopper.
- Fasciclin_2 wikiPageWikiLink Growth_cone.
- Fasciclin_2 wikiPageWikiLink Homology_(biology).
- Fasciclin_2 wikiPageWikiLink Intracellular.
- Fasciclin_2 wikiPageWikiLink Mitogen-activated_protein_kinase.
- Fasciclin_2 wikiPageWikiLink Morphogen.
- Fasciclin_2 wikiPageWikiLink Motor_neuron.
- Fasciclin_2 wikiPageWikiLink Netrin.
- Fasciclin_2 wikiPageWikiLink Neural_cell_adhesion_molecule.
- Fasciclin_2 wikiPageWikiLink Neurite.
- Fasciclin_2 wikiPageWikiLink Neuroblast.
- Fasciclin_2 wikiPageWikiLink Neurogenesis.
- Fasciclin_2 wikiPageWikiLink Neuroglia.
- Fasciclin_2 wikiPageWikiLink Neuron.
- Fasciclin_2 wikiPageWikiLink Oogenesis.
- Fasciclin_2 wikiPageWikiLink PEST_sequence.
- Fasciclin_2 wikiPageWikiLink Peripheral_nervous_system.
- Fasciclin_2 wikiPageWikiLink Proline.
- Fasciclin_2 wikiPageWikiLink Protein_isoform.
- Fasciclin_2 wikiPageWikiLink Semaphorin.
- Fasciclin_2 wikiPageWikiLink Serine.
- Fasciclin_2 wikiPageWikiLink Substrate_(chemistry).
- Fasciclin_2 wikiPageWikiLink Threonine.
- Fasciclin_2 wikiPageWikiLink Vertebrate.
- Fasciclin_2 wikiPageWikiLinkText "Fasciclin 2".
- Fasciclin_2 wikiPageUsesTemplate Template:Reflist.
- Fasciclin_2 subject Category:Cell_adhesion_molecules.
- Fasciclin_2 subject Category:Glycoproteins.
- Fasciclin_2 hypernym Glycoprotein.
- Fasciclin_2 type Protein.
- Fasciclin_2 type Glycoprotein.
- Fasciclin_2 comment "Fasciclin 2 (Fas2 or FasII) is a 95 kilodalton cell membrane glycoprotein in the immunoglobulin (Ig) – related superfamily of cell adhesion molecules (CAMs). It was first identified in the developing grasshopper embryo, seen dynamically expressed on a subset of fasciculating axons in the central nervous system (CNS), functioning as a neuronal recognition molecule in the regulation of selective axon fasciculation.".
- Fasciclin_2 label "Fasciclin 2".
- Fasciclin_2 sameAs Q17145056.
- Fasciclin_2 sameAs m.0rfh2q4.
- Fasciclin_2 sameAs Q17145056.
- Fasciclin_2 wasDerivedFrom Fasciclin_2?oldid=611279342.
- Fasciclin_2 isPrimaryTopicOf Fasciclin_2.