Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Familial_adenomatous_polyposis> ?p ?o }
- Familial_adenomatous_polyposis abstract "Familial adenomatous polyposis (FAP) is an inherited condition in which numerous adenomatous polyps form mainly in the epithelium of the large intestine. While these polyps start out benign, malignant transformation into colon cancer occurs when they are left untreated. Three variants are known to exist, FAP and attenuated FAP (originally called “hereditary flat adenoma syndrome) are caused by APC gene defects on chromosome 5 while autosomal recessive FAP (or MYH-associated polyposis) is caused by defects in the MUTYH gene on chromosome 1. Of the three, FAP itself is the most severe and most common; although for all three, the resulting colonic polyps and cancers are confined to the colon wall and removal can greatly reduce the spread of cancer.The root cause of FAP is understood to be a genetic mutation—a flaw in the body's tumour suppressor genes that prevent development of tumours. The flaw allows numerous cells of the intestinal wall to develop into potentially cancerous polyps when they would usually reach the end of their life; inevitably one or more will eventually progress and give rise to cancer (7% risk by age 21, rising to 87% by age 45 and 93% by age 50). The flawed genes do not trigger cancer, but rather, they reduce the body's ability to protect against the risk of aged cells becoming cancerous. Even with the flawed gene, it may still take time before a cell actually does develop that is cancerous as a result, and the gene may in some cases still partially operate to control tumours, therefore cancer from FAP takes many years to develop and is almost always an adult-onset disease.The second form of FAP, known as attenuated familial adenomatous polyposis has the APC gene functional but slightly impaired. It is therefore somewhat able to operate as usual. Attenuated FAP still presents a high 70% lifetime risk of cancer (as estimated), but typically presents with far fewer polyps (typically 30) rather than the hundreds or thousands usually found in FAP, and arises at an age when FAP is usually no longer considered likely—typically between 40 and 70 years old (average 55) rather than the more usual 30's upward. Because it has far fewer polyps, options for management may be different.The third variant, autosomal recessive familial adenomatous polyposis or MYH-associated polyposis, is also milder and, as its name suggests, requires both parents to be 'carriers' to manifest the condition.In some cases FAP can manifest higher in the colon than usual (for example, the ascending colon, or proximal to the splenic flexure, or in the gastric or duodenal tracts) where they show no symptoms until cancer is present and greatly advanced. APC mutations have been linked to certain other cancers such as thyroid cancer. As the mutation causing FAP is genetic, it can be inherited hereditarily from either parent, and passed to children. A genetic blood test of the APC gene exists that can determine whether it is deficient, and therefore can predict the possibility of FAP. Individuals at risk (due to family links or genetic testing) are usually offered routine monitoring of the intestinal tract every 1 – 5 years for life, from early adulthood, to detect the slow-forming polyps and act if found, before they can pose a threat. International polyposis registries exists that track known cases of FAP or APC gene defects, for research and clinical purposes. Mutation of APC also occurs commonly in incident cases of colorectal carcinoma, emphasizing its importance in this form of cancer.".
- Familial_adenomatous_polyposis icd10 "C18,D12".
- Familial_adenomatous_polyposis icd9 "211.3".
- Familial_adenomatous_polyposis icdo "8220/0".
- Familial_adenomatous_polyposis meshId "D011125".
- Familial_adenomatous_polyposis omim "175100".
- Familial_adenomatous_polyposis thumbnail FAP.jpg?width=300.
- Familial_adenomatous_polyposis wikiPageExternalLink NBK1345.
- Familial_adenomatous_polyposis wikiPageExternalLink 175377-overview.
- Familial_adenomatous_polyposis wikiPageExternalLink condition=familialadenomatouspolyposis.
- Familial_adenomatous_polyposis wikiPageExternalLink healthprofessional.
- Familial_adenomatous_polyposis wikiPageExternalLink attenuated-familial-adenomatous-polyposis.
- Familial_adenomatous_polyposis wikiPageExternalLink familial-adenomatous-polyposis.
- Familial_adenomatous_polyposis wikiPageExternalLink topic567.htm.
- Familial_adenomatous_polyposis wikiPageExternalLink www.fapgene.com.
- Familial_adenomatous_polyposis wikiPageExternalLink br.fcgi?book=gene&part=fap.
- Familial_adenomatous_polyposis wikiPageExternalLink www.polyposisregistry.org.uk.
- Familial_adenomatous_polyposis wikiPageExternalLink index.htm.
- Familial_adenomatous_polyposis wikiPageID "1106793".
- Familial_adenomatous_polyposis wikiPageLength "37078".
- Familial_adenomatous_polyposis wikiPageOutDegree "124".
- Familial_adenomatous_polyposis wikiPageRevisionID "706723900".
- Familial_adenomatous_polyposis wikiPageWikiLink Adenine.
- Familial_adenomatous_polyposis wikiPageWikiLink Adenoma.
- Familial_adenomatous_polyposis wikiPageWikiLink Adenomatous_polyposis_coli.
- Familial_adenomatous_polyposis wikiPageWikiLink Allele.
- Familial_adenomatous_polyposis wikiPageWikiLink Anemia.
- Familial_adenomatous_polyposis wikiPageWikiLink Ascending_colon.
- Familial_adenomatous_polyposis wikiPageWikiLink Attenuation.
- Familial_adenomatous_polyposis wikiPageWikiLink Base_excision_repair.
- Familial_adenomatous_polyposis wikiPageWikiLink Benignity.
- Familial_adenomatous_polyposis wikiPageWikiLink Beta-catenin.
- Familial_adenomatous_polyposis wikiPageWikiLink Blood_test.
- Familial_adenomatous_polyposis wikiPageWikiLink Cancer.
- Familial_adenomatous_polyposis wikiPageWikiLink Carcinogenesis.
- Familial_adenomatous_polyposis wikiPageWikiLink Category:Benign_neoplasms.
- Familial_adenomatous_polyposis wikiPageWikiLink Category:Gastrointestinal_cancer.
- Familial_adenomatous_polyposis wikiPageWikiLink Category:Hereditary_cancers.
- Familial_adenomatous_polyposis wikiPageWikiLink Cell_nucleus.
- Familial_adenomatous_polyposis wikiPageWikiLink Colectomy.
- Familial_adenomatous_polyposis wikiPageWikiLink Colonoscopy.
- Familial_adenomatous_polyposis wikiPageWikiLink Colorectal_cancer.
- Familial_adenomatous_polyposis wikiPageWikiLink Colorectal_polyp.
- Familial_adenomatous_polyposis wikiPageWikiLink Conditional_mutants.
- Familial_adenomatous_polyposis wikiPageWikiLink Cytosine.
- Familial_adenomatous_polyposis wikiPageWikiLink Cytoskeleton.
- Familial_adenomatous_polyposis wikiPageWikiLink DNA.
- Familial_adenomatous_polyposis wikiPageWikiLink DNA_repair.
- Familial_adenomatous_polyposis wikiPageWikiLink Dominance_(genetics).
- Familial_adenomatous_polyposis wikiPageWikiLink Duodenum.
- Familial_adenomatous_polyposis wikiPageWikiLink EMedicine.
- Familial_adenomatous_polyposis wikiPageWikiLink Epithelium.
- Familial_adenomatous_polyposis wikiPageWikiLink Esophagogastroduodenoscopy.
- Familial_adenomatous_polyposis wikiPageWikiLink Fibroma.
- Familial_adenomatous_polyposis wikiPageWikiLink Gardners_syndrome.
- Familial_adenomatous_polyposis wikiPageWikiLink Gastrointestinal_tract.
- Familial_adenomatous_polyposis wikiPageWikiLink Genetic_counseling.
- Familial_adenomatous_polyposis wikiPageWikiLink Genetic_testing.
- Familial_adenomatous_polyposis wikiPageWikiLink Genotype.
- Familial_adenomatous_polyposis wikiPageWikiLink Germline_mosaicism.
- Familial_adenomatous_polyposis wikiPageWikiLink Guanine.
- Familial_adenomatous_polyposis wikiPageWikiLink Heredity.
- Familial_adenomatous_polyposis wikiPageWikiLink Histology.
- Familial_adenomatous_polyposis wikiPageWikiLink Histopathology.
- Familial_adenomatous_polyposis wikiPageWikiLink Ileo-anal_pouch.
- Familial_adenomatous_polyposis wikiPageWikiLink Ileorectal_anastomosis.
- Familial_adenomatous_polyposis wikiPageWikiLink Ileostomy.
- Familial_adenomatous_polyposis wikiPageWikiLink In_patient.
- Familial_adenomatous_polyposis wikiPageWikiLink Knudson_hypothesis.
- Familial_adenomatous_polyposis wikiPageWikiLink Large_intestine.
- Familial_adenomatous_polyposis wikiPageWikiLink Liver.
- Familial_adenomatous_polyposis wikiPageWikiLink Liver_function_tests.
- Familial_adenomatous_polyposis wikiPageWikiLink Lower_gastrointestinal_series.
- Familial_adenomatous_polyposis wikiPageWikiLink MUTYH.
- Familial_adenomatous_polyposis wikiPageWikiLink MYH_glycosylase.
- Familial_adenomatous_polyposis wikiPageWikiLink Malignant_transformation.
- Familial_adenomatous_polyposis wikiPageWikiLink Medical_ultrasound.
- Familial_adenomatous_polyposis wikiPageWikiLink Metastasis.
- Familial_adenomatous_polyposis wikiPageWikiLink Mosaic_(genetics).
- Familial_adenomatous_polyposis wikiPageWikiLink Mouse_model_of_colorectal_and_intestinal_cancer.
- Familial_adenomatous_polyposis wikiPageWikiLink Mutation.
- Familial_adenomatous_polyposis wikiPageWikiLink National_Institutes_of_Health.
- Familial_adenomatous_polyposis wikiPageWikiLink Nonsteroidal_anti-inflammatory_drug.
- Familial_adenomatous_polyposis wikiPageWikiLink Osteoma.
- Familial_adenomatous_polyposis wikiPageWikiLink Out_patient.
- Familial_adenomatous_polyposis wikiPageWikiLink Oxygen.
- Familial_adenomatous_polyposis wikiPageWikiLink P53.
- Familial_adenomatous_polyposis wikiPageWikiLink Penetrance.
- Familial_adenomatous_polyposis wikiPageWikiLink Polyp.
- Familial_adenomatous_polyposis wikiPageWikiLink Polyp_(medicine).
- Familial_adenomatous_polyposis wikiPageWikiLink Polypectomy.
- Familial_adenomatous_polyposis wikiPageWikiLink Polyposis_registries.
- Familial_adenomatous_polyposis wikiPageWikiLink Prenatal_diagnosis.
- Familial_adenomatous_polyposis wikiPageWikiLink Preventive_healthcare.
- Familial_adenomatous_polyposis wikiPageWikiLink Proband.
- Familial_adenomatous_polyposis wikiPageWikiLink Rectum.
- Familial_adenomatous_polyposis wikiPageWikiLink Retina.
- Familial_adenomatous_polyposis wikiPageWikiLink Sebaceous_cyst.
- Familial_adenomatous_polyposis wikiPageWikiLink Sigmoid_colon.
- Familial_adenomatous_polyposis wikiPageWikiLink Sigmoidoscopy.