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- FXYD_family abstract "The FXYD protein family is a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the amino acid sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator.It contains at least seven members in mammals. Two other family members that are not obvious orthologs of any identified mammalian FXYD protein exist in zebrafish. All these proteins share a signature sequence of six conserved amino acids comprising the FXYD motif in the NH2-terminus, and two glycines andone serine residue in the transmembrane domain. FXYD proteins are widely distributed in mammalian tissues with prominent expression in tissues that perform fluid and solute transport or that are electrically excitable.Initial functional characterization suggested that FXYD proteins act as channels or as modulators of ion channels. However, studies have revealed that most FXYD proteins have another specific function and act as tissue-specificregulatory subunits of the Na,K-ATPase. Each of these auxiliary subunits produces a distinct functional effect on the transport characteristics of the Na,K-ATPase that is adjusted to the specific functional demands of the tissue in which the FXYD protein is expressed. FXYD proteins appear to preferentially associate with Na,K-ATPase alpha1-beta isozymes, and affect their function in a way that render them operationally complementary or supplementary to coexisting isozymes.".
- FXYD_family symbol "ATP1G1_PLM_MAT8".
- FXYD_family thumbnail PDB_2jo1_EBI.png?width=300.
- FXYD_family wikiPageID "24555400".
- FXYD_family wikiPageLength "2856".
- FXYD_family wikiPageOutDegree "21".
- FXYD_family wikiPageRevisionID "591381992".
- FXYD_family wikiPageWikiLink Category:Protein_domains.
- FXYD_family wikiPageWikiLink Category:Protein_families.
- FXYD_family wikiPageWikiLink Category:Single-pass_transmembrane_proteins.
- FXYD_family wikiPageWikiLink Channel-inducing_factor_4.
- FXYD_family wikiPageWikiLink FXYD1.
- FXYD_family wikiPageWikiLink FXYD2.
- FXYD_family wikiPageWikiLink FXYD3.
- FXYD_family wikiPageWikiLink FXYD5.
- FXYD_family wikiPageWikiLink FXYD6.
- FXYD_family wikiPageWikiLink FXYD7.
- FXYD_family wikiPageWikiLink FXYD8.
- FXYD_family wikiPageWikiLink Glycine.
- FXYD_family wikiPageWikiLink Homology_(biology).
- FXYD_family wikiPageWikiLink Ion_channel.
- FXYD_family wikiPageWikiLink Isozyme.
- FXYD_family wikiPageWikiLink KCT1.
- FXYD_family wikiPageWikiLink K+-ATPase.
- FXYD_family wikiPageWikiLink Peptide_sequence.
- FXYD_family wikiPageWikiLink Serine.
- FXYD_family wikiPageWikiLink Transmembrane_domain.
- FXYD_family wikiPageWikiLink Transmembrane_protein.
- FXYD_family wikiPageWikiLinkText "FXYD family".
- FXYD_family wikiPageWikiLinkText "phospholemman".
- FXYD_family caption "Structure of Na,K-ATPase regulatory protein FXYD1.".
- FXYD_family interpro "IPR000272".
- FXYD_family name "ATP1G1/PLM/MAT8 family".
- FXYD_family opmFamily "70".
- FXYD_family opmProtein "2".
- FXYD_family pfam "PF02038".
- FXYD_family prosite "PS01310".
- FXYD_family symbol "ATP1G1_PLM_MAT8".
- FXYD_family tcdb "1".
- FXYD_family wikiPageUsesTemplate Template:Infobox_protein_family.
- FXYD_family wikiPageUsesTemplate Template:InterPro_content.
- FXYD_family wikiPageUsesTemplate Template:Reflist.
- FXYD_family subject Category:Protein_domains.
- FXYD_family subject Category:Protein_families.
- FXYD_family subject Category:Single-pass_transmembrane_proteins.
- FXYD_family hypernym Family.
- FXYD_family type Biomolecule.
- FXYD_family type Protein.
- FXYD_family type Chemical.
- FXYD_family type Domain.
- FXYD_family type Thing.
- FXYD_family type Q206229.
- FXYD_family type Q8054.
- FXYD_family comment "The FXYD protein family is a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the amino acid sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator.It contains at least seven members in mammals. Two other family members that are not obvious orthologs of any identified mammalian FXYD protein exist in zebrafish.".
- FXYD_family label "FXYD family".
- FXYD_family sameAs Q5427396.
- FXYD_family sameAs m.080662h.
- FXYD_family sameAs Q5427396.
- FXYD_family wasDerivedFrom FXYD_family?oldid=591381992.
- FXYD_family depiction PDB_2jo1_EBI.png.
- FXYD_family isPrimaryTopicOf FXYD_family.