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- F13B abstract "Coagulation factor XIII B chain is a protein that in humans is encoded by the F13B gene.This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.".
- F13B entrezgene "2165".
- F13B wikiPageID "14177894".
- F13B wikiPageLength "8925".
- F13B wikiPageOutDegree "4".
- F13B wikiPageRevisionID "661023176".
- F13B wikiPageWikiLink Coagulation_factor_XIII,_A1_polypeptide.
- F13B wikiPageWikiLink Gene.
- F13B wikiPageWikiLink Protein.
- F13B wikiPageWikiLink Protein–protein_interaction.
- F13B wikiPageWikiLinkText "B subunit".
- F13B wikiPageWikiLinkText "F13B".
- F13B requireManualInspection "no".
- F13B summaryText "This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.".
- F13B updateCitations "yes".
- F13B updatePage "yes".
- F13B updateProteinBox "yes".
- F13B updateSummary "yes".
- F13B wikiPageUsesTemplate Template:Cite_journal.
- F13B wikiPageUsesTemplate Template:Gene-1-stub.
- F13B wikiPageUsesTemplate Template:PBB.
- F13B wikiPageUsesTemplate Template:PBB_Controls.
- F13B wikiPageUsesTemplate Template:PBB_Further_reading.
- F13B wikiPageUsesTemplate Template:PBB_Summary.
- F13B wikiPageUsesTemplate Template:Refbegin.
- F13B wikiPageUsesTemplate Template:Refend.
- F13B wikiPageUsesTemplate Template:Reflist.
- F13B hypernym Protein.
- F13B type Biomolecule.
- F13B type Protein.
- F13B type Thing.
- F13B type Q206229.
- F13B type Q8054.
- F13B comment "Coagulation factor XIII B chain is a protein that in humans is encoded by the F13B gene.This gene encodes coagulation factor XIII B subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as a plasma carrier molecules.".
- F13B label "F13B".
- F13B sameAs Q17927047.
- F13B sameAs Untereinheit_B_des_Fibrinstabilisierenden_Faktors.
- F13B sameAs m.03cx038.
- F13B sameAs Q17927047.
- F13B wasDerivedFrom F13B?oldid=661023176.
- F13B isPrimaryTopicOf F13B.