Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/F-15063> ?p ?o }
Showing triples 1 to 64 of
64
with 100 triples per page.
- F-15063 abstract "F-15,063 is an orally active potential antipsychotic, and an antagonist at the D2/D3 receptors, partial agonist at the D4 receptor, and agonist at the 5-HT1A receptors. It has greater efficacy at the 5-HT1A receptors than other antipsychotics, such as clozapine, aripiprazole, and ziprasidone. This greater efficacy may lead to enhanced antipsychotic properties, as antipsychotics that lack 5-HT1A affinity are associated with increased risk of extrapyramidal symptoms, and lack of activity against the negative symptoms of schizophrenia.As expression of immediate-early gene (IEG) in certain brain regions may represent markers of anti-psychotic activity, expression of immediate-early gene mRNA in the prefrontal cortex and striatum was measured. Treatment with F-15,063 resulted in induction of c-fos and fosB mRNA expression in the prefrontal cortex. In the striatum, F-15,063 treatment resulted in induction of all IEGs studied (c-fos, fosB, zif268, c-jun, junB, nor1, nur77, arc).F-15,063 was tested in several animal models that predict antipsychotic activity to help determine the behavioral profile. Administration of F-15,063 blocked amphetamine and ketamine induced hyperlocomotion, but did not affect baseline, spontaneous locomotor activity. In addition, F-15,063 did not produce catalepsy, a side effect of other antipsychotics, such as haloperidol. This inhibition of catalepsy is 5-HT1A receptor mediated, as pretreatment with the 5-HT1A antagonist WAY-100635 reinstated catalepsy. The level of catalepsy did not increase with chronic dosing, and there was no evidence for serotonin syndrome at clinically relevant doses.Plasma levels of F-15,063 decreased seven-fold 4 hours after oral administration, and 25-fold after 8 hours. Despite this, there was still a high (65%) level of central D2 occupancy at 4 hours, and it retained its full antipsychotic potential at this time point. Even after 8 hours, F-15,063 still demonstrated some central D2 occupancy, and retained some antipsychotic activity.".
- F-15063 iupacName "(N-[(2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl]-3-(cyclopent-1-enyl)-benzylamine)".
- F-15063 thumbnail F_15_063.svg?width=300.
- F-15063 wikiPageID "34178462".
- F-15063 wikiPageLength "4743".
- F-15063 wikiPageOutDegree "31".
- F-15063 wikiPageRevisionID "670415406".
- F-15063 wikiPageWikiLink 5-HT1A_receptor.
- F-15063 wikiPageWikiLink Amphetamine.
- F-15063 wikiPageWikiLink Antagonist.
- F-15063 wikiPageWikiLink Antipsychotic.
- F-15063 wikiPageWikiLink Arc_(protein).
- F-15063 wikiPageWikiLink Aripiprazole.
- F-15063 wikiPageWikiLink C-Fos.
- F-15063 wikiPageWikiLink C-jun.
- F-15063 wikiPageWikiLink Catalepsy.
- F-15063 wikiPageWikiLink Category:Antipsychotics.
- F-15063 wikiPageWikiLink Clozapine.
- F-15063 wikiPageWikiLink Dopamine_receptor_D2.
- F-15063 wikiPageWikiLink Dopamine_receptor_D3.
- F-15063 wikiPageWikiLink Dopamine_receptor_D4.
- F-15063 wikiPageWikiLink EGR1.
- F-15063 wikiPageWikiLink Extrapyramidal_symptoms.
- F-15063 wikiPageWikiLink FOSB.
- F-15063 wikiPageWikiLink Haloperidol.
- F-15063 wikiPageWikiLink Immediate_early_gene.
- F-15063 wikiPageWikiLink JUNB.
- F-15063 wikiPageWikiLink Ketamine.
- F-15063 wikiPageWikiLink Messenger_RNA.
- F-15063 wikiPageWikiLink Nerve_growth_factor_IB.
- F-15063 wikiPageWikiLink Neuron-derived_orphan_receptor_1.
- F-15063 wikiPageWikiLink Partial_agonist.
- F-15063 wikiPageWikiLink Prefrontal_cortex.
- F-15063 wikiPageWikiLink Schizophrenia.
- F-15063 wikiPageWikiLink Serotonin_syndrome.
- F-15063 wikiPageWikiLink Striatum.
- F-15063 wikiPageWikiLink WAY-100,635.
- F-15063 wikiPageWikiLink Ziprasidone.
- F-15063 wikiPageWikiLinkText "F-15063".
- F-15063 imagefile "F 15 063.svg".
- F-15063 othernames "F-15,063".
- F-15063 wikiPageUsesTemplate Template:Antipsychotics.
- F-15063 wikiPageUsesTemplate Template:Chembox.
- F-15063 wikiPageUsesTemplate Template:Chembox_Hazards.
- F-15063 wikiPageUsesTemplate Template:Chembox_Identifiers.
- F-15063 wikiPageUsesTemplate Template:Chembox_Properties.
- F-15063 wikiPageUsesTemplate Template:Dopaminergics.
- F-15063 wikiPageUsesTemplate Template:Reflist.
- F-15063 wikiPageUsesTemplate Template:Serotonergics.
- F-15063 subject Category:Antipsychotics.
- F-15063 type ChemicalCompound.
- F-15063 type ChemicalSubstance.
- F-15063 type ChemicalObject.
- F-15063 type Thing.
- F-15063 type Q11173.
- F-15063 comment "F-15,063 is an orally active potential antipsychotic, and an antagonist at the D2/D3 receptors, partial agonist at the D4 receptor, and agonist at the 5-HT1A receptors. It has greater efficacy at the 5-HT1A receptors than other antipsychotics, such as clozapine, aripiprazole, and ziprasidone.".
- F-15063 label "F-15063".
- F-15063 sameAs Q5423586.
- F-15063 sameAs اف-۱۵٬۰۶۳.
- F-15063 sameAs m.0hr8f7d.
- F-15063 sameAs Q5423586.
- F-15063 wasDerivedFrom F-15063?oldid=670415406.
- F-15063 depiction F_15_063.svg.
- F-15063 isPrimaryTopicOf F-15063.