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- Expansion_microscopy abstract "Expansion Microscopy (ExM) is a sample preparation tool for biological samples that allows investigators to identify small structures by expanding them using a polymer system. The premise is to introduce a polymer network into cellular or tissue samples, and then physically expand that polymer network using chemical reactions to increase the size of the biological structures. Among other benefits, this allows those small structures to be imaged with a wider range of microscopy techniques. It was first proposed in a 2015 article by Fei Chen, Paul W. Tillberg, and Edward Boyden.Traditional light microscopy has limits of resolution that prevent it from reliably distinguishing small structures that are important to biological function, and must instead be imaged by a lower-resolution technique, such as electron microscopy. For example, synaptic vesicles are 40-50 nanometers in diameter, which is below the commonly quoted resolution limit of 200 nanometers for light microscopy. Expansion microscopy solves this problem by expanding the underlying tissue sample. One key advantage of samples prepared using expansion microscopy and light microscopy over conventional electron microscopy is that it also allows for investigators to stain for and visualize particular molecules in the sample, such as proteins, to identify their density and distribution in relation to the biological structures of interest.".
- Expansion_microscopy wikiPageID "48309708".
- Expansion_microscopy wikiPageLength "2361".
- Expansion_microscopy wikiPageOutDegree "8".
- Expansion_microscopy wikiPageRevisionID "692743140".
- Expansion_microscopy wikiPageWikiLink Category:Microscopy.
- Expansion_microscopy wikiPageWikiLink Category:Polymers.
- Expansion_microscopy wikiPageWikiLink Edward_Boyden.
- Expansion_microscopy wikiPageWikiLink Electron_microscope.
- Expansion_microscopy wikiPageWikiLink Microscopy.
- Expansion_microscopy wikiPageWikiLink Polymer.
- Expansion_microscopy wikiPageWikiLink Protein.
- Expansion_microscopy wikiPageWikiLink Synaptic_vesicle.
- Expansion_microscopy wikiPageUsesTemplate Template:Reflist.
- Expansion_microscopy subject Category:Microscopy.
- Expansion_microscopy subject Category:Polymers.
- Expansion_microscopy hypernym Tool.
- Expansion_microscopy type Software.
- Expansion_microscopy comment "Expansion Microscopy (ExM) is a sample preparation tool for biological samples that allows investigators to identify small structures by expanding them using a polymer system. The premise is to introduce a polymer network into cellular or tissue samples, and then physically expand that polymer network using chemical reactions to increase the size of the biological structures. Among other benefits, this allows those small structures to be imaged with a wider range of microscopy techniques.".
- Expansion_microscopy label "Expansion microscopy".
- Expansion_microscopy wasDerivedFrom Expansion_microscopy?oldid=692743140.
- Expansion_microscopy isPrimaryTopicOf Expansion_microscopy.