Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Examorelin> ?p ?o }
- Examorelin abstract "Examorelin (INN) (developmental code names EP-23905, MF-6003), also known as hexarelin, is a potent, synthetic, peptidic, orally-active, centrally-penetrant, and highly selective agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and a growth hormone secretagogue which was developed by Mediolanum Farmaceutici. It is a hexapeptide with the amino acid sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 which was derived from GHRP-6 (which, in turn, is an analogue of ghrelin).Examorelin substantially and dose-dependently increases plasma levels of growth hormone (GH) in animals and humans. In addition, similarly to pralmorelin (GHRP-2) and GHRP-6, it slightly and dose-dependently stimulates the release of prolactin, adrenocorticotropic hormone (ACTH), and cortisol in humans. There are conflicting reports on the ability of examorelin to elevate insulin-like growth factor 1 (IGF-1) and insulin-like growth factor-binding protein 1 (IGFBP-1) levels in humans, with some studies finding no increase and others finding a slight yet statistically significant increase. Examorelin does not affect plasma levels of glucose, luteinizing hormone (LH), follicle-stimulating hormone (FSH), or thyroid-stimulating hormone (TSH) in humans.Examorelin releases more GH than does growth hormone-releasing hormone (GHRH) in humans, and produces synergistic effects on GH release in combination with GHRH, resulting in \"massive\" increases in plasma GH levels even with only low doses of examorelin. Pre-administration of GH blunts the GH-releasing effect of examorelin, while, in contrast, fully abolishing the effect of GHRH. Pre-treatment with IGF-1 also blunts the GH-elevating effect of examorelin. Testosterone, testosterone enanthate, and ethinyl estradiol, though not oxandrolone, have been found to significantly potentiate the GH-releasing effects of examorelin in humans. In accordance, likely due to increases in sex steroid levels, puberty has also been found to significantly augment the GH-elevating actions of examorelin in humans.A partial and reversible tolerance to the GH-releasing effects of examorelin occurs in humans with long-term administration (50–75% decrease in efficacy over the course of weeks to months).Examorelin reached phase II clinical trials for the treatment of growth hormone deficiency and congestive heart failure but did not complete development and was never marketed.".
- Examorelin atcPrefix "None".
- Examorelin casNumber "140703-51-1".
- Examorelin iupacName "(2S)-6-amino-2-(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide".
- Examorelin pubchem "6918297".
- Examorelin thumbnail Hexarelin_structure.png?width=300.
- Examorelin wikiPageID "46963951".
- Examorelin wikiPageLength "18055".
- Examorelin wikiPageOutDegree "57".
- Examorelin wikiPageRevisionID "695938269".
- Examorelin wikiPageWikiLink Adrenocorticotropic_hormone.
- Examorelin wikiPageWikiLink Agonist.
- Examorelin wikiPageWikiLink Anamorelin.
- Examorelin wikiPageWikiLink Blood_plasma.
- Examorelin wikiPageWikiLink Capromorelin.
- Examorelin wikiPageWikiLink Category:Ghrelin_receptor_agonists.
- Examorelin wikiPageWikiLink Category:Growth_hormone_secretagogues.
- Examorelin wikiPageWikiLink Category:Hormonal_agents.
- Examorelin wikiPageWikiLink Category:Peptides.
- Examorelin wikiPageWikiLink Central_nervous_system.
- Examorelin wikiPageWikiLink Clinical_trial.
- Examorelin wikiPageWikiLink Cortisol.
- Examorelin wikiPageWikiLink Ethinyl_estradiol.
- Examorelin wikiPageWikiLink Follicle-stimulating_hormone.
- Examorelin wikiPageWikiLink GHRP-6.
- Examorelin wikiPageWikiLink Ghrelin.
- Examorelin wikiPageWikiLink Glucose.
- Examorelin wikiPageWikiLink Growth_hormone.
- Examorelin wikiPageWikiLink Growth_hormone_deficiency.
- Examorelin wikiPageWikiLink Growth_hormone_secretagogue.
- Examorelin wikiPageWikiLink Growth_hormone_secretagogue_receptor.
- Examorelin wikiPageWikiLink Growth_hormone–releasing_hormone.
- Examorelin wikiPageWikiLink Heart_failure.
- Examorelin wikiPageWikiLink IGFBP1.
- Examorelin wikiPageWikiLink Ibutamoren.
- Examorelin wikiPageWikiLink Insufflation_(medicine).
- Examorelin wikiPageWikiLink Insulin-like_growth_factor_1.
- Examorelin wikiPageWikiLink International_nonproprietary_name.
- Examorelin wikiPageWikiLink Intravenous_therapy.
- Examorelin wikiPageWikiLink Ipamorelin.
- Examorelin wikiPageWikiLink Luteinizing_hormone.
- Examorelin wikiPageWikiLink Macimorelin.
- Examorelin wikiPageWikiLink Mediolanum_Farmaceutici.
- Examorelin wikiPageWikiLink Oral_administration.
- Examorelin wikiPageWikiLink Organic_compound.
- Examorelin wikiPageWikiLink Oxandrolone.
- Examorelin wikiPageWikiLink Peptide.
- Examorelin wikiPageWikiLink Peptide_sequence.
- Examorelin wikiPageWikiLink Phases_of_clinical_research.
- Examorelin wikiPageWikiLink Potency_(pharmacology).
- Examorelin wikiPageWikiLink Pralmorelin.
- Examorelin wikiPageWikiLink Prolactin.
- Examorelin wikiPageWikiLink Puberty.
- Examorelin wikiPageWikiLink Relamorelin.
- Examorelin wikiPageWikiLink SM-130,686.
- Examorelin wikiPageWikiLink Sex_steroid.
- Examorelin wikiPageWikiLink Structural_analog.
- Examorelin wikiPageWikiLink Subcutaneous_injection.
- Examorelin wikiPageWikiLink Tabimorelin.
- Examorelin wikiPageWikiLink Testosterone.
- Examorelin wikiPageWikiLink Thyroid-stimulating_hormone.
- Examorelin wikiPageWikiLink nowiki%3E.
- Examorelin wikiPageWikiLinkText "Examorelin (hexarelin)".
- Examorelin wikiPageWikiLinkText "Examorelin".
- Examorelin wikiPageWikiLinkText "examorelin".
- Examorelin atcPrefix "None".
- Examorelin c "47".
- Examorelin casNumber "140703".
- Examorelin chembl "108335".
- Examorelin chemspiderid "5293503".
- Examorelin eliminationHalfLife "3300.0".
- Examorelin h "58".
- Examorelin inchi "1".
- Examorelin inchikey "RVWNMGKSNGWLOL-GIIHNPQRBK".
- Examorelin iupacName "-6".
- Examorelin iupharLigand "1100".
- Examorelin molecularWeight "887.04022".
- Examorelin n "12".
- Examorelin o "6".
- Examorelin pubchem "6918297".
- Examorelin routesOfAdministration Insufflation_(medicine).
- Examorelin routesOfAdministration Intranasal.
- Examorelin routesOfAdministration Intravenous.
- Examorelin routesOfAdministration Intravenous_therapy.
- Examorelin routesOfAdministration Oral_administration.
- Examorelin routesOfAdministration Subcutaneous_injection.
- Examorelin smiles "CC1=CC[C@H]NC[C@H]N".
- Examorelin stdinchi "1".
- Examorelin stdinchikey "RVWNMGKSNGWLOL-GIIHNPQRSA-N".
- Examorelin synonyms "(L)-Histidyl-2-methyl-(D)-tryptophyl-(L)-alanyl-(L)-tryptophyl-(D)-phenylalanyl-(L)-lysinamide".
- Examorelin width "300".
- Examorelin wikiPageUsesTemplate Template:Drugbox.
- Examorelin wikiPageUsesTemplate Template:Neuropeptidergics.
- Examorelin wikiPageUsesTemplate Template:Reflist.
- Examorelin subject Category:Ghrelin_receptor_agonists.
- Examorelin subject Category:Growth_hormone_secretagogues.
- Examorelin subject Category:Hormonal_agents.
- Examorelin subject Category:Peptides.
- Examorelin type ChemicalSubstance.
- Examorelin type Drug.