Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Ethyl_loflazepate> ?p ?o }
- Ethyl_loflazepate abstract "Ethyl loflazepate (marketed under the brand names Meilax, Ronlax and Victan) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. In animal studies it was found to have low toxicity, although in rats evidence of pulmonary phospholipidosis occurred with pulmonary foam cells developing with long-term use of very high doses. Its elimination half-life is 51–103 hours. Its mechanism of action is similar to other benzodiazepines. Ethyl loflazepate also produces an active metabolite which is stronger than the parent compound. Ethyl loflazepate was designed to be a prodrug for descarboxyloflazepate, its active metabolite. It is the active metabolite which is responsible for most of the pharmacological effects rather than ethyl loflazepate. The main metabolites of ethyl loflazepate are descarbethoxyloflazepate, loflazepate and 3-hydroxydescarbethoxyloflazepate. Accumulation of the active metabolites of ethyl loflazepate are not affected by those with renal failure or impairment. The symptoms of an overdose of ethyl loflazepate include sleepiness, agitation and ataxia. Hypotonia may also occur in severe cases. These symptoms occur much more frequently and severely in children. Death from therapeutic maintenance doses of ethyl loflazepate taken for 2 – 3 weeks has been reported in 3 elderly patients. The cause of death was asphyxia due to benzodiazepine toxicity. High doses of the antidepressant fluvoxamine may potentiate the adverse effects of ethyl loflazepate.Ethyl loflazeplate is commercialized in Mexico, under the trade name Victan. It is officially approved for the following conditions:AnxietyPost-trauma anxietyAnxiety associated with severe neuropathic pain.Generalized anxiety disorder (GAD)Anxiety \"crisis\"Delirium tremens↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑ ↑".
- Ethyl_loflazepate atcPrefix "N05".
- Ethyl_loflazepate atcSuffix "BA18".
- Ethyl_loflazepate casNumber "29177-84-2".
- Ethyl_loflazepate drugbank "DB01545".
- Ethyl_loflazepate fdaUniiCode "VJB5FW9W9J".
- Ethyl_loflazepate iupacName "ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate".
- Ethyl_loflazepate pubchem "3299".
- Ethyl_loflazepate thumbnail Ethyl_loflazepate.svg?width=300.
- Ethyl_loflazepate wikiPageExternalLink 1mlph.pdf.
- Ethyl_loflazepate wikiPageID "4133969".
- Ethyl_loflazepate wikiPageLength "9238".
- Ethyl_loflazepate wikiPageOutDegree "32".
- Ethyl_loflazepate wikiPageRevisionID "705854548".
- Ethyl_loflazepate wikiPageWikiLink Active_metabolite.
- Ethyl_loflazepate wikiPageWikiLink Anticonvulsant.
- Ethyl_loflazepate wikiPageWikiLink Anxiety.
- Ethyl_loflazepate wikiPageWikiLink Anxiolytic.
- Ethyl_loflazepate wikiPageWikiLink Asphyxia.
- Ethyl_loflazepate wikiPageWikiLink Ataxia.
- Ethyl_loflazepate wikiPageWikiLink Benzodiazepine.
- Ethyl_loflazepate wikiPageWikiLink Category:Benzodiazepines.
- Ethyl_loflazepate wikiPageWikiLink Category:Chloroarenes.
- Ethyl_loflazepate wikiPageWikiLink Category:Ethyl_esters.
- Ethyl_loflazepate wikiPageWikiLink Category:GABAA_receptor_positive_allosteric_modulators.
- Ethyl_loflazepate wikiPageWikiLink Category:Hypnotics.
- Ethyl_loflazepate wikiPageWikiLink Category:Lactams.
- Ethyl_loflazepate wikiPageWikiLink Category:Organofluorides.
- Ethyl_loflazepate wikiPageWikiLink Delirium_tremens.
- Ethyl_loflazepate wikiPageWikiLink Drug_overdose.
- Ethyl_loflazepate wikiPageWikiLink Generalized_anxiety_disorder.
- Ethyl_loflazepate wikiPageWikiLink Hypotonia.
- Ethyl_loflazepate wikiPageWikiLink Kidney.
- Ethyl_loflazepate wikiPageWikiLink Liver.
- Ethyl_loflazepate wikiPageWikiLink Mexico.
- Ethyl_loflazepate wikiPageWikiLink Muscle_relaxant.
- Ethyl_loflazepate wikiPageWikiLink N-Desalkylflurazepam.
- Ethyl_loflazepate wikiPageWikiLink Panic_attack.
- Ethyl_loflazepate wikiPageWikiLink Posttraumatic_stress_disorder.
- Ethyl_loflazepate wikiPageWikiLink Prodrug.
- Ethyl_loflazepate wikiPageWikiLink Psychomotor_agitation.
- Ethyl_loflazepate wikiPageWikiLink Renal_failure.
- Ethyl_loflazepate wikiPageWikiLink Sedative.
- Ethyl_loflazepate wikiPageWikiLink Somnolence.
- Ethyl_loflazepate wikiPageWikiLinkText "Ethyl loflazepate".
- Ethyl_loflazepate wikiPageWikiLinkText "ethyl loflazepate".
- Ethyl_loflazepate atcPrefix "N05".
- Ethyl_loflazepate atcSuffix "BA18".
- Ethyl_loflazepate bioavailability "?".
- Ethyl_loflazepate c "18".
- Ethyl_loflazepate casNumber "29177".
- Ethyl_loflazepate chembl "1213460".
- Ethyl_loflazepate chemspiderid "3183".
- Ethyl_loflazepate cl "1".
- Ethyl_loflazepate drugbank "DB01545".
- Ethyl_loflazepate eliminationHalfLife "-370800.0".
- Ethyl_loflazepate excretion Kidney.
- Ethyl_loflazepate f "1".
- Ethyl_loflazepate h "14".
- Ethyl_loflazepate image "EtLoflazepate3d.png".
- Ethyl_loflazepate iupacName "ethyl 7-chloro-5--2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate".
- Ethyl_loflazepate kegg "D01293".
- Ethyl_loflazepate legalDe "Anlage III".
- Ethyl_loflazepate legalUs "Schedule IV".
- Ethyl_loflazepate metabolism Liver.
- Ethyl_loflazepate molecularWeight "360.7".
- Ethyl_loflazepate n "2".
- Ethyl_loflazepate o "3".
- Ethyl_loflazepate pregnancyCategory "?".
- Ethyl_loflazepate pubchem "3299".
- Ethyl_loflazepate routesOfAdministration "Oral".
- Ethyl_loflazepate smiles "FC1=CC=CC=C1C2=NCC=O".
- Ethyl_loflazepate stdinchi "1".
- Ethyl_loflazepate stdinchikey "CUCHJCMWNFEYOM-UHFFFAOYSA-N".
- Ethyl_loflazepate tradename "Victan, Meilax, Ronlax".
- Ethyl_loflazepate unii "VJB5FW9W9J".
- Ethyl_loflazepate verifiedfields "changed".
- Ethyl_loflazepate verifiedrevid "461097130".
- Ethyl_loflazepate watchedfields "changed".
- Ethyl_loflazepate width "190".
- Ethyl_loflazepate width "222".
- Ethyl_loflazepate wikiPageUsesTemplate Template:Anxiolytics.
- Ethyl_loflazepate wikiPageUsesTemplate Template:Benzodiazepines.
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- Ethyl_loflazepate wikiPageUsesTemplate Template:Ebicite.
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- Ethyl_loflazepate wikiPageUsesTemplate Template:GABAAR_PAMs.
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- Ethyl_loflazepate subject Category:Benzodiazepines.
- Ethyl_loflazepate subject Category:Chloroarenes.
- Ethyl_loflazepate subject Category:Ethyl_esters.
- Ethyl_loflazepate subject Category:GABAA_receptor_positive_allosteric_modulators.
- Ethyl_loflazepate subject Category:Hypnotics.