Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Etanercept> ?p ?o }
- Etanercept abstract "Etanercept (trade name Enbrel) is a biopharmaceutical that treats autoimmune diseases by interfering with tumor necrosis factor (TNF; a soluble inflammatory cytokine) by acting as a TNF inhibitor. It has U.S. F.D.A. approval to treat rheumatoid arthritis, juvenile rheumatoid arthritis and psoriatic arthritis, plaque psoriasis and ankylosing spondylitis. TNF-alpha is the \"master regulator\" of the inflammatory (immune) response in many organ systems. Autoimmune diseases are caused by an overactive immune response. Etanercept has the potential to treat these diseases by inhibiting TNF-alpha.Etanercept is a fusion protein produced by recombinant DNA. It fuses the TNF receptor to the constant end of the IgG1 antibody. First, the developers isolated the DNA sequence that codes the human gene for soluble TNF receptor 2, which is a receptor that binds to tumor necrosis factor-alpha. Second, they isolated the DNA sequence that codes the human gene for the Fc end of immunoglobulin G1 (IgG1). Third, they linked the DNA for TNF receptor 2 to the DNA for IgG1 Fc. Finally, they expressed the linked DNA to produce a protein that links the protein for TNF receptor 2 to the protein for IgG1 Fc.The prototypic fusion protein was first synthesized and shown to be highly active and unusually stable as a modality for blockade of TNF in vivo in the early 1990s by Bruce A. Beutler, an academic researcher then at the University of Texas Southwestern Medical Center at Dallas, and his colleagues. These investigators also patented the protein, selling all rights to its use to Immunex, a biotechnology company that was acquired by Amgen in 2002.It is a large molecule, with a molecular weight of 150 kDa., that binds to TNFα and decreases its role in disorders involving excess inflammation in humans and other animals, including autoimmune diseases such as ankylosing spondylitis, juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and, potentially, in a variety of other disorders mediated by excess TNFα.".
- Etanercept atcPrefix "L04".
- Etanercept atcSuffix "AB01".
- Etanercept bioavailability "58.0".
- Etanercept casNumber "185243-69-0".
- Etanercept drugbank "DB00005".
- Etanercept fdaUniiCode "OP401G7OJC".
- Etanercept thumbnail Enbrel.jpg?width=300.
- Etanercept wikiPageExternalLink enbrel.pdf.
- Etanercept wikiPageExternalLink Altebrel.html.
- Etanercept wikiPageExternalLink www.enbrel.com.
- Etanercept wikiPageID "732438".
- Etanercept wikiPageLength "18136".
- Etanercept wikiPageOutDegree "64".
- Etanercept wikiPageRevisionID "704285254".
- Etanercept wikiPageWikiLink Adalimumab.
- Etanercept wikiPageWikiLink Amgen.
- Etanercept wikiPageWikiLink Ankylosing_spondylitis.
- Etanercept wikiPageWikiLink Atomic_mass_unit.
- Etanercept wikiPageWikiLink Australia.
- Etanercept wikiPageWikiLink Autoimmune_disease.
- Etanercept wikiPageWikiLink Biopharmaceutical.
- Etanercept wikiPageWikiLink Biosimilar.
- Etanercept wikiPageWikiLink Bruce_Beutler.
- Etanercept wikiPageWikiLink CD120.
- Etanercept wikiPageWikiLink Category:Amgen.
- Etanercept wikiPageWikiLink Category:Immunosuppressants.
- Etanercept wikiPageWikiLink Category:Recombinant_proteins.
- Etanercept wikiPageWikiLink Category:TNF_inhibitors.
- Etanercept wikiPageWikiLink Category:Wyeth.
- Etanercept wikiPageWikiLink Certolizumab_pegol.
- Etanercept wikiPageWikiLink Cytokine.
- Etanercept wikiPageWikiLink Decoy.
- Etanercept wikiPageWikiLink European_Union.
- Etanercept wikiPageWikiLink Fragment_crystallizable_region.
- Etanercept wikiPageWikiLink Fusion_protein.
- Etanercept wikiPageWikiLink Golimumab.
- Etanercept wikiPageWikiLink Granulomatosis_with_polyangiitis.
- Etanercept wikiPageWikiLink Immunoglobulin_G.
- Etanercept wikiPageWikiLink Inflammation.
- Etanercept wikiPageWikiLink Infliximab.
- Etanercept wikiPageWikiLink Juvenile_idiopathic_arthritis.
- Etanercept wikiPageWikiLink Lymphocyte.
- Etanercept wikiPageWikiLink Macrophage.
- Etanercept wikiPageWikiLink Monoclonal_antibody.
- Etanercept wikiPageWikiLink Mononuclear_phagocyte_system.
- Etanercept wikiPageWikiLink Pegsunercept.
- Etanercept wikiPageWikiLink Pfizer.
- Etanercept wikiPageWikiLink Protein_dimer.
- Etanercept wikiPageWikiLink Psoriasis.
- Etanercept wikiPageWikiLink Psoriatic_arthritis.
- Etanercept wikiPageWikiLink Receptor_(biochemistry).
- Etanercept wikiPageWikiLink Recombinant_DNA.
- Etanercept wikiPageWikiLink Rheumatoid_arthritis.
- Etanercept wikiPageWikiLink Sepsis.
- Etanercept wikiPageWikiLink TNF_inhibitor.
- Etanercept wikiPageWikiLink Takeda_Pharmaceutical_Company.
- Etanercept wikiPageWikiLink Tumor_necrosis_factor_alpha.
- Etanercept wikiPageWikiLink Tumor_necrosis_factors.
- Etanercept wikiPageWikiLink United_Kingdom.
- Etanercept wikiPageWikiLink United_States.
- Etanercept wikiPageWikiLink University_of_Texas_Southwestern_Medical_Center.
- Etanercept wikiPageWikiLink Vasculitis.
- Etanercept wikiPageWikiLink White_blood_cell.
- Etanercept wikiPageWikiLink Wyeth.
- Etanercept wikiPageWikiLinkText "Enbrel (Etanercept)".
- Etanercept wikiPageWikiLinkText "Etanercept".
- Etanercept wikiPageWikiLinkText "etanercept".
- Etanercept wikiPageWikiLinkText "etanercept-Enbrel".
- Etanercept atcPrefix "L04".
- Etanercept atcSuffix "AB01".
- Etanercept bioavailability "58".
- Etanercept c "2224".
- Etanercept casNumber "185243".
- Etanercept chembl "1201572".
- Etanercept chemspiderid "none".
- Etanercept drugbank "DB00005".
- Etanercept eliminationHalfLife "-475200.0".
- Etanercept h "3475".
- Etanercept kegg "D00742".
- Etanercept legalStatus "S4 , POM , ℞-only".
- Etanercept metabolism "Reticuloendothelial system".
- Etanercept molecularWeight "51234.9".
- Etanercept n "621".
- Etanercept o "698".
- Etanercept pregnancyCategory "B2 , B".
- Etanercept pubchemsubstance "10099".
- Etanercept routesOfAdministration "Subcutaneous".
- Etanercept s "36".
- Etanercept tradename "Enbrel".
- Etanercept unii "OP401G7OJC".
- Etanercept width "153".
- Etanercept wikiPageUsesTemplate Template:Commons_category.
- Etanercept wikiPageUsesTemplate Template:Drugbox.
- Etanercept wikiPageUsesTemplate Template:Drugs.com.
- Etanercept wikiPageUsesTemplate Template:Fdacite.
- Etanercept wikiPageUsesTemplate Template:Immunosuppressants.
- Etanercept wikiPageUsesTemplate Template:Reflist.
- Etanercept subject Category:Amgen.
- Etanercept subject Category:Immunosuppressants.