Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Epoxygenase> ?p ?o }
- Epoxygenase abstract "Epoxygenases are a set of membrane-bound, heme-containing cytochrome P450 (CYP P450 or just CYP) enzymes that metabolize polyunsaturated fatty acids to epoxide products that have a range of biological activities. The most thoroughly studied substrate of the CYP epoxylgenases is arachidonic acid. This polyunsaturated fatty acid is metabolized by cyclooxygenases to various prostaglandin, thromboxane, and prostacyclin metabolites in what has been termed the first pathway of eicosanoid production; it is also metabolized by various lipoxygenases to hydroxyeicosatetraenoic acids (e.g. 5-Hydroxyeicosatetraenoic acid, 12-Hydroxyeicosatetraenoic acid, 15-hydroxyicosatetraenoic acid) and leukotrienes (e.g. leukotriene B4, leukotriene C4) in what has been termed the second pathway of eicosanoid production. The metabolism of arachidonic acid to epoxyeicosatrienoic acids by the CYP epoxygenases has been termed the third pathway of eicosanoid metabolism. Like the first two pathways of eicosanoid production, this third pathway acts as a signaling pathway wherein a set of enzymes (the epoxygenases) metabolize arachidonic acid to a set of products (the eicosatrienoic acid epoxides, abbreviated as EETs, which are classified as Nonclassic eicosanoids) that act as secondary signals to work in activating their parent or nearby cells and thereby orchestrate functional responses. However, none of these three pathways is limited to metabolizing arachidonic acid to eicosanoids. Rather, they also metabolize other polyunsaturated fatty acids to products that are structurally analogous to the eicosanoids but often have different bioactivity profiles. This is particularly true for the CYP epoxygenases which in general act on a broader range of polyunsaturated fatty acids to form a broader range of metabolites than the first and second pathways of eicosanoid production. Furthermore, the latter pathways form metabolites many of which act on cells by binding with and thereby activating specific and well-characterized Receptor (biochemistry) proteins; no such receptors have been fully characterized for the epoxide metabolites. Finally, there are relatively few metabolite-forming lipoxygenases and cyclooxygenases in the first and second pathways and these oxygenase enzymes share similarity between humans and other mammalian animal models. The third pathway consists of a large number of metabolite-forming CYP epoxygenases and the human epoxygenases have important differences from those of animal models. Partly because of these differences, it has been difficult to define clear roles for the epoxygenase-epoxide pathways in human physiology and pathology.".
- Epoxygenase wikiPageID "20533479".
- Epoxygenase wikiPageLength "26368".
- Epoxygenase wikiPageOutDegree "140".
- Epoxygenase wikiPageRevisionID "707736240".
- Epoxygenase wikiPageWikiLink 12-Hydroxyeicosatetraenoic_acid.
- Epoxygenase wikiPageWikiLink 12-Hydroxyheptadecatrienoic_acid.
- Epoxygenase wikiPageWikiLink 15-Hydroxyicosatetraenoic_acid.
- Epoxygenase wikiPageWikiLink 20-Hydroxyeicosatetraenoic_acid.
- Epoxygenase wikiPageWikiLink 5-Hydroxyicosatetraenoic_acid.
- Epoxygenase wikiPageWikiLink Aceclofenac.
- Epoxygenase wikiPageWikiLink Aggregatibacter_actinomycetemcomitans.
- Epoxygenase wikiPageWikiLink Allotropes_of_oxygen.
- Epoxygenase wikiPageWikiLink Alpha-Linolenic_acid.
- Epoxygenase wikiPageWikiLink Alzheimers_disease.
- Epoxygenase wikiPageWikiLink Anti-diabetic_medication.
- Epoxygenase wikiPageWikiLink Antidepressant.
- Epoxygenase wikiPageWikiLink Arachidonic_acid.
- Epoxygenase wikiPageWikiLink Archaea.
- Epoxygenase wikiPageWikiLink Atheroma.
- Epoxygenase wikiPageWikiLink Atherosclerosis.
- Epoxygenase wikiPageWikiLink CYP1A2.
- Epoxygenase wikiPageWikiLink CYP2C11.
- Epoxygenase wikiPageWikiLink CYP2C18.
- Epoxygenase wikiPageWikiLink CYP2C19.
- Epoxygenase wikiPageWikiLink CYP2C23.
- Epoxygenase wikiPageWikiLink CYP2C8.
- Epoxygenase wikiPageWikiLink CYP2C9.
- Epoxygenase wikiPageWikiLink CYP2E1.
- Epoxygenase wikiPageWikiLink CYP2J2.
- Epoxygenase wikiPageWikiLink CYP2S1.
- Epoxygenase wikiPageWikiLink CYP4A1.
- Epoxygenase wikiPageWikiLink CYP4A11.
- Epoxygenase wikiPageWikiLink CYP4F12.
- Epoxygenase wikiPageWikiLink CYP4F8.
- Epoxygenase wikiPageWikiLink Category:Enzymes.
- Epoxygenase wikiPageWikiLink Category:Inflammations.
- Epoxygenase wikiPageWikiLink Celecoxib.
- Epoxygenase wikiPageWikiLink Chemical_nomenclature.
- Epoxygenase wikiPageWikiLink Chirality_(chemistry).
- Epoxygenase wikiPageWikiLink Cis–trans_isomerism.
- Epoxygenase wikiPageWikiLink Clopidogrel.
- Epoxygenase wikiPageWikiLink Coronaric_acid.
- Epoxygenase wikiPageWikiLink Coronary_artery_disease.
- Epoxygenase wikiPageWikiLink Cyclooxygenase.
- Epoxygenase wikiPageWikiLink Cytochrome_P450.
- Epoxygenase wikiPageWikiLink Cytochrome_P450,_family_1,_member_A1.
- Epoxygenase wikiPageWikiLink Diabetes_mellitus_type_2.
- Epoxygenase wikiPageWikiLink Diclofenac.
- Epoxygenase wikiPageWikiLink Docosahexaenoic_acid.
- Epoxygenase wikiPageWikiLink Docosapentaenoic_acid.
- Epoxygenase wikiPageWikiLink Docosatetraenoic_acid.
- Epoxygenase wikiPageWikiLink Double_bond.
- Epoxygenase wikiPageWikiLink Eicosanoid.
- Epoxygenase wikiPageWikiLink Eicosapentaenoic_acid.
- Epoxygenase wikiPageWikiLink Eicosatetraenoic_acid.
- Epoxygenase wikiPageWikiLink Enantiomer.
- Epoxygenase wikiPageWikiLink Endometriosis.
- Epoxygenase wikiPageWikiLink Endothelium-derived_relaxing_factor.
- Epoxygenase wikiPageWikiLink Epoxide.
- Epoxygenase wikiPageWikiLink Epoxide_hydrolase_2.
- Epoxygenase wikiPageWikiLink Epoxydocosapentaenoic_acid.
- Epoxygenase wikiPageWikiLink Epoxyeicosatrienoic_acid.
- Epoxygenase wikiPageWikiLink Escherichia_coli.
- Epoxygenase wikiPageWikiLink Essential_fatty_acid.
- Epoxygenase wikiPageWikiLink Estradiol.
- Epoxygenase wikiPageWikiLink Fish_oil.
- Epoxygenase wikiPageWikiLink Gram-negative_bacteria.
- Epoxygenase wikiPageWikiLink Han_Chinese.
- Epoxygenase wikiPageWikiLink Heme.
- Epoxygenase wikiPageWikiLink Hemeprotein.
- Epoxygenase wikiPageWikiLink Ibuprofen.
- Epoxygenase wikiPageWikiLink Immune_system.
- Epoxygenase wikiPageWikiLink In_vitro.
- Epoxygenase wikiPageWikiLink Indometacin.
- Epoxygenase wikiPageWikiLink Inflammation.
- Epoxygenase wikiPageWikiLink Leukotriene.
- Epoxygenase wikiPageWikiLink Leukotriene_B4.
- Epoxygenase wikiPageWikiLink Leukotriene_C4.
- Epoxygenase wikiPageWikiLink Linoleic_acid.
- Epoxygenase wikiPageWikiLink Lipoxygenase.
- Epoxygenase wikiPageWikiLink Lornoxicam.
- Epoxygenase wikiPageWikiLink Macrophage.
- Epoxygenase wikiPageWikiLink Meloxicam.
- Epoxygenase wikiPageWikiLink Microsome.
- Epoxygenase wikiPageWikiLink Monocyte.
- Epoxygenase wikiPageWikiLink Naproxen.
- Epoxygenase wikiPageWikiLink Nonclassic_eicosanoid.
- Epoxygenase wikiPageWikiLink Nonsteroidal_anti-inflammatory_drug.
- Epoxygenase wikiPageWikiLink Null_allele.
- Epoxygenase wikiPageWikiLink Omega-3_fatty_acid.
- Epoxygenase wikiPageWikiLink Omega-6_fatty_acid.
- Epoxygenase wikiPageWikiLink Phenotype.
- Epoxygenase wikiPageWikiLink Piroxicam.
- Epoxygenase wikiPageWikiLink Polymorphism_(biology).
- Epoxygenase wikiPageWikiLink Polyunsaturated_fat.
- Epoxygenase wikiPageWikiLink Polyunsaturated_fatty_acid.
- Epoxygenase wikiPageWikiLink Promoter_(genetics).
- Epoxygenase wikiPageWikiLink Prostacyclin.
- Epoxygenase wikiPageWikiLink Prostaglandin.