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- Epithelial_polarity abstract "Cell polarity is a fundamental feature of many types of cells. Epithelial cells are one example of a polarized cell type, featuring distinct 'apical', 'lateral' and 'basal' plasma membrane domains. Epithelial cells connect to one another via their lateral membranes to form epithelial sheets that line cavities and surfaces throughout the animal body. Each plasma membrane domain has a distinct protein composition, giving them distinct properties and allowing directional transport of molecules across the epithelial sheet. How epithelial cells generate and maintain polarity remains unclear, but certain molecules have been found to play a key role.A variety of molecules are located at the apical membrane, but only a few key molecules act as determinants that are required to maintain the identity of the apical membrane and, thus, epithelial polarity. These molecules are the proteins Cdc42, atypical protein kinase C (aPKC), Par6, Par3/Bazooka/ASIP. Crumbs, \"Stardust\" and protein at tight junctions (PATJ). These molecules appear to form two distinct complexes: an aPKC-Par3-Par6 \"aPKC\" (or \"Par\") complex that also interacts with Cdc42; and a Crumbs-Stardust-PATJ \"Crumbs\" complex. Of these two complexes, the aPKC complex is the most important for epithelial polarity, being required even when the Crumbs complex is not. Crumbs is the only transmembrane protein in this list and the Crumbs complex serves as an apical cue to keep the aPKC complex apical during complex cellular shape changes.".
- Epithelial_polarity wikiPageExternalLink NBK21054.
- Epithelial_polarity wikiPageID "22762505".
- Epithelial_polarity wikiPageLength "8484".
- Epithelial_polarity wikiPageOutDegree "33".
- Epithelial_polarity wikiPageRevisionID "667614584".
- Epithelial_polarity wikiPageWikiLink Actin.
- Epithelial_polarity wikiPageWikiLink Adherens_junction.
- Epithelial_polarity wikiPageWikiLink Alpha_catenin.
- Epithelial_polarity wikiPageWikiLink Basement_membrane.
- Epithelial_polarity wikiPageWikiLink Beta-catenin.
- Epithelial_polarity wikiPageWikiLink CDC42.
- Epithelial_polarity wikiPageWikiLink CDH1_(gene).
- Epithelial_polarity wikiPageWikiLink Cadherin.
- Epithelial_polarity wikiPageWikiLink Category:Cell_biology.
- Epithelial_polarity wikiPageWikiLink Cell_(biology).
- Epithelial_polarity wikiPageWikiLink Cell_adhesion_molecule.
- Epithelial_polarity wikiPageWikiLink Cell_membrane.
- Epithelial_polarity wikiPageWikiLink Drosophila_melanogaster.
- Epithelial_polarity wikiPageWikiLink Epithelium.
- Epithelial_polarity wikiPageWikiLink Exocytosis.
- Epithelial_polarity wikiPageWikiLink Glucose.
- Epithelial_polarity wikiPageWikiLink Integrin.
- Epithelial_polarity wikiPageWikiLink Interstitial_fluid.
- Epithelial_polarity wikiPageWikiLink Lumen_(anatomy).
- Epithelial_polarity wikiPageWikiLink Metabolism.
- Epithelial_polarity wikiPageWikiLink Nephron.
- Epithelial_polarity wikiPageWikiLink PARD3.
- Epithelial_polarity wikiPageWikiLink PARD6A.
- Epithelial_polarity wikiPageWikiLink Phosphatidylinositol.
- Epithelial_polarity wikiPageWikiLink Positive_feedback.
- Epithelial_polarity wikiPageWikiLink Protein_kinase_C.
- Epithelial_polarity wikiPageWikiLink Saccharomyces_cerevisiae.
- Epithelial_polarity wikiPageWikiLink Urine.
- Epithelial_polarity wikiPageWikiLink Vesicle_(biology_and_chemistry).
- Epithelial_polarity wikiPageWikiLinkText "Epithelial polarity".
- Epithelial_polarity wikiPageWikiLinkText "apical membrane".
- Epithelial_polarity wikiPageWikiLinkText "apico-basal axis".
- Epithelial_polarity wikiPageWikiLinkText "basal membrane".
- Epithelial_polarity wikiPageWikiLinkText "basal membranes".
- Epithelial_polarity wikiPageWikiLinkText "basolateral membrane".
- Epithelial_polarity wikiPageWikiLinkText "cell polarity".
- Epithelial_polarity wikiPageWikiLinkText "epithelial polarity".
- Epithelial_polarity wikiPageWikiLinkText "polarised cells".
- Epithelial_polarity wikiPageUsesTemplate Template:Cite_book.
- Epithelial_polarity wikiPageUsesTemplate Template:Cn.
- Epithelial_polarity wikiPageUsesTemplate Template:Reflist.
- Epithelial_polarity subject Category:Cell_biology.
- Epithelial_polarity hypernym Feature.
- Epithelial_polarity type Work.
- Epithelial_polarity comment "Cell polarity is a fundamental feature of many types of cells. Epithelial cells are one example of a polarized cell type, featuring distinct 'apical', 'lateral' and 'basal' plasma membrane domains. Epithelial cells connect to one another via their lateral membranes to form epithelial sheets that line cavities and surfaces throughout the animal body.".
- Epithelial_polarity label "Epithelial polarity".
- Epithelial_polarity sameAs Q5383698.
- Epithelial_polarity sameAs 上皮細胞極性.
- Epithelial_polarity sameAs m.05zr116.
- Epithelial_polarity sameAs Q5383698.
- Epithelial_polarity wasDerivedFrom Epithelial_polarity?oldid=667614584.
- Epithelial_polarity isPrimaryTopicOf Epithelial_polarity.