Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Enzyme_inhibitor> ?p ?o }
- Enzyme_inhibitor abstract "An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. They are also used in pesticides. Not all molecules that bind to enzymes are inhibitors; enzyme activators bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.The binding of an inhibitor can stop a substrate from entering the enzyme's active site and/or hinder the enzyme from catalyzing its reaction. Inhibitor binding is either reversible or irreversible. Irreversible inhibitors usually react with the enzyme and change it chemically (e.g. via covalent bond formation). These inhibitors modify key amino acid residues needed for enzymatic activity. In contrast, reversible inhibitors bind non-covalently and different types of inhibition are produced depending on whether these inhibitors bind to the enzyme, the enzyme-substrate complex, or both.Many drug molecules are enzyme inhibitors, so their discovery and improvement is an active area of research in biochemistry and pharmacology. A medicinal enzyme inhibitor is often judged by its specificity (its lack of binding to other proteins) and its potency (its dissociation constant, which indicates the concentration needed to inhibit the enzyme). A high specificity and potency ensure that a drug will have few side effects and thus low toxicity.Enzyme inhibitors also occur naturally and are involved in the regulation of metabolism. For example, enzymes in a metabolic pathway can be inhibited by downstream products. This type of negative feedback slows the production line when products begin to build up and is an important way to maintain homeostasis in a cell. Other cellular enzyme inhibitors are proteins that specifically bind to and inhibit an enzyme target. This can help control enzymes that may be damaging to a cell, like proteases or nucleases. A well-characterised example of this is the ribonuclease inhibitor, which binds to ribonucleases in one of the tightest known protein–protein interactions. Natural enzyme inhibitors can also be poisons and are used as defences against predators or as ways of killing prey.".
- Enzyme_inhibitor thumbnail HIV_protease_with_bound_ritonavir.png?width=300.
- Enzyme_inhibitor wikiPageExternalLink pubchem.ncbi.nlm.nih.gov.
- Enzyme_inhibitor wikiPageExternalLink contents_chap3.html.
- Enzyme_inhibitor wikiPageExternalLink enzyme-kinetics.html.
- Enzyme_inhibitor wikiPageExternalLink www.bindingdb.org.
- Enzyme_inhibitor wikiPageExternalLink www.brenda.uni-koeln.de.
- Enzyme_inhibitor wikiPageExternalLink p6.
- Enzyme_inhibitor wikiPageExternalLink explore.do?structureId=1GXF.
- Enzyme_inhibitor wikiPageExternalLink explore.do?structureId=1HXW.
- Enzyme_inhibitor wikiPageExternalLink explore.do?structureId=1PWC.
- Enzyme_inhibitor wikiPageExternalLink index.html.
- Enzyme_inhibitor wikiPageID "5464960".
- Enzyme_inhibitor wikiPageLength "56746".
- Enzyme_inhibitor wikiPageOutDegree "273".
- Enzyme_inhibitor wikiPageRevisionID "705337604".
- Enzyme_inhibitor wikiPageWikiLink Acetate.
- Enzyme_inhibitor wikiPageWikiLink Acetolactate_synthase.
- Enzyme_inhibitor wikiPageWikiLink Acetylcholine.
- Enzyme_inhibitor wikiPageWikiLink Acetylcholine_receptor.
- Enzyme_inhibitor wikiPageWikiLink Acetylcholinesterase.
- Enzyme_inhibitor wikiPageWikiLink Aciclovir.
- Enzyme_inhibitor wikiPageWikiLink Active_site.
- Enzyme_inhibitor wikiPageWikiLink Activity-based_proteomics.
- Enzyme_inhibitor wikiPageWikiLink Adenosine_diphosphate.
- Enzyme_inhibitor wikiPageWikiLink Adenosine_triphosphate.
- Enzyme_inhibitor wikiPageWikiLink Adverse_drug_reaction.
- Enzyme_inhibitor wikiPageWikiLink African_trypanosomiasis.
- Enzyme_inhibitor wikiPageWikiLink Aldehyde.
- Enzyme_inhibitor wikiPageWikiLink Algal_bloom.
- Enzyme_inhibitor wikiPageWikiLink Alkene.
- Enzyme_inhibitor wikiPageWikiLink Allopurinol.
- Enzyme_inhibitor wikiPageWikiLink Allosteric_regulation.
- Enzyme_inhibitor wikiPageWikiLink Alpha-Amanitin.
- Enzyme_inhibitor wikiPageWikiLink Amanita_phalloides.
- Enzyme_inhibitor wikiPageWikiLink Amino_acid.
- Enzyme_inhibitor wikiPageWikiLink Anticonvulsant.
- Enzyme_inhibitor wikiPageWikiLink Antimetabolite.
- Enzyme_inhibitor wikiPageWikiLink Antinutrient.
- Enzyme_inhibitor wikiPageWikiLink Atropa_belladonna.
- Enzyme_inhibitor wikiPageWikiLink Atropine.
- Enzyme_inhibitor wikiPageWikiLink Bacterial_cell_structure.
- Enzyme_inhibitor wikiPageWikiLink Barnase.
- Enzyme_inhibitor wikiPageWikiLink Barstar.
- Enzyme_inhibitor wikiPageWikiLink Biochemistry.
- Enzyme_inhibitor wikiPageWikiLink Bioinformatics.
- Enzyme_inhibitor wikiPageWikiLink Biomolecular_structure.
- Enzyme_inhibitor wikiPageWikiLink CGMP-specific_phosphodiesterase_type_5.
- Enzyme_inhibitor wikiPageWikiLink Carbamate.
- Enzyme_inhibitor wikiPageWikiLink Carotenoid.
- Enzyme_inhibitor wikiPageWikiLink Catabolism.
- Enzyme_inhibitor wikiPageWikiLink Catalysis.
- Enzyme_inhibitor wikiPageWikiLink Catalytic_triad.
- Enzyme_inhibitor wikiPageWikiLink Category:Enzyme_inhibitors.
- Enzyme_inhibitor wikiPageWikiLink Category:Medicinal_chemistry.
- Enzyme_inhibitor wikiPageWikiLink Category:Metabolism.
- Enzyme_inhibitor wikiPageWikiLink Cell_(biology).
- Enzyme_inhibitor wikiPageWikiLink Cell_signaling.
- Enzyme_inhibitor wikiPageWikiLink Chemical_synapse.
- Enzyme_inhibitor wikiPageWikiLink Chemical_warfare.
- Enzyme_inhibitor wikiPageWikiLink Chemotherapy.
- Enzyme_inhibitor wikiPageWikiLink Chlorpyrifos.
- Enzyme_inhibitor wikiPageWikiLink Choline.
- Enzyme_inhibitor wikiPageWikiLink Cholinesterase.
- Enzyme_inhibitor wikiPageWikiLink Combinatorial_chemistry.
- Enzyme_inhibitor wikiPageWikiLink Competitive_antagonist.
- Enzyme_inhibitor wikiPageWikiLink Competitive_inhibition.
- Enzyme_inhibitor wikiPageWikiLink Conformational_change.
- Enzyme_inhibitor wikiPageWikiLink Conformational_isomerism.
- Enzyme_inhibitor wikiPageWikiLink Corpus_cavernosum_penis.
- Enzyme_inhibitor wikiPageWikiLink Covalent_adducts.
- Enzyme_inhibitor wikiPageWikiLink Covalent_bond.
- Enzyme_inhibitor wikiPageWikiLink Cyclic_guanosine_monophosphate.
- Enzyme_inhibitor wikiPageWikiLink Cysteine.
- Enzyme_inhibitor wikiPageWikiLink Cytoskeleton.
- Enzyme_inhibitor wikiPageWikiLink DD-transpeptidase.
- Enzyme_inhibitor wikiPageWikiLink DNA_replication.
- Enzyme_inhibitor wikiPageWikiLink Denaturation_(biochemistry).
- Enzyme_inhibitor wikiPageWikiLink Dihydrofolate_reductase.
- Enzyme_inhibitor wikiPageWikiLink Diisopropyl_fluorophosphate.
- Enzyme_inhibitor wikiPageWikiLink Disinfectant.
- Enzyme_inhibitor wikiPageWikiLink Dissociation_constant.
- Enzyme_inhibitor wikiPageWikiLink Docking_(molecular).
- Enzyme_inhibitor wikiPageWikiLink Dopamine.
- Enzyme_inhibitor wikiPageWikiLink Drug_design.
- Enzyme_inhibitor wikiPageWikiLink Drug_development.
- Enzyme_inhibitor wikiPageWikiLink EPSP_synthase.
- Enzyme_inhibitor wikiPageWikiLink Eadie–Hofstee_diagram.
- Enzyme_inhibitor wikiPageWikiLink Edrophonium.
- Enzyme_inhibitor wikiPageWikiLink Eflornithine.
- Enzyme_inhibitor wikiPageWikiLink Eggplant.
- Enzyme_inhibitor wikiPageWikiLink Electrophile.
- Enzyme_inhibitor wikiPageWikiLink Enzyme.
- Enzyme_inhibitor wikiPageWikiLink Enzyme_activator.
- Enzyme_inhibitor wikiPageWikiLink Enzyme_assay.
- Enzyme_inhibitor wikiPageWikiLink Enzyme_induction_and_inhibition.
- Enzyme_inhibitor wikiPageWikiLink Enzyme_kinetics.
- Enzyme_inhibitor wikiPageWikiLink Exponential_decay.
- Enzyme_inhibitor wikiPageWikiLink Fatty_acid.
- Enzyme_inhibitor wikiPageWikiLink Feedback.