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- Enzyme-activated_MR_contrast_agents abstract "Molecular imaging is broadly defined as the visualization of molecular and cellular processes on either a macro- or microscopic level. Because of its high spatial resolution and ability to noninvasively visualize internal organs, magnetic resonance (MR) imaging is widely believed to be an ideal platform for in vivo molecular imaging. For this reason, MR contrast agents that can detect molecular events are an active field of research. One group of compounds that has shown particular promise is enzyme-activated MR contrast agents.Enzyme-activated MR contrast agents are compounds that cause a detectable change in image intensity when in the presence of the active form of a certain enzyme. This makes them useful for in vivo assays of enzyme activity. They are distinguished from current, clinical MR contrast agents that give only anatomical information, such as aqueous gadolinium compounds, by their ability to make molecular processes visible. Enzyme-activated contrast agents are powerful tools for molecular imaging. To date, β-galactosidase-activated contrast agents have attracted the most attention in the literature, although there no theoretical reason that other enzymes could not be used to activate contrast agents. Also, mechanisms other than enzyme activation, such as Ca2+-dependent activation, can theoretically be used.In general, enzyme-activated agents contain a paramagnetic metal ion which can affect the T1 or T2 relaxation times for nearby water molecules. However, the metal ions are unable to interact with the water until an enzyme-catalyzed reaction takes place. Steric hindrance or coordination with other ions prevents water from accessing the paramagnetic center prior to the enzymatic reaction.".
- Enzyme-activated_MR_contrast_agents thumbnail Alpha_series.svg?width=300.
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- Enzyme-activated_MR_contrast_agents wikiPageOutDegree "23".
- Enzyme-activated_MR_contrast_agents wikiPageRevisionID "528958869".
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink African_clawed_frog.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Beta-galactosidase.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Cancer.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Carbonate.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Carboxylic_acid.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Cardiovascular_disease.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Category:Imaging.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Enzyme.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Fixation_(histology).
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Fructose_bisphosphatase_deficiency.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Gadolinium.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Glutamic_acid.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Glycosidic_bond.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Immunostaining.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Magnetic_resonance_imaging.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Messenger_RNA.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Molecular_imaging.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Paraffin_wax.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Pipette.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Spin–lattice_relaxation.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink Spin–spin_relaxation.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink File:Alpha_series.svg.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLink File:Alpha_series_rxn.svg.
- Enzyme-activated_MR_contrast_agents wikiPageWikiLinkText "Enzyme-activated MR contrast agents".
- Enzyme-activated_MR_contrast_agents wikiPageUsesTemplate Template:Orphan.
- Enzyme-activated_MR_contrast_agents subject Category:Imaging.
- Enzyme-activated_MR_contrast_agents type Redirect.
- Enzyme-activated_MR_contrast_agents comment "Molecular imaging is broadly defined as the visualization of molecular and cellular processes on either a macro- or microscopic level. Because of its high spatial resolution and ability to noninvasively visualize internal organs, magnetic resonance (MR) imaging is widely believed to be an ideal platform for in vivo molecular imaging. For this reason, MR contrast agents that can detect molecular events are an active field of research.".
- Enzyme-activated_MR_contrast_agents label "Enzyme-activated MR contrast agents".
- Enzyme-activated_MR_contrast_agents sameAs Q5381539.
- Enzyme-activated_MR_contrast_agents sameAs m.03qjy86.
- Enzyme-activated_MR_contrast_agents sameAs Q5381539.
- Enzyme-activated_MR_contrast_agents wasDerivedFrom Enzyme-activated_MR_contrast_agents?oldid=528958869.
- Enzyme-activated_MR_contrast_agents depiction Alpha_series.svg.
- Enzyme-activated_MR_contrast_agents isPrimaryTopicOf Enzyme-activated_MR_contrast_agents.