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- Enteric_coating abstract "An enteric coating (also known as gastro-resistant drugs) is a polymer barrier applied on oral medication that prevents its dissolution or disintegration in the gastric environment. This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). Some drugs are, in fact, unstable at the acid gastric pH, and need to be protected from degradation. Enteric coating is also an effective method to obtain drug targeting. Other drugs such as some anthelmintics may, in fact, require to reach a high concentration in a specific district of the intestine. Enteric coating may also be used during studies as an useful research tool to determine drug absorption. Enteric coated medications pertain to the \"delayed action\" dosage form category. It should be noted that from a pharmacological point of view the term \"enteric coating\" is not entirely correct, as gastric resistance can be also obtained by adding enteric polymeric systems to the matrix of the dosage form. Tablets, mini-tablets, pellets and granules (usually filled into capsule shells) are the most common enteric-coated dosage forms.Most enteric coatings work by presenting a surface that is stable at the highly acidic pH found in the stomach, but breaks down rapidly at a less acidic (relatively more basic) pH. For example, they will not dissolve in the gastric acids of the stomach (pH ~3), but they will in the alkaline (pH 7-9) environment present in the small intestine. The time required for an enteric-coated dosage form to reach the intestine mostly depends on the presence and type of food in the stomach. It varies highly from 30 minutes up to 7 hours, with an average time of 6 hours. Although some studies indicated that larger sized dosage forms may require additional time for gastric emptying, others suggested that the size, shape, or volume of the tablet possess no significant effects instead. Enteric coated granules emptying rate is, however, less affected by the presence of food and present the more uniform release and reproducible transit time typical of the multiparticulates dispersion.By preventing the drug from dissolving into the stomach, enteric coating may protect gastric mucosa from the irritating effects of the medication itself. When the drug reaches the neutral or alkaline environment of the intestine, its active ingredients can then dissolve and become available for absorption into the bloodstream. Drugs that have an irritant effect on the stomach, such as aspirin or potassium chloride, can be coated with a substance that will dissolve only in the small intestine. However, it has been shown that enteric coated aspirin may lead to incomplete inhibition of platelets. Likewise, certain groups of proton pump inhibitors (esomeprazole, omeprazole, pantoprazole and all grouped azoles) are acid-activated. For such types of drugs, enteric coating added to the formulation tends to avoid activation in the mouth and esophagus.Materials used for enteric coatings include fatty acids, waxes, shellac, plastics, and plant fibers. Conventional materials used are solutions of film resins. However as the solvents for such solutions are organic solvents, there's a concern about the toxicity potential of the traces of the residual solvents in the tablet coating.The first form of gastro-resistant coating was introduced by Unna in 1884 in the form of keratin-coated pills, although it was later discovered that they weren't able to withstand gastric digestion. Salol was also used by Ceppi as one of the first forms of enteric coating. However, the first material that was extensively used as enteric coating agent was shellac, since its introduction in 1930. Properly treated or hydrolyzed shellac showed different enteric release properties.Recently, some companies have begun to apply enteric coatings to fish oil (omega-3 fatty acids) supplements. The coating prevents the fish oil capsules from being digested in the stomach, which has been known to cause a fishy reflux.Sometimes the abbreviation \"EC\" is added beside the name of the drug to indicate that it has an enteric coating.".
- Enteric_coating wikiPageID "2910903".
- Enteric_coating wikiPageLength "10005".
- Enteric_coating wikiPageOutDegree "44".
- Enteric_coating wikiPageRevisionID "707580496".
- Enteric_coating wikiPageWikiLink Activation.
- Enteric_coating wikiPageWikiLink Alginic_acid.
- Enteric_coating wikiPageWikiLink Anthelmintic.
- Enteric_coating wikiPageWikiLink Aspirin.
- Enteric_coating wikiPageWikiLink Base_(chemistry).
- Enteric_coating wikiPageWikiLink Capsule_(pharmacy).
- Enteric_coating wikiPageWikiLink Category:Coatings.
- Enteric_coating wikiPageWikiLink Category:Pharmacokinetics.
- Enteric_coating wikiPageWikiLink Category:Pharmacy.
- Enteric_coating wikiPageWikiLink Category:Polymers.
- Enteric_coating wikiPageWikiLink Cellulose_acetate_phthalate.
- Enteric_coating wikiPageWikiLink Digestion.
- Enteric_coating wikiPageWikiLink Dispersion_(chemistry).
- Enteric_coating wikiPageWikiLink Dosage_form.
- Enteric_coating wikiPageWikiLink Esomeprazole.
- Enteric_coating wikiPageWikiLink Esophagus.
- Enteric_coating wikiPageWikiLink Fatty_acid.
- Enteric_coating wikiPageWikiLink Fish_oil.
- Enteric_coating wikiPageWikiLink Gastric_mucosa.
- Enteric_coating wikiPageWikiLink Gastroesophageal_reflux_disease.
- Enteric_coating wikiPageWikiLink Hypromellose.
- Enteric_coating wikiPageWikiLink Keratin.
- Enteric_coating wikiPageWikiLink Methyl_acrylate.
- Enteric_coating wikiPageWikiLink Mouth.
- Enteric_coating wikiPageWikiLink Omega-3_fatty_acid.
- Enteric_coating wikiPageWikiLink Omeprazole.
- Enteric_coating wikiPageWikiLink PH.
- Enteric_coating wikiPageWikiLink Pantoprazole.
- Enteric_coating wikiPageWikiLink Pharmaceutical_drug.
- Enteric_coating wikiPageWikiLink Phenyl_salicylate.
- Enteric_coating wikiPageWikiLink Phthalate.
- Enteric_coating wikiPageWikiLink Plastic.
- Enteric_coating wikiPageWikiLink Platelet.
- Enteric_coating wikiPageWikiLink Polyvinyl_acetate_phthalate.
- Enteric_coating wikiPageWikiLink Potassium_chloride.
- Enteric_coating wikiPageWikiLink Proton-pump_inhibitor.
- Enteric_coating wikiPageWikiLink Shellac.
- Enteric_coating wikiPageWikiLink Small_intestine.
- Enteric_coating wikiPageWikiLink Stomach.
- Enteric_coating wikiPageWikiLink Tablet_(pharmacy).
- Enteric_coating wikiPageWikiLink Wax.
- Enteric_coating wikiPageWikiLink Zein.
- Enteric_coating wikiPageWikiLinkText "Enteric coated".
- Enteric_coating wikiPageWikiLinkText "Enteric coating".
- Enteric_coating wikiPageWikiLinkText "Enteric release coating".
- Enteric_coating wikiPageWikiLinkText "Enteric".
- Enteric_coating wikiPageWikiLinkText "Enteric-coated".
- Enteric_coating wikiPageWikiLinkText "enteric coated".
- Enteric_coating wikiPageWikiLinkText "enteric coating".
- Enteric_coating wikiPageWikiLinkText "enteric formulations".
- Enteric_coating wikiPageWikiLinkText "enteric-coated".
- Enteric_coating wikiPageWikiLinkText "enterically".
- Enteric_coating wikiPageUsesTemplate Template:Cleanup_rewrite.
- Enteric_coating wikiPageUsesTemplate Template:Expert_subject.
- Enteric_coating wikiPageUsesTemplate Template:Multiple_issues.
- Enteric_coating wikiPageUsesTemplate Template:Refimprove.
- Enteric_coating wikiPageUsesTemplate Template:Reflist.
- Enteric_coating subject Category:Coatings.
- Enteric_coating subject Category:Pharmacokinetics.
- Enteric_coating subject Category:Pharmacy.
- Enteric_coating subject Category:Polymers.
- Enteric_coating hypernym Barrier.
- Enteric_coating type ArchitecturalStructure.
- Enteric_coating type Coating.
- Enteric_coating type Polymer.
- Enteric_coating type Process.
- Enteric_coating type Science.
- Enteric_coating type Substance.
- Enteric_coating comment "An enteric coating (also known as gastro-resistant drugs) is a polymer barrier applied on oral medication that prevents its dissolution or disintegration in the gastric environment. This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). Some drugs are, in fact, unstable at the acid gastric pH, and need to be protected from degradation.".
- Enteric_coating label "Enteric coating".
- Enteric_coating sameAs Q4179213.
- Enteric_coating sameAs تغليف_معوي.
- Enteric_coating sameAs Recobriment_entèric.
- Enteric_coating sameAs Gélule_gastro-résistante.
- Enteric_coating sameAs Tabletka_powlekana.
- Enteric_coating sameAs m.08b_l2.
- Enteric_coating sameAs Желудочно-резистентные_таблетки.
- Enteric_coating sameAs Gastrorezistentnost.
- Enteric_coating sameAs Q4179213.
- Enteric_coating wasDerivedFrom Enteric_coating?oldid=707580496.
- Enteric_coating isPrimaryTopicOf Enteric_coating.