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- Endothelin_1 abstract "Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin. Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.".
- Endothelin_1 entrezgene "1906".
- Endothelin_1 wikiPageID "14033394".
- Endothelin_1 wikiPageLength "2427".
- Endothelin_1 wikiPageOutDegree "10".
- Endothelin_1 wikiPageRevisionID "701483415".
- Endothelin_1 wikiPageWikiLink Bosentan.
- Endothelin_1 wikiPageWikiLink Endothelin.
- Endothelin_1 wikiPageWikiLink Endothelium.
- Endothelin_1 wikiPageWikiLink Gene.
- Endothelin_1 wikiPageWikiLink Protein.
- Endothelin_1 wikiPageWikiLink Protein_isoform.
- Endothelin_1 wikiPageWikiLink Proteolysis.
- Endothelin_1 wikiPageWikiLink Pulmonary_hypertension.
- Endothelin_1 wikiPageWikiLink Vasoconstriction.
- Endothelin_1 wikiPageWikiLinkText "EDN1".
- Endothelin_1 wikiPageWikiLinkText "Endothelin 1".
- Endothelin_1 wikiPageWikiLinkText "endothelin 1".
- Endothelin_1 wikiPageUsesTemplate Template:Cite_journal.
- Endothelin_1 wikiPageUsesTemplate Template:Gene-6-stub.
- Endothelin_1 wikiPageUsesTemplate Template:NLM_content.
- Endothelin_1 wikiPageUsesTemplate Template:PBB.
- Endothelin_1 wikiPageUsesTemplate Template:Peptidergics.
- Endothelin_1 wikiPageUsesTemplate Template:Refbegin.
- Endothelin_1 wikiPageUsesTemplate Template:Refend.
- Endothelin_1 wikiPageUsesTemplate Template:Reflist.
- Endothelin_1 hypernym Protein.
- Endothelin_1 type Biomolecule.
- Endothelin_1 type Protein.
- Endothelin_1 type Institute.
- Endothelin_1 type Source.
- Endothelin_1 type Thing.
- Endothelin_1 type Q206229.
- Endothelin_1 type Q8054.
- Endothelin_1 comment "Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin. Preproendothelin is precursor of the peptide ET-1.".
- Endothelin_1 label "Endothelin 1".
- Endothelin_1 sameAs Q18023132.
- Endothelin_1 sameAs Endotelina_1.
- Endothelin_1 sameAs m.03crmjl.
- Endothelin_1 sameAs Q18023132.
- Endothelin_1 wasDerivedFrom Endothelin_1?oldid=701483415.
- Endothelin_1 isPrimaryTopicOf Endothelin_1.