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- Embryoid_body abstract "Embryoid bodies (EBs) are three-dimensional aggregates of pluripotent stem cells. The pluripotent cell types that comprise embryoid bodies include embryonic stem cells (ESCs) derived from the blastocyst stage of embryos from mouse (mESC), primate, and human (hESC) sources. Additionally, EBs can be formed from embryonic stem cells derived through alternative techniques, including somatic cell nuclear transfer or the reprogramming of somatic cells to yield induced pluripotent stem cells (iPS). Similar to ESCs cultured in monolayer formats, ESCs within embryoid bodies undergo differentiation and cell specification along the three germ lineages – endoderm, ectoderm, and mesoderm – which comprise all somatic cell types.In contrast to monolayer cultures, however, the spheroid structures that are formed when ESCs aggregate enables the non-adherent culture of EBs in suspension, making EB cultures inherently scalable, which is useful for bioprocessing approaches, whereby large yields of cells can be produced for potential clinical applications. Additionally, although EBs largely exhibit heterogeneous patterns of differentiated cell types, ESCs are capable of responding to similar cues that direct embryonic development. Therefore, the three-dimensional structure, including the establishment of complex cell adhesions and paracrine signaling within the EB microenvironment, enables differentiation and morphogenesis which yields microtissues that are similar to native tissue structures. Such microtissues are promising to directly or indirectly repair damaged or diseased tissue in regenerative medicine applications, as well as for in vitro testing in the pharmaceutical industry and as a model of embryonic development.".
- Embryoid_body thumbnail MESC_EBs.jpg?width=300.
- Embryoid_body wikiPageID "1195514".
- Embryoid_body wikiPageLength "46738".
- Embryoid_body wikiPageOutDegree "64".
- Embryoid_body wikiPageRevisionID "705430107".
- Embryoid_body wikiPageWikiLink Agar.
- Embryoid_body wikiPageWikiLink Agonist.
- Embryoid_body wikiPageWikiLink Anatomical_terms_of_location.
- Embryoid_body wikiPageWikiLink Antagonist.
- Embryoid_body wikiPageWikiLink Barack_Obama.
- Embryoid_body wikiPageWikiLink Basement_membrane.
- Embryoid_body wikiPageWikiLink Blastocyst.
- Embryoid_body wikiPageWikiLink CDH1_(gene).
- Embryoid_body wikiPageWikiLink Cardiac_muscle_cell.
- Embryoid_body wikiPageWikiLink Category:Articles_containing_video_clips.
- Embryoid_body wikiPageWikiLink Category:Stem_cells.
- Embryoid_body wikiPageWikiLink Cell_adhesion.
- Embryoid_body wikiPageWikiLink Cell_culture.
- Embryoid_body wikiPageWikiLink Cell_junction.
- Embryoid_body wikiPageWikiLink Cell_potency.
- Embryoid_body wikiPageWikiLink Cell_signaling.
- Embryoid_body wikiPageWikiLink Cellular_differentiation.
- Embryoid_body wikiPageWikiLink Cerebral_organoid.
- Embryoid_body wikiPageWikiLink Dickey-Wicker_Amendment.
- Embryoid_body wikiPageWikiLink Embryogenesis.
- Embryoid_body wikiPageWikiLink Embryonic_stem_cell.
- Embryoid_body wikiPageWikiLink Endoderm.
- Embryoid_body wikiPageWikiLink Epiblast.
- Embryoid_body wikiPageWikiLink Epithelial–mesenchymal_transition.
- Embryoid_body wikiPageWikiLink Epithelium.
- Embryoid_body wikiPageWikiLink Executive_order.
- Embryoid_body wikiPageWikiLink Extracellular_matrix.
- Embryoid_body wikiPageWikiLink Fetal_bovine_serum.
- Embryoid_body wikiPageWikiLink Fluid_dynamics.
- Embryoid_body wikiPageWikiLink Gastrulation.
- Embryoid_body wikiPageWikiLink Gelatin.
- Embryoid_body wikiPageWikiLink Germ_layer.
- Embryoid_body wikiPageWikiLink Immortalised_cell_line.
- Embryoid_body wikiPageWikiLink Induced_pluripotent_stem_cell.
- Embryoid_body wikiPageWikiLink Induced_stem_cells.
- Embryoid_body wikiPageWikiLink Inner_cell_mass.
- Embryoid_body wikiPageWikiLink Laminin.
- Embryoid_body wikiPageWikiLink Mesoderm.
- Embryoid_body wikiPageWikiLink Morphogenesis.
- Embryoid_body wikiPageWikiLink National_Institutes_of_Health.
- Embryoid_body wikiPageWikiLink Neural_crest.
- Embryoid_body wikiPageWikiLink Neurite.
- Embryoid_body wikiPageWikiLink Nuclear_transfer.
- Embryoid_body wikiPageWikiLink Rho-associated_protein_kinase.
- Embryoid_body wikiPageWikiLink Somatic_(biology).
- Embryoid_body wikiPageWikiLink Stem_cell.
- Embryoid_body wikiPageWikiLink Stem_cell_controversy.
- Embryoid_body wikiPageWikiLink Stem_cell_laws_and_policy_in_the_United_States.
- Embryoid_body wikiPageWikiLink Transforming_growth_factor_beta.
- Embryoid_body wikiPageWikiLink Transport_phenomena.
- Embryoid_body wikiPageWikiLink Type_IV_collagen.
- Embryoid_body wikiPageWikiLink Wnt_signaling_pathway.
- Embryoid_body wikiPageWikiLink File:MESC_EBs.jpg.
- Embryoid_body wikiPageWikiLink File:The-L-type-Ca2+-Channels-Blocker-Nifedipine-Represses-Mesodermal-Fate-Determination-in-Murine-pone.0053407.s007.ogv.
- Embryoid_body wikiPageWikiLinkText "Embryoid bodies".
- Embryoid_body wikiPageWikiLinkText "Embryoid body".
- Embryoid_body wikiPageWikiLinkText "embryoid bodies".
- Embryoid_body wikiPageWikiLinkText "embryoid body".
- Embryoid_body wikiPageUsesTemplate Template:Columns-list.
- Embryoid_body wikiPageUsesTemplate Template:Main.
- Embryoid_body wikiPageUsesTemplate Template:Reflist.
- Embryoid_body subject Category:Articles_containing_video_clips.
- Embryoid_body subject Category:Stem_cells.
- Embryoid_body hypernym Aggregates.
- Embryoid_body comment "Embryoid bodies (EBs) are three-dimensional aggregates of pluripotent stem cells. The pluripotent cell types that comprise embryoid bodies include embryonic stem cells (ESCs) derived from the blastocyst stage of embryos from mouse (mESC), primate, and human (hESC) sources.".
- Embryoid_body label "Embryoid body".
- Embryoid_body sameAs Q3384920.
- Embryoid_body sameAs m.04gcs0.
- Embryoid_body sameAs Q3384920.
- Embryoid_body wasDerivedFrom Embryoid_body?oldid=705430107.
- Embryoid_body depiction MESC_EBs.jpg.
- Embryoid_body isPrimaryTopicOf Embryoid_body.