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- Elagolix abstract "Elagolix (INN, USAN) (former developmental code names NBI-56418, ABT-620) is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM) that is under development for clinical use by Neurocrine Biosciences and AbbVie. As of 2015, it is in phase III clinical trials for the treatment of endometriosis and uterine leiomyoma.[1] The drug was also under investigation for the treatment of prostate cancer and benign prostatic hyperplasia, but development for these indications was ultimately not pursued.[2] Elagolix is regarded as the frontrunner of a new class of GnRH inhibitors that have been denoted as second-generation, due to their non-peptide nature and oral bioavailability.Because of the relatively short half-life of elagolix, the actions of gonadotropin-releasing hormone (GnRH) are not fully blocked throughout the day. For this reason, gonadotropin and sex hormone levels are only partially suppressed, and the degree of suppression can be dose-dependently adjusted, as desired. Moreover, if elagolix is discontinued, its effects are rapidly reversible. Due to the suppression of estrogen levels by elagolix being incomplete, effects on bone mineral density are minimal, which is in contrast to first-generation GnRH inhibitors. Moreover, the incidence and severity of menopausal side effects such as hot flashes are also reduced relative to first-generation GnRH inhibitors.".
- Elagolix atcPrefix "H01".
- Elagolix atcSuffix "CC02".
- Elagolix casNumber "834153-87-6".
- Elagolix casSupplemental "832720-36-2 (sodium)".
- Elagolix iupacName "4-(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-dioxopyrimidin-1-yl]-1-phenylethyl]amino]butanoic acid".
- Elagolix pubchem "11250647".
- Elagolix thumbnail Elagolix_structure.png?width=300.
- Elagolix wikiPageExternalLink 800020238.
- Elagolix wikiPageExternalLink pipeline.html.
- Elagolix wikiPageExternalLink elagolix-gnrh-antagonist.
- Elagolix wikiPageID "48187627".
- Elagolix wikiPageLength "7030".
- Elagolix wikiPageOutDegree "34".
- Elagolix wikiPageRevisionID "685575534".
- Elagolix wikiPageWikiLink AbbVie_Inc..
- Elagolix wikiPageWikiLink Benign_prostatic_hyperplasia.
- Elagolix wikiPageWikiLink Bioavailability.
- Elagolix wikiPageWikiLink Bone_density.
- Elagolix wikiPageWikiLink Category:Amines.
- Elagolix wikiPageWikiLink Category:GnRH_antagonists.
- Elagolix wikiPageWikiLink Category:Organofluorides.
- Elagolix wikiPageWikiLink Category:Pyrimidines.
- Elagolix wikiPageWikiLink Clinical_trial.
- Elagolix wikiPageWikiLink Endometriosis.
- Elagolix wikiPageWikiLink Estrogen.
- Elagolix wikiPageWikiLink Gonadotropin.
- Elagolix wikiPageWikiLink Gonadotropin-releasing_hormone.
- Elagolix wikiPageWikiLink Gonadotropin-releasing_hormone_analogue.
- Elagolix wikiPageWikiLink Gonadotropin-releasing_hormone_antagonist.
- Elagolix wikiPageWikiLink Gonadotropin-releasing_hormone_receptor.
- Elagolix wikiPageWikiLink Half-life.
- Elagolix wikiPageWikiLink Hot_flash.
- Elagolix wikiPageWikiLink International_nonproprietary_name.
- Elagolix wikiPageWikiLink Menopause.
- Elagolix wikiPageWikiLink Mouth.
- Elagolix wikiPageWikiLink Neurocrine_Biosciences.
- Elagolix wikiPageWikiLink Oral_administration.
- Elagolix wikiPageWikiLink Phases_of_clinical_research.
- Elagolix wikiPageWikiLink Prostate_cancer.
- Elagolix wikiPageWikiLink Relugolix.
- Elagolix wikiPageWikiLink Sex_steroid.
- Elagolix wikiPageWikiLink Side_effect.
- Elagolix wikiPageWikiLink Small_molecule.
- Elagolix wikiPageWikiLink Sodium.
- Elagolix wikiPageWikiLink Sufugolix.
- Elagolix wikiPageWikiLink United_States_Adopted_Name.
- Elagolix wikiPageWikiLink Uterine_fibroid.
- Elagolix wikiPageWikiLink nowiki%3E.
- Elagolix wikiPageWikiLinkText "Elagolix".
- Elagolix wikiPageWikiLinkText "elagolix".
- Elagolix atcPrefix "H01".
- Elagolix atcSuffix "CC02".
- Elagolix c "32".
- Elagolix casNumber "834153".
- Elagolix casSupplemental "832720".
- Elagolix chemspiderid "9425680".
- Elagolix eliminationHalfLife "-22680.0".
- Elagolix f "5".
- Elagolix h "30".
- Elagolix inchi "InChI=1S/C32H30F5N3O5/c1-19-283040313917-22-2312-7-13-2433/h3-7,9-14,25,38H,8,15-18H2,1-2H3,/t25-/m0/s1".
- Elagolix inchikey "HEAUOKZIVMZVQL-VWLOTQADSA-N".
- Elagolix iupacName "4".
- Elagolix molecularWeight "631.589716".
- Elagolix n "3".
- Elagolix o "5".
- Elagolix pubchem "11250647".
- Elagolix routesOfAdministration Mouth.
- Elagolix smiles "CC1=CC4=CF".
- Elagolix synonyms "Elagolix sodium, NBI-56418, ABT-620".
- Elagolix wikiPageUsesTemplate Template:Drugbox.
- Elagolix wikiPageUsesTemplate Template:Genito-urinary-drug-stub.
- Elagolix wikiPageUsesTemplate Template:Gonadotropins_and_GnRH.
- Elagolix wikiPageUsesTemplate Template:Peptidergics.
- Elagolix wikiPageUsesTemplate Template:Reflist.
- Elagolix wikiPageUsesTemplate Template:Systemic-hormonal-drug-stub.
- Elagolix subject Category:Amines.
- Elagolix subject Category:GnRH_antagonists.
- Elagolix subject Category:Organofluorides.
- Elagolix subject Category:Pyrimidines.
- Elagolix type ChemicalSubstance.
- Elagolix type Drug.
- Elagolix type ChemicalObject.
- Elagolix type Thing.
- Elagolix type Q8386.
- Elagolix comment "Elagolix (INN, USAN) (former developmental code names NBI-56418, ABT-620) is a highly potent, selective, orally-active, short-duration, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (KD = 54 pM) that is under development for clinical use by Neurocrine Biosciences and AbbVie.".
- Elagolix label "Elagolix".
- Elagolix sameAs Q21098999.
- Elagolix sameAs Q21098999.
- Elagolix wasDerivedFrom Elagolix?oldid=685575534.
- Elagolix depiction Elagolix_structure.png.
- Elagolix isPrimaryTopicOf Elagolix.