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- Edelfosine abstract "Edelfosine (ET-18-O-CH3 ; 1-octadecyl-2-O-methyl-glycero-3-phosphocholine) is a synthetic alkyl-lysophospholipid (ALP). It has antineoplastic (anti-cancer) effects.Like all ALPs, it incorporates into the cell membrane and does not target the DNA. In many tumor cells, it causes selective apoptosis, sparing healthy cells. Edelfosine can activate the Fas/CD95 cell death receptor, can inhibit the MAPK/ERK mitogenic pathway and the Akt/protein kinase B (PKB) survival pathway. Aside from these plasma-level effects, edelfosine also affects gene expression by modulating the expression and activity of transcription factors.It has immune modulating properties. These characteristics cause edelfosine also to affect HIV, parasitic, and autoimmune diseases. It can complement classic anti-cancer drugs such as cisplatin.It can be administered orally, intraperitoneally (IP) and intravenously (IV).Edelfosine and other ALPs can be used for purging residual leukemic cells from bone marrow transplants.It is an analog of miltefosine and perifosine.".
- Edelfosine iupacName "2-Methoxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate".
- Edelfosine thumbnail Edelfosine.svg?width=300.
- Edelfosine wikiPageExternalLink blood-2006-04-016824v1.
- Edelfosine wikiPageExternalLink 2809.full.pdf.
- Edelfosine wikiPageExternalLink 704.full.
- Edelfosine wikiPageExternalLink 439.short.
- Edelfosine wikiPageExternalLink 135.
- Edelfosine wikiPageExternalLink jkx7m4110u70tu30.
- Edelfosine wikiPageID "31033582".
- Edelfosine wikiPageLength "13690".
- Edelfosine wikiPageOutDegree "24".
- Edelfosine wikiPageRevisionID "704878520".
- Edelfosine wikiPageWikiLink Alkyl-lysophospholipids.
- Edelfosine wikiPageWikiLink Apoptosis.
- Edelfosine wikiPageWikiLink Bone_marrow.
- Edelfosine wikiPageWikiLink Breast_cancer.
- Edelfosine wikiPageWikiLink Category:Phospholipids.
- Edelfosine wikiPageWikiLink Category:Quaternary_ammonium_compounds.
- Edelfosine wikiPageWikiLink Category:Zwitterions.
- Edelfosine wikiPageWikiLink Cell_membrane.
- Edelfosine wikiPageWikiLink Chemotherapy.
- Edelfosine wikiPageWikiLink Cisplatin.
- Edelfosine wikiPageWikiLink DNA.
- Edelfosine wikiPageWikiLink Fas_receptor.
- Edelfosine wikiPageWikiLink HIV.
- Edelfosine wikiPageWikiLink Leukemia.
- Edelfosine wikiPageWikiLink Lysophosphatidylcholine.
- Edelfosine wikiPageWikiLink ERK_pathway.
- Edelfosine wikiPageWikiLink Macrophage.
- Edelfosine wikiPageWikiLink Miltefosine.
- Edelfosine wikiPageWikiLink Multiple_myeloma.
- Edelfosine wikiPageWikiLink Non-small-cell_lung_carcinoma.
- Edelfosine wikiPageWikiLink Perifosine.
- Edelfosine wikiPageWikiLink Protein_kinase_B.
- Edelfosine wikiPageWikiLinkText "Edelfosine".
- Edelfosine wikiPageWikiLinkText "edelfosine".
- Edelfosine imagefile "Edelfosine.svg".
- Edelfosine imagesize "250".
- Edelfosine iupacname "2".
- Edelfosine othernames "ET-18-O-CH3 ; 1-Ooctadecyl-2-O-methyl-glycero-3-phosphocholine".
- Edelfosine verifiedfields "changed".
- Edelfosine verifiedrevid "457477026".
- Edelfosine watchedfields "changed".
- Edelfosine wikiPageUsesTemplate Template:Cascite.
- Edelfosine wikiPageUsesTemplate Template:Chembox.
- Edelfosine wikiPageUsesTemplate Template:Chembox_Hazards.
- Edelfosine wikiPageUsesTemplate Template:Chembox_Identifiers.
- Edelfosine wikiPageUsesTemplate Template:Chembox_Pharmacology.
- Edelfosine wikiPageUsesTemplate Template:Chembox_Properties.
- Edelfosine wikiPageUsesTemplate Template:Chemspidercite.
- Edelfosine wikiPageUsesTemplate Template:Ebicite.
- Edelfosine wikiPageUsesTemplate Template:Fdacite.
- Edelfosine wikiPageUsesTemplate Template:Reflist.
- Edelfosine wikiPageUsesTemplate Template:Stdinchicite.
- Edelfosine subject Category:Phospholipids.
- Edelfosine subject Category:Quaternary_ammonium_compounds.
- Edelfosine subject Category:Zwitterions.
- Edelfosine type ChemicalCompound.
- Edelfosine type ChemicalSubstance.
- Edelfosine type Lipid.
- Edelfosine type Chemical.
- Edelfosine type Lipid.
- Edelfosine type Organophosphate.
- Edelfosine type Organophosphate.
- Edelfosine type ChemicalObject.
- Edelfosine type Thing.
- Edelfosine type Q11173.
- Edelfosine comment "Edelfosine (ET-18-O-CH3 ; 1-octadecyl-2-O-methyl-glycero-3-phosphocholine) is a synthetic alkyl-lysophospholipid (ALP). It has antineoplastic (anti-cancer) effects.Like all ALPs, it incorporates into the cell membrane and does not target the DNA. In many tumor cells, it causes selective apoptosis, sparing healthy cells. Edelfosine can activate the Fas/CD95 cell death receptor, can inhibit the MAPK/ERK mitogenic pathway and the Akt/protein kinase B (PKB) survival pathway.".
- Edelfosine label "Edelfosine".
- Edelfosine sameAs Q3579094.
- Edelfosine sameAs Edelfosin.
- Edelfosine sameAs ادلفوزین.
- Edelfosine sameAs Édelfosine.
- Edelfosine sameAs m.0ggbq1y.
- Edelfosine sameAs Edelfozin.
- Edelfosine sameAs Edelfozin.
- Edelfosine sameAs Q3579094.
- Edelfosine wasDerivedFrom Edelfosine?oldid=704878520.
- Edelfosine depiction Edelfosine.svg.
- Edelfosine isPrimaryTopicOf Edelfosine.