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- Ectopic_recombination abstract "Ectopic recombination is an aberrant form of recombination in which crossing over occurs at non-homologous, rather than along homologous, loci. Such recombination often results in dramatic chromosomal rearrangement, which is generally deleterious. Some research, however, has suggested that ectopic recombination can result in mutated chromosomes that benefit the organism. Ectopic recombination can occur during both meiosis and mitosis, although it is more likely to occur during meiosis. It occurs relatively frequently—in at least one yeast species (Saccharomyces cerevisiae) the frequency of ectopic recombination is roughly on par with that of allelic (or traditional) recombination. Another factor affecting the frequency of this cross-over event is the zygosity of the alleles in the loci of interest. If the alleles are heterozygous, then ectopic recombination is relatively likely to occur, whereas if the alleles are homozygous, they will almost certainly undergo allelic recombination. Ectopic recombination does not require loci involved to be close to one another; it can occur between loci that are widely separated on a single chromosome, and has even been known to occur across chromosomes. Neither does it require high levels of homology between sequences—the lower limit required for it to occur has been estimated at as low as 2.2 kb of homologous stretches of DNA nucleotides. Additionally, the number of available ectopic sites of a gene does not increase the probability of recombination, but it instead relies more heavily on the activation of the loci to become a recipient of cross-over that will be involved.The role of transposable elements in ectopic recombination is an area of active inquiry. Transposable elements—repetitious sequences of DNA that can insert themselves into any part of the genome—can encourage ectopic recombination at repeated homologous sequences of nucleotides. However, according to one proposed model, ectopic recombination might serve as an inhibitor of high transposable element copy numbers. The frequency of ectopic recombination of transposable elements has been linked to both higher copy numbers of transposable elements and the longer lengths of those elements. Since ectopic recombination is generally deleterious, anything that increases its odds of occurring is selected against, including the aforementioned higher copy numbers and longer lengths. This model, however, can only be applied to single families of transposable elements in the genome, as the probability of ectopic recombination occurring in one TE family is independent of it occurring in another. It follows that transposable elements that are shorter, transpose themselves less often, and have mutation rates high enough to disrupt the homology between transposable element sequences sufficiently to prevent ectopic recombination from occurring are selected for.".
- Ectopic_recombination wikiPageID "24039902".
- Ectopic_recombination wikiPageLength "4721".
- Ectopic_recombination wikiPageOutDegree "13".
- Ectopic_recombination wikiPageRevisionID "578760205".
- Ectopic_recombination wikiPageWikiLink Category:Cellular_processes.
- Ectopic_recombination wikiPageWikiLink Category:Molecular_genetics.
- Ectopic_recombination wikiPageWikiLink Chromosomal_crossover.
- Ectopic_recombination wikiPageWikiLink Chromosome.
- Ectopic_recombination wikiPageWikiLink Genetic_recombination.
- Ectopic_recombination wikiPageWikiLink Genome.
- Ectopic_recombination wikiPageWikiLink Locus_(genetics).
- Ectopic_recombination wikiPageWikiLink Meiosis.
- Ectopic_recombination wikiPageWikiLink Mitosis.
- Ectopic_recombination wikiPageWikiLink Nucleotide.
- Ectopic_recombination wikiPageWikiLink Saccharomyces_cerevisiae.
- Ectopic_recombination wikiPageWikiLink Transposable_element.
- Ectopic_recombination wikiPageWikiLink Zygosity.
- Ectopic_recombination wikiPageWikiLinkText "Ectopic recombination".
- Ectopic_recombination wikiPageWikiLinkText "ectopic recombination".
- Ectopic_recombination wikiPageWikiLinkText "ectopically".
- Ectopic_recombination wikiPageUsesTemplate Template:Reflist.
- Ectopic_recombination subject Category:Cellular_processes.
- Ectopic_recombination subject Category:Molecular_genetics.
- Ectopic_recombination hypernym Form.
- Ectopic_recombination type Process.
- Ectopic_recombination comment "Ectopic recombination is an aberrant form of recombination in which crossing over occurs at non-homologous, rather than along homologous, loci. Such recombination often results in dramatic chromosomal rearrangement, which is generally deleterious. Some research, however, has suggested that ectopic recombination can result in mutated chromosomes that benefit the organism. Ectopic recombination can occur during both meiosis and mitosis, although it is more likely to occur during meiosis.".
- Ectopic_recombination label "Ectopic recombination".
- Ectopic_recombination sameAs Q5334294.
- Ectopic_recombination sameAs m.07kj6hz.
- Ectopic_recombination sameAs Q5334294.
- Ectopic_recombination wasDerivedFrom Ectopic_recombination?oldid=578760205.
- Ectopic_recombination isPrimaryTopicOf Ectopic_recombination.