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- Ecotin abstract "In molecular biology, ecotin is a protease inhibitor which belongs to MEROPS inhibitor family I11, clan IN. Ecotins are dimeric periplasmic proteins from Escherichia coli and related Gram-negative bacteria that have been shown to be potent inhibitors of many trypsin-fold serine proteases of widely varying substrate specificity, which belong to MEROPS peptidase family S1. Phylogenetic analysis suggested that ecotin has an exogenous target, possibly neutrophil elastase. Ecotin from E. coli, Yersinia pestis, and Pseudomonas aeruginosa, all species that encounter the mammalian immune system, inhibit neutrophil elastase strongly while ecotin from the plant pathogen Pantoea citrea inhibits neutrophil elastase 1000-fold less potently. Ecotins all potently inhibit pancreatic digestive peptidases trypsin and chymotrypsin, while showing more variable inhibition of the blood peptidases Factor Xa, thrombin, and urokinase-type plasminogen activator.".
- Ecotin symbol "Ecotin".
- Ecotin thumbnail PDB_1ifg_EBI.jpg?width=300.
- Ecotin wikiPageExternalLink famsum?family=S1.
- Ecotin wikiPageExternalLink pepsum?id=I11.001;type=I.
- Ecotin wikiPageID "32646106".
- Ecotin wikiPageLength "2544".
- Ecotin wikiPageOutDegree "30".
- Ecotin wikiPageRevisionID "591143597".
- Ecotin wikiPageWikiLink Blood.
- Ecotin wikiPageWikiLink Category:Protein_families.
- Ecotin wikiPageWikiLink Chymotrypsin.
- Ecotin wikiPageWikiLink Enzyme_inhibitor.
- Ecotin wikiPageWikiLink Escherichia_coli.
- Ecotin wikiPageWikiLink Exogeny.
- Ecotin wikiPageWikiLink Factor_X.
- Ecotin wikiPageWikiLink Gram-negative_bacteria.
- Ecotin wikiPageWikiLink Immune_system.
- Ecotin wikiPageWikiLink MEROPS.
- Ecotin wikiPageWikiLink Mammal.
- Ecotin wikiPageWikiLink Neutrophil_elastase.
- Ecotin wikiPageWikiLink Pancreas.
- Ecotin wikiPageWikiLink Pathogen.
- Ecotin wikiPageWikiLink Periplasm.
- Ecotin wikiPageWikiLink Phylogenetics.
- Ecotin wikiPageWikiLink Plant.
- Ecotin wikiPageWikiLink Plasminogen_activator.
- Ecotin wikiPageWikiLink Protease_inhibitor_(biology).
- Ecotin wikiPageWikiLink Protein.
- Ecotin wikiPageWikiLink Protein_dimer.
- Ecotin wikiPageWikiLink Pseudomonas_aeruginosa.
- Ecotin wikiPageWikiLink Serine_protease.
- Ecotin wikiPageWikiLink Species.
- Ecotin wikiPageWikiLink Thrombin.
- Ecotin wikiPageWikiLink Trypsin.
- Ecotin wikiPageWikiLink Urokinase.
- Ecotin wikiPageWikiLink Yersinia_pestis.
- Ecotin caption "crystal structure of a monomeric form of general protease inhibitor, ecotin in absence of a protease".
- Ecotin interpro "IPR005658".
- Ecotin name "Ecotin".
- Ecotin pfam "PF03974".
- Ecotin scop "1".
- Ecotin symbol "Ecotin".
- Ecotin wikiPageUsesTemplate Template:Infobox_protein_family.
- Ecotin wikiPageUsesTemplate Template:InterPro_content.
- Ecotin wikiPageUsesTemplate Template:Orphan.
- Ecotin wikiPageUsesTemplate Template:Reflist.
- Ecotin subject Category:Protein_families.
- Ecotin hypernym Inhibitor.
- Ecotin type Biomolecule.
- Ecotin type Drug.
- Ecotin type Protein.
- Ecotin type Chemical.
- Ecotin type Thing.
- Ecotin type Q206229.
- Ecotin type Q8054.
- Ecotin comment "In molecular biology, ecotin is a protease inhibitor which belongs to MEROPS inhibitor family I11, clan IN. Ecotins are dimeric periplasmic proteins from Escherichia coli and related Gram-negative bacteria that have been shown to be potent inhibitors of many trypsin-fold serine proteases of widely varying substrate specificity, which belong to MEROPS peptidase family S1. Phylogenetic analysis suggested that ecotin has an exogenous target, possibly neutrophil elastase. Ecotin from E.".
- Ecotin label "Ecotin".
- Ecotin sameAs Q5333890.
- Ecotin sameAs m.0h3ppl4.
- Ecotin sameAs Q5333890.
- Ecotin wasDerivedFrom Ecotin?oldid=591143597.
- Ecotin depiction PDB_1ifg_EBI.jpg.
- Ecotin isPrimaryTopicOf Ecotin.