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- Ecdysteroid-phosphate_phosphatase abstract "Ecdysteroid-phosphate Phosphatase is the first structure of a steroid phosphate phosphotase containing alpha beta folds common to members of the two histidine (2H)-Phosphatase superfamily with strong homology to the Suppressor of T-cell receptor signaling-1 (Sts-1 PGM) protein. The putative EPPase PGM active site contains signature residues shared by 2H-phosphatase enzymes, including a conserved histidine (His80) that acts as a nucleophile during catalysis. The physiological substrate ecdysone 22-phosphate was modeled in a hydrophobic cavity close to the phosphate-binding site. EPPase PGM shows limited substrate specificity with an ability to hydrolyze steroid phosphates, the phospho-tyrosine (pTyr) substrate analogue para-nitrophenylphosphate ( pNPP) and pTyr-containing peptides and proteins. It has been shown that new protein tyrosine phosphatase (PTP) activity for EPPase. Also, EPPase and its closest homologues can be grouped into a distinct subfamily in the large 2H-Phosphatase superfamily of proteins.".
- Ecdysteroid-phosphate_phosphatase thumbnail EcdysonePhosphatePhosphatase.jpg?width=300.
- Ecdysteroid-phosphate_phosphatase wikiPageExternalLink explore.do?structureId=3C7T.
- Ecdysteroid-phosphate_phosphatase wikiPageExternalLink mmdbsrv.cgi?uid=70358.
- Ecdysteroid-phosphate_phosphatase wikiPageExternalLink remediatedSequence.do?structureId=3C7T.
- Ecdysteroid-phosphate_phosphatase wikiPageID "29824046".
- Ecdysteroid-phosphate_phosphatase wikiPageLength "2533".
- Ecdysteroid-phosphate_phosphatase wikiPageOutDegree "19".
- Ecdysteroid-phosphate_phosphatase wikiPageRevisionID "701365542".
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink beta_hydrolase_fold.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Binding_site.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Catalysis.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Category:EC_3.1.3.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Category:Hydrolases.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Category:Metabolic_pathways.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Category:Posttranslational_modification.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Category:Steroids.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Chemical_specificity.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Histidine.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Homology_(chemistry).
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Nucleophile.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Phosphatase.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Plasmid.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Residue_(chemistry).
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink Structural_analog.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink X-ray_scattering_techniques.
- Ecdysteroid-phosphate_phosphatase wikiPageWikiLink File:EcdysonePhosphatePhosphatase.jpg.
- Ecdysteroid-phosphate_phosphatase wikiPageUsesTemplate Template:Cite_web.
- Ecdysteroid-phosphate_phosphatase wikiPageUsesTemplate Template:Enzymes.
- Ecdysteroid-phosphate_phosphatase wikiPageUsesTemplate Template:Esterases.
- Ecdysteroid-phosphate_phosphatase wikiPageUsesTemplate Template:Orphan.
- Ecdysteroid-phosphate_phosphatase wikiPageUsesTemplate Template:Portal_bar.
- Ecdysteroid-phosphate_phosphatase subject Category:EC_3.1.3.
- Ecdysteroid-phosphate_phosphatase subject Category:Hydrolases.
- Ecdysteroid-phosphate_phosphatase subject Category:Metabolic_pathways.
- Ecdysteroid-phosphate_phosphatase subject Category:Posttranslational_modification.
- Ecdysteroid-phosphate_phosphatase subject Category:Steroids.
- Ecdysteroid-phosphate_phosphatase hypernym Structure.
- Ecdysteroid-phosphate_phosphatase type Building.
- Ecdysteroid-phosphate_phosphatase type Lipid.
- Ecdysteroid-phosphate_phosphatase type Lipid.
- Ecdysteroid-phosphate_phosphatase type Pathway.
- Ecdysteroid-phosphate_phosphatase type Steroid.
- Ecdysteroid-phosphate_phosphatase type Terpene.
- Ecdysteroid-phosphate_phosphatase comment "Ecdysteroid-phosphate Phosphatase is the first structure of a steroid phosphate phosphotase containing alpha beta folds common to members of the two histidine (2H)-Phosphatase superfamily with strong homology to the Suppressor of T-cell receptor signaling-1 (Sts-1 PGM) protein. The putative EPPase PGM active site contains signature residues shared by 2H-phosphatase enzymes, including a conserved histidine (His80) that acts as a nucleophile during catalysis.".
- Ecdysteroid-phosphate_phosphatase label "Ecdysteroid-phosphate phosphatase".
- Ecdysteroid-phosphate_phosphatase sameAs Q5332336.
- Ecdysteroid-phosphate_phosphatase sameAs m.0fq15y_.
- Ecdysteroid-phosphate_phosphatase sameAs Q5332336.
- Ecdysteroid-phosphate_phosphatase wasDerivedFrom Ecdysteroid-phosphate_phosphatase?oldid=701365542.
- Ecdysteroid-phosphate_phosphatase depiction EcdysonePhosphatePhosphatase.jpg.
- Ecdysteroid-phosphate_phosphatase isPrimaryTopicOf Ecdysteroid-phosphate_phosphatase.