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- Ecarin_clotting_time abstract "Ecarin clotting time (ECT) is a laboratory test used to monitor anticoagulation during treatment with hirudin, an anticoagulant medication which was originally isolated from leech saliva. Ecarin, the primary reagent in this assay, is derived from the venom of the saw-scaled viper, Echis carinatus. In the clinical assay, a known quantity of ecarin is added to the plasma of a patient treated with hirudin. Ecarin activates prothrombin through a specific proteolytic cleavage, which produces meizothrombin, a prothrombin-thrombin intermediate which retains the full molecular weight of prothrombin, but possesses a low level of procoagulant enzymatic activity. Crucially, this activity is inhibited by hirudin and other direct thrombin inhibitors, but not by heparin. The ECT is also unaffected by prior treatment with coumadin or the presence of phospholipid-dependent anticoagulants, such as lupus anticoagulant. Thus, the ECT is prolonged in a specific and linear fashion with increasing concentrations of hirudin. An enhancement of the ECT is the ecarin chromogenic assay (ECA) in which diluted sample is mixed with an excess of purified prothrombin and the generated meizothrombin is measured with a specific chromogenic substrate. This assay shows no interference from prothrombin or fibrinogen in the sample and is suitable for the measurement of all direct thrombin inhibitors Lange U, Nowak G, Bucha E. Ecarin chromogenic assay—a new method for quantitative determination of direct thrombin inhibitors like hirudin. Pathophysiol Haemost Thromb. 2003 Jul-2004 Aug;33(4):184-91.".
- Ecarin_clotting_time thumbnail Echis_carinatus_sal.jpg?width=300.
- Ecarin_clotting_time wikiPageID "11598554".
- Ecarin_clotting_time wikiPageLength "2618".
- Ecarin_clotting_time wikiPageOutDegree "12".
- Ecarin_clotting_time wikiPageRevisionID "530160049".
- Ecarin_clotting_time wikiPageWikiLink Anticoagulant.
- Ecarin_clotting_time wikiPageWikiLink Category:Blood_tests.
- Ecarin_clotting_time wikiPageWikiLink Ecarin.
- Ecarin_clotting_time wikiPageWikiLink Echis_carinatus.
- Ecarin_clotting_time wikiPageWikiLink Heparin.
- Ecarin_clotting_time wikiPageWikiLink Hirudin.
- Ecarin_clotting_time wikiPageWikiLink Leech.
- Ecarin_clotting_time wikiPageWikiLink Lupus_anticoagulant.
- Ecarin_clotting_time wikiPageWikiLink Pharmaceutical_drug.
- Ecarin_clotting_time wikiPageWikiLink Thrombin.
- Ecarin_clotting_time wikiPageWikiLink Warfarin.
- Ecarin_clotting_time wikiPageWikiLink File:Echis_carinatus_sal.jpg.
- Ecarin_clotting_time wikiPageWikiLinkText "Ecarin clotting time".
- Ecarin_clotting_time wikiPageWikiLinkText "ecarin clotting time".
- Ecarin_clotting_time wikiPageUsesTemplate Template:Cite_journal.
- Ecarin_clotting_time wikiPageUsesTemplate Template:Immunology-stub.
- Ecarin_clotting_time wikiPageUsesTemplate Template:Myeloid_blood_tests.
- Ecarin_clotting_time wikiPageUsesTemplate Template:Reflist.
- Ecarin_clotting_time subject Category:Blood_tests.
- Ecarin_clotting_time hypernym Test.
- Ecarin_clotting_time type Cricketer.
- Ecarin_clotting_time comment "Ecarin clotting time (ECT) is a laboratory test used to monitor anticoagulation during treatment with hirudin, an anticoagulant medication which was originally isolated from leech saliva. Ecarin, the primary reagent in this assay, is derived from the venom of the saw-scaled viper, Echis carinatus. In the clinical assay, a known quantity of ecarin is added to the plasma of a patient treated with hirudin.".
- Ecarin_clotting_time label "Ecarin clotting time".
- Ecarin_clotting_time sameAs Q5332144.
- Ecarin_clotting_time sameAs Ecarin_Clotting_Time.
- Ecarin_clotting_time sameAs m.02rl2gh.
- Ecarin_clotting_time sameAs Q5332144.
- Ecarin_clotting_time wasDerivedFrom Ecarin_clotting_time?oldid=530160049.
- Ecarin_clotting_time depiction Echis_carinatus_sal.jpg.
- Ecarin_clotting_time isPrimaryTopicOf Ecarin_clotting_time.