Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/EZH2> ?p ?o }
- EZH2 abstract "Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in DNA methylation and, ultimately, transcriptional repression. EZH2 catalyzes the addition of methyl groups to histone H3 at lysine 27, by using the cofactor S-adenosyl-L-methionine. Methylation activity of EZH2 facilitates heterochromatin formation thereby silences gene function. Remodeling of chromosomal heterochromatin by EZH2 is also required during cell mitosis.EZH2 is the functional enzymatic component of the polycomb repressive complex 2 (PRC2), which is responsible for healthy embryonic development through the epigenetic maintenance of genes responsible for regulating development and differentiation. EZH2 is responsible for the methylation activity of PRC2, and the complex also contains proteins required for optimal function (EED, SUZ12, JARID2, AEBP2, RbAp46/48, and PCL).Mutation or over-expression of EZH2 has been linked to many to forms of cancer. EZH2 inhibits genes responsible for suppressing tumor development, and blocking EZH2 activity may slow tumor growth. EZH2 has been targeted for inhibition because it is upregulated in multiple cancers including, but not limited to, breast, prostate, melanoma, and bladder cancer. Mutations in the EZH2 gene are also associated with Weaver syndrome, a rare congenital disorder, and EZH2 is involved in causing neurodegenerative symptoms in the nervous system disorder, ataxia telangiectasia.".
- EZH2 entrezgene "2146".
- EZH2 wikiPageID "14134041".
- EZH2 wikiPageLength "43717".
- EZH2 wikiPageOutDegree "142".
- EZH2 wikiPageRevisionID "705280843".
- EZH2 wikiPageWikiLink 3-Deazaneplanocin_A.
- EZH2 wikiPageWikiLink AEBP2.
- EZH2 wikiPageWikiLink Acetylation.
- EZH2 wikiPageWikiLink Acid_dissociation_constant.
- EZH2 wikiPageWikiLink Active_site.
- EZH2 wikiPageWikiLink Alternative_splicing.
- EZH2 wikiPageWikiLink Ammonium.
- EZH2 wikiPageWikiLink Apoptosis.
- EZH2 wikiPageWikiLink Ataxia_telangiectasia.
- EZH2 wikiPageWikiLink B_cell.
- EZH2 wikiPageWikiLink Category:EC_2.1.1.
- EZH2 wikiPageWikiLink Cell_division.
- EZH2 wikiPageWikiLink Cellular_differentiation.
- EZH2 wikiPageWikiLink Chromatin.
- EZH2 wikiPageWikiLink Chromosome_segregation.
- EZH2 wikiPageWikiLink Cofactor_(biochemistry).
- EZH2 wikiPageWikiLink Congenital_disorder.
- EZH2 wikiPageWikiLink Cyclin_D1.
- EZH2 wikiPageWikiLink DNA_methylation.
- EZH2 wikiPageWikiLink DNA_methyltransferase.
- EZH2 wikiPageWikiLink Deprotonation.
- EZH2 wikiPageWikiLink Drosophila_melanogaster.
- EZH2 wikiPageWikiLink EED.
- EZH2 wikiPageWikiLink EZH1.
- EZH2 wikiPageWikiLink Embryogenesis.
- EZH2 wikiPageWikiLink Enzyme.
- EZH2 wikiPageWikiLink Epidermal_growth_factor_receptor.
- EZH2 wikiPageWikiLink Epigenetics.
- EZH2 wikiPageWikiLink Etoposide.
- EZH2 wikiPageWikiLink Evolution.
- EZH2 wikiPageWikiLink Exon.
- EZH2 wikiPageWikiLink Gene.
- EZH2 wikiPageWikiLink GlaxoSmithKline.
- EZH2 wikiPageWikiLink HOXA9.
- EZH2 wikiPageWikiLink HOXC8.
- EZH2 wikiPageWikiLink Haematopoiesis.
- EZH2 wikiPageWikiLink Heterochromatin.
- EZH2 wikiPageWikiLink Histidine.
- EZH2 wikiPageWikiLink Histone.
- EZH2 wikiPageWikiLink Histone_H3.
- EZH2 wikiPageWikiLink Histone_code.
- EZH2 wikiPageWikiLink Histone_methyltransferase.
- EZH2 wikiPageWikiLink Hypertelorism.
- EZH2 wikiPageWikiLink JARID2.
- EZH2 wikiPageWikiLink Kidney_cancer.
- EZH2 wikiPageWikiLink Lymphoma.
- EZH2 wikiPageWikiLink Lysine.
- EZH2 wikiPageWikiLink MYT1.
- EZH2 wikiPageWikiLink Macrocephaly.
- EZH2 wikiPageWikiLink Malignancy.
- EZH2 wikiPageWikiLink Melanoma.
- EZH2 wikiPageWikiLink Methyl_group.
- EZH2 wikiPageWikiLink Methylation.
- EZH2 wikiPageWikiLink Methyltransferase.
- EZH2 wikiPageWikiLink Myc.
- EZH2 wikiPageWikiLink Myelodysplastic_syndrome.
- EZH2 wikiPageWikiLink NF-κB.
- EZH2 wikiPageWikiLink Neoplasm.
- EZH2 wikiPageWikiLink Neurodegeneration.
- EZH2 wikiPageWikiLink Novartis.
- EZH2 wikiPageWikiLink Nuclear_localization_sequence.
- EZH2 wikiPageWikiLink Nucleophile.
- EZH2 wikiPageWikiLink PHF1.
- EZH2 wikiPageWikiLink PRC1.
- EZH2 wikiPageWikiLink PRC2.
- EZH2 wikiPageWikiLink Phenylalanine.
- EZH2 wikiPageWikiLink Phosphorylation.
- EZH2 wikiPageWikiLink Prostate_cancer.
- EZH2 wikiPageWikiLink Protein_isoform.
- EZH2 wikiPageWikiLink Protein_subunit.
- EZH2 wikiPageWikiLink RBBP4.
- EZH2 wikiPageWikiLink Retinoblastoma_protein.
- EZH2 wikiPageWikiLink Retinoic_acid.
- EZH2 wikiPageWikiLink S-Adenosyl_methionine.
- EZH2 wikiPageWikiLink S-adenosylmethionine_synthetase_enzyme.
- EZH2 wikiPageWikiLink SET_domain.
- EZH2 wikiPageWikiLink SMARCA4.
- EZH2 wikiPageWikiLink SN2_reaction.
- EZH2 wikiPageWikiLink SUZ12.
- EZH2 wikiPageWikiLink Serine.
- EZH2 wikiPageWikiLink Substrate_(chemistry).
- EZH2 wikiPageWikiLink T_cell.
- EZH2 wikiPageWikiLink Threonine.
- EZH2 wikiPageWikiLink Topoisomerase.
- EZH2 wikiPageWikiLink Transcription_(genetics).
- EZH2 wikiPageWikiLink Transcriptional_regulation.
- EZH2 wikiPageWikiLink Tyrosine.
- EZH2 wikiPageWikiLink Ubiquitin.
- EZH2 wikiPageWikiLink Uterine_cancer.
- EZH2 wikiPageWikiLink Weaver_syndrome.
- EZH2 wikiPageWikiLink Wild_type.
- EZH2 wikiPageWikiLink Wnt_signaling_pathway.
- EZH2 wikiPageWikiLink X-inactivation.
- EZH2 wikiPageWikiLink X_chromosome.