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- ERCC4 abstract "ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.The nuclease enzyme ERCC1-XPF cuts specific structures of DNA. Many aspects of these two gene products are described together here because they are partners during DNA repair. The ERCC1-XPF nuclease is an essential activity in the pathway of DNA nucleotide excision repair (NER). The ERCC1-XPF nuclease also functions in pathways to repair double-strand breaks in DNA, and in the repair of “crosslink” damage that harmfully links the two DNA strands.Cells with disabling mutations in ERCC4 are more sensitive than normal to particular DNA damaging agents, including ultraviolet radiation and to chemicals that cause crosslinking between DNA strands. Genetically engineered mice with disabling mutations in ERCC4 also have defects in DNA repair, accompanied by metabolic stress-induced changes in physiology that result in premature aging. Complete deletion of ERCC4 is incompatible with viability of mice, and no human individuals have been found with complete (homozygous) deletion of ERCC4. Rare individuals in the human population harbor inherited mutations that impair the function of ERCC4. When the normal genes are absent, these mutations can lead to human syndromes, including xeroderma pigmentosum, Cockayne syndrome and Fanconi anemia.ERCC1 and ERCC4 are the human gene names and Ercc1 and Ercc4 are the analogous mammalian gene names. Similar genes with similar functions are found in all eukaryotic organisms.".
- ERCC4 entrezgene "2072".
- ERCC4 thumbnail Fig_1_XPF_Wikigene.png?width=300.
- ERCC4 wikiPageExternalLink br.fcgi?book=gene&part=xp.
- ERCC4 wikiPageID "14760958".
- ERCC4 wikiPageLength "27088".
- ERCC4 wikiPageOutDegree "37".
- ERCC4 wikiPageRevisionID "696883381".
- ERCC4 wikiPageWikiLink Category:Human_proteins.
- ERCC4 wikiPageWikiLink Cell_nucleus.
- ERCC4 wikiPageWikiLink Cockayne_syndrome.
- ERCC4 wikiPageWikiLink Counterstain.
- ERCC4 wikiPageWikiLink DNA_repair.
- ERCC4 wikiPageWikiLink ERCC1.
- ERCC4 wikiPageWikiLink Epigenetics.
- ERCC4 wikiPageWikiLink Fanconi_anemia.
- ERCC4 wikiPageWikiLink Gene.
- ERCC4 wikiPageWikiLink Haematoxylin.
- ERCC4 wikiPageWikiLink Homology_(biology).
- ERCC4 wikiPageWikiLink Intestinal_epithelium.
- ERCC4 wikiPageWikiLink Intestinal_gland.
- ERCC4 wikiPageWikiLink Invagination.
- ERCC4 wikiPageWikiLink Knockout_mouse.
- ERCC4 wikiPageWikiLink Lamina_propria.
- ERCC4 wikiPageWikiLink Large_intestine.
- ERCC4 wikiPageWikiLink Lumen_(anatomy).
- ERCC4 wikiPageWikiLink Neoplasm.
- ERCC4 wikiPageWikiLink Nuclease.
- ERCC4 wikiPageWikiLink Nucleotide_excision_repair.
- ERCC4 wikiPageWikiLink Protein.
- ERCC4 wikiPageWikiLink Recombinant_DNA.
- ERCC4 wikiPageWikiLink Stem_cell.
- ERCC4 wikiPageWikiLink Ultraviolet.
- ERCC4 wikiPageWikiLink Xeroderma_pigmentosum.
- ERCC4 wikiPageWikiLink File:Fig_1_XPF_Wikigene.png.
- ERCC4 wikiPageWikiLink File:Fig_2_XPF_Substrate_Wikigene.png.
- ERCC4 wikiPageWikiLink File:Sequential_sections_of_a_colon_crypt_showing_normal_high_expression_of_PMS2_(A),_ERCC1_(B)_and_ERCC4_(C).jpg.tif.
- ERCC4 wikiPageWikiLink File:Sequential_sections_of_colon_epithelium_near_a_cancer_showing_reduced_or_absent_expression_of_PMS2_(A),_ERCC1_(B)_and_ERCC4_(C).tif.
- ERCC4 wikiPageWikiLinkText "ERCC4".
- ERCC4 wikiPageWikiLinkText "XPF".
- ERCC4 wikiPageUsesTemplate Template:DNA_repair.
- ERCC4 wikiPageUsesTemplate Template:PBB.
- ERCC4 wikiPageUsesTemplate Template:PDB_Gallery.
- ERCC4 wikiPageUsesTemplate Template:Reflist.
- ERCC4 subject Category:Human_proteins.
- ERCC4 hypernym Protein.
- ERCC4 type Biomolecule.
- ERCC4 type Protein.
- ERCC4 type Thing.
- ERCC4 type Q206229.
- ERCC4 type Q8054.
- ERCC4 comment "ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination.The nuclease enzyme ERCC1-XPF cuts specific structures of DNA. Many aspects of these two gene products are described together here because they are partners during DNA repair.".
- ERCC4 label "ERCC4".
- ERCC4 sameAs Q17917469.
- ERCC4 sameAs m.03gx157.
- ERCC4 sameAs Q17917469.
- ERCC4 wasDerivedFrom ERCC4?oldid=696883381.
- ERCC4 depiction Fig_1_XPF_Wikigene.png.
- ERCC4 isPrimaryTopicOf ERCC4.