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- EPI-001 abstract "EPI-001 is a novel experimental non-steroidal antiandrogen that is under investigation for the treatment of prostate cancer. The drug is being developed by the pharmaceutical company ESSA Pharma Inc (Vancouver, Canada) for the treatment of castration-resistant prostate cancer (CRPC) and is currently in pre-clinical development.EPI-001 is an antagonist of the androgen receptor (AR) that acts by binding covalently to the N-terminal domain (NTD) of the AR and blocking protein-protein interactions required for transcriptional activity of the AR and its splice variants (IC50 for inhibition of AR NTD transactivation ≈ 6 µM). This is different from all currently-used antiandrogens, which, conversely, bind to the C-terminal ligand-binding domain (LBD) of the AR and competitively block binding and activation of the receptor by androgens. Due to its unique mechanism of action, EPI-001 may prove to be effective in the treatment of advanced prostate cancer resistant to conventional antiandrogens such as enzalutamide.As of 2016, EPI-001's successor, EPI-506, is under clinical investigation in a phase I/II study.".
- EPI-001 iupacName "3-(4-{2-[4-(3-Chloro-2-hydroxypropoxy)phenyl]-2-propanyl}phenoxy)-1,2-propanediol".
- EPI-001 pubchem "4166922".
- EPI-001 thumbnail EPI-001.svg?width=300.
- EPI-001 wikiPageID "38508096".
- EPI-001 wikiPageLength "11715".
- EPI-001 wikiPageOutDegree "46".
- EPI-001 wikiPageRevisionID "707247508".
- EPI-001 wikiPageWikiLink Abiraterone_acetate.
- EPI-001 wikiPageWikiLink Alternative_splicing.
- EPI-001 wikiPageWikiLink Androgen.
- EPI-001 wikiPageWikiLink Androgen_receptor.
- EPI-001 wikiPageWikiLink Androgen_response_element.
- EPI-001 wikiPageWikiLink Antiandrogen.
- EPI-001 wikiPageWikiLink Apalutamide.
- EPI-001 wikiPageWikiLink Bisphenol.
- EPI-001 wikiPageWikiLink Bisphenol_A_diglycidyl_ether.
- EPI-001 wikiPageWikiLink C-terminus.
- EPI-001 wikiPageWikiLink CREB-binding_protein.
- EPI-001 wikiPageWikiLink Category:Alkylating_agents.
- EPI-001 wikiPageWikiLink Category:Antiandrogens.
- EPI-001 wikiPageWikiLink Category:Bisphenols.
- EPI-001 wikiPageWikiLink Category:Experimental_cancer_drugs.
- EPI-001 wikiPageWikiLink Category:Halohydrins.
- EPI-001 wikiPageWikiLink Category:Organochlorides.
- EPI-001 wikiPageWikiLink Category:PPAR_agonists.
- EPI-001 wikiPageWikiLink Category:Polyols.
- EPI-001 wikiPageWikiLink EPI-506.
- EPI-001 wikiPageWikiLink Endocrine_disruptor.
- EPI-001 wikiPageWikiLink Enzalutamide.
- EPI-001 wikiPageWikiLink GTF2F1.
- EPI-001 wikiPageWikiLink Galeterone.
- EPI-001 wikiPageWikiLink IC50.
- EPI-001 wikiPageWikiLink Mechanism_of_action.
- EPI-001 wikiPageWikiLink N-terminus.
- EPI-001 wikiPageWikiLink Nonsteroidal.
- EPI-001 wikiPageWikiLink Nuclear_receptor.
- EPI-001 wikiPageWikiLink ODM-201.
- EPI-001 wikiPageWikiLink Orteronel.
- EPI-001 wikiPageWikiLink Peroxisome_proliferator-activated_receptor_gamma.
- EPI-001 wikiPageWikiLink Pre-clinical_development.
- EPI-001 wikiPageWikiLink Prostate_cancer.
- EPI-001 wikiPageWikiLink Protein–protein_interaction.
- EPI-001 wikiPageWikiLink Receptor_antagonist.
- EPI-001 wikiPageWikiLink Selective_PPARγ_modulator.
- EPI-001 wikiPageWikiLink Stereoisomerism.
- EPI-001 wikiPageWikiLink Transcription_(genetics).
- EPI-001 wikiPageWikiLink University_of_British_Columbia.
- EPI-001 wikiPageWikiLink VT-464.
- EPI-001 wikiPageWikiLink Xenotransplantation.
- EPI-001 wikiPageWikiLinkText "EPI-001".
- EPI-001 c "21".
- EPI-001 chemspiderid "3378517".
- EPI-001 cl "1".
- EPI-001 h "27".
- EPI-001 inchi "1".
- EPI-001 inchikey "HDTYUHNZRYZEEB-UHFFFAOYAC".
- EPI-001 iupacName "3".
- EPI-001 legalStatus "Investigational".
- EPI-001 molecularWeight "394.89".
- EPI-001 o "5".
- EPI-001 pubchem "4166922".
- EPI-001 smiles "ClCCCOc1cccCC".
- EPI-001 stdinchi "1".
- EPI-001 stdinchikey "HDTYUHNZRYZEEB-UHFFFAOYSA-N".
- EPI-001 wikiPageUsesTemplate Template:Androgenics.
- EPI-001 wikiPageUsesTemplate Template:Antiandrogens.
- EPI-001 wikiPageUsesTemplate Template:Drugbox.
- EPI-001 wikiPageUsesTemplate Template:Nuclear_receptor_ligands.
- EPI-001 wikiPageUsesTemplate Template:Reflist.
- EPI-001 subject Category:Alkylating_agents.
- EPI-001 subject Category:Antiandrogens.
- EPI-001 subject Category:Bisphenols.
- EPI-001 subject Category:Experimental_cancer_drugs.
- EPI-001 subject Category:Halohydrins.
- EPI-001 subject Category:Organochlorides.
- EPI-001 subject Category:PPAR_agonists.
- EPI-001 subject Category:Polyols.
- EPI-001 hypernym Antiandrogen.
- EPI-001 type ChemicalSubstance.
- EPI-001 type Drug.
- EPI-001 type ChemicalObject.
- EPI-001 type Thing.
- EPI-001 type Q8386.
- EPI-001 comment "EPI-001 is a novel experimental non-steroidal antiandrogen that is under investigation for the treatment of prostate cancer.".
- EPI-001 label "EPI-001".
- EPI-001 sameAs Q15408409.
- EPI-001 sameAs m.0s8wgn2.
- EPI-001 sameAs EPI-001.
- EPI-001 sameAs EPI-001.
- EPI-001 sameAs Q15408409.
- EPI-001 wasDerivedFrom EPI-001?oldid=707247508.
- EPI-001 depiction EPI-001.svg.
- EPI-001 isPrimaryTopicOf EPI-001.