Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/EFNB3> ?p ?o }
Showing triples 1 to 52 of
52
with 100 triples per page.
- EFNB3 abstract "Ephrin-B3 is a protein that in humans is encoded by the EFNB3 gene.EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases. EPH receptors typically have a single kinase domain and an extracellular region containing a Cysteine-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997) based on their structures and sequence relationships. Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Ephrin-B ligands also contain an intracellular tail with highly conserved tyrosine residues and a PDZ-binding motif at the C-terminus. This tail functions as a mechanism for reverse signaling, where signaling occurs into the ligand-containing cell, as opposed to the cell with the receptor. Upon receptor-ligand interaction the tyrosine residues become phosphorylated and there is recruitment of PDZ domain-containing proteins. The Eph family of receptors are similarly divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.EphrinB3 has been implicated in mediating various developmental events, particularly in the nervous system. EphrinB3 reverse signaling is important for axon pruning and synapse and spine formation during postnatal development of the nervous system. Previous work has also shown that signaling through this ligand is important for radial migration during cortical development. Moreover, levels of EFNB3 expression are particularly high in several forebrain subregions compared to other brain subregions, and may play a pivotal role in forebrain function. It has been suggested that ephrinB3 signaling is necessary for synaptic plasticity to occur in the hippocampus; this implicates ephrinB3 as a major player in learning and memory. More recently, ephrinB3 has been shown to regulate proliferation of neural stem cells in the adult subventricular zone (SVZ).".
- EFNB3 entrezgene "1949".
- EFNB3 wikiPageID "14796524".
- EFNB3 wikiPageLength "8460".
- EFNB3 wikiPageOutDegree "15".
- EFNB3 wikiPageRevisionID "661010851".
- EFNB3 wikiPageWikiLink C-terminus.
- EFNB3 wikiPageWikiLink Ephrin.
- EFNB3 wikiPageWikiLink Forebrain.
- EFNB3 wikiPageWikiLink Gene.
- EFNB3 wikiPageWikiLink Glycophosphatidylinositol.
- EFNB3 wikiPageWikiLink Hippocampus.
- EFNB3 wikiPageWikiLink Kinase.
- EFNB3 wikiPageWikiLink Nervous_system.
- EFNB3 wikiPageWikiLink Neural_stem_cell.
- EFNB3 wikiPageWikiLink PDZ_domain.
- EFNB3 wikiPageWikiLink Protein.
- EFNB3 wikiPageWikiLink Receptor_tyrosine_kinase.
- EFNB3 wikiPageWikiLink Subventricular_zone.
- EFNB3 wikiPageWikiLink Synaptic_plasticity.
- EFNB3 wikiPageWikiLink Tyrosine.
- EFNB3 wikiPageWikiLinkText "EFNB3".
- EFNB3 wikiPageWikiLinkText "ephrin-B3".
- EFNB3 requireManualInspection "no".
- EFNB3 summaryText "EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases. EPH receptors typically have a single kinase domain and an extracellular region containing a Cysteine-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee based on their structures and sequence relationships. Ephrins are divided into the ephrin-A class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, which are transmembrane proteins. Ephrin-B ligands also contain an intracellular tail with highly conserved tyrosine residues and a PDZ-binding motif at the C-terminus. This tail functions as a mechanism for reverse signaling, where signaling occurs into the ligand-containing cell, as opposed to the cell with the receptor. Upon receptor-ligand interaction the tyrosine residues become phosphorylated and there is recruitment of PDZ domain-containing proteins. The Eph family of receptors are similarly divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.".
- EFNB3 updateCitations "yes".
- EFNB3 updatePage "yes".
- EFNB3 updateProteinBox "yes".
- EFNB3 updateSummary "yes".
- EFNB3 wikiPageUsesTemplate Template:Cite_journal.
- EFNB3 wikiPageUsesTemplate Template:Gene-17-stub.
- EFNB3 wikiPageUsesTemplate Template:Intercellular_signaling_peptides_and_proteins.
- EFNB3 wikiPageUsesTemplate Template:PBB.
- EFNB3 wikiPageUsesTemplate Template:PBB_Controls.
- EFNB3 wikiPageUsesTemplate Template:PBB_Further_reading.
- EFNB3 wikiPageUsesTemplate Template:PBB_Summary.
- EFNB3 wikiPageUsesTemplate Template:Refbegin.
- EFNB3 wikiPageUsesTemplate Template:Refend.
- EFNB3 wikiPageUsesTemplate Template:Reflist.
- EFNB3 hypernym Protein.
- EFNB3 type Biomolecule.
- EFNB3 type Protein.
- EFNB3 type Thing.
- EFNB3 type Q206229.
- EFNB3 type Q8054.
- EFNB3 comment "Ephrin-B3 is a protein that in humans is encoded by the EFNB3 gene.EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases. EPH receptors typically have a single kinase domain and an extracellular region containing a Cysteine-rich domain and 2 fibronectin type III repeats.".
- EFNB3 label "EFNB3".
- EFNB3 sameAs Q17916065.
- EFNB3 sameAs m.03gy7bm.
- EFNB3 sameAs Q17916065.
- EFNB3 wasDerivedFrom EFNB3?oldid=661010851.
- EFNB3 isPrimaryTopicOf EFNB3.