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- E-6837 abstract "E-6837 is an orally active, 5-HT6 agonist developed in an attempt to create an anti-obesity medication. In cell lines expressing rat 5-HT6 receptors, it acted as a partial agonist (on presumed silent receptors), while it acted as a full agonist on human 5-HT6 receptors (which are constitutively active). Oral administration of E-6837 reduced food intake, but only transiently. In rats, twice daily administration of E-6837 over the course of 4 weeks resulted in a 15.7% reduction in body weight, compared to 11% reduction for sibutramine. This weight loss remained significant for E-6837 after a 43 day withdrawal period, whereas the weight difference was non-significant for sibutramine (i.e., sibutramine had a rebound effect while E-6837 did not), and this weight loss was found to be due to a loss of fat mass. The reduction in fat mass in E-6837 treated animals was associated with a 50% decrease in plasma leptin levels, and also reduced glucose and insulin levels in plasma after a glucose tolerance test. This indicates that weight loss from E-6837 is associated with improved insulin sensitivity, and thus, better glycemic control. One proposed mechanism of action is that E-6837 acts on neurons in the hypothalamus, which has shown significant levels of 5-HT6 receptor mRNA. The hypothalamus is one key structure involved in regulating food intake.".
- E-6837 iupacName "5-chloro-N-(3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)naphthalene-2-sulfonamide".
- E-6837 thumbnail E_6837.svg?width=300.
- E-6837 wikiPageID "34172236".
- E-6837 wikiPageLength "3228".
- E-6837 wikiPageOutDegree "17".
- E-6837 wikiPageRevisionID "673922844".
- E-6837 wikiPageWikiLink 5-HT6_receptor.
- E-6837 wikiPageWikiLink Agonist.
- E-6837 wikiPageWikiLink Anti-obesity_medication.
- E-6837 wikiPageWikiLink Category:Anorectics.
- E-6837 wikiPageWikiLink Category:Chloroarenes.
- E-6837 wikiPageWikiLink Category:Naphthalenes.
- E-6837 wikiPageWikiLink Category:Serotonin_receptor_agonists.
- E-6837 wikiPageWikiLink Category:Tryptamines.
- E-6837 wikiPageWikiLink Diabetes_management.
- E-6837 wikiPageWikiLink E-6801.
- E-6837 wikiPageWikiLink Glucose_tolerance_test.
- E-6837 wikiPageWikiLink Insulin.
- E-6837 wikiPageWikiLink Leptin.
- E-6837 wikiPageWikiLink Partial_agonist.
- E-6837 wikiPageWikiLink Rebound_effect.
- E-6837 wikiPageWikiLink Receptor_(biochemistry).
- E-6837 wikiPageWikiLink Sibutramine.
- E-6837 wikiPageWikiLinkText "E-6837".
- E-6837 imagefile "E_6837.svg".
- E-6837 iupacname "5".
- E-6837 wikiPageUsesTemplate Template:Anorectics.
- E-6837 wikiPageUsesTemplate Template:Chembox.
- E-6837 wikiPageUsesTemplate Template:Chembox_Hazards.
- E-6837 wikiPageUsesTemplate Template:Chembox_Identifiers.
- E-6837 wikiPageUsesTemplate Template:Chembox_Properties.
- E-6837 wikiPageUsesTemplate Template:Reflist.
- E-6837 wikiPageUsesTemplate Template:Serotonergics.
- E-6837 wikiPageUsesTemplate Template:Tryptamines.
- E-6837 subject Category:Anorectics.
- E-6837 subject Category:Chloroarenes.
- E-6837 subject Category:Naphthalenes.
- E-6837 subject Category:Serotonin_receptor_agonists.
- E-6837 subject Category:Tryptamines.
- E-6837 type ChemicalCompound.
- E-6837 type ChemicalSubstance.
- E-6837 type Drug.
- E-6837 type Acene.
- E-6837 type Agonist.
- E-6837 type Drug.
- E-6837 type Organohalide.
- E-6837 type Organohalide.
- E-6837 type ChemicalObject.
- E-6837 type Thing.
- E-6837 type Q11173.
- E-6837 comment "E-6837 is an orally active, 5-HT6 agonist developed in an attempt to create an anti-obesity medication. In cell lines expressing rat 5-HT6 receptors, it acted as a partial agonist (on presumed silent receptors), while it acted as a full agonist on human 5-HT6 receptors (which are constitutively active). Oral administration of E-6837 reduced food intake, but only transiently.".
- E-6837 label "E-6837".
- E-6837 sameAs Q487493.
- E-6837 sameAs ایی-۶۸۳۷.
- E-6837 sameAs m.0hr9jcw.
- E-6837 sameAs E-6837.
- E-6837 sameAs E-6837.
- E-6837 sameAs Q487493.
- E-6837 wasDerivedFrom E-6837?oldid=673922844.
- E-6837 depiction E_6837.svg.
- E-6837 isPrimaryTopicOf E-6837.