Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Drug_discovery> ?p ?o }
- Drug_discovery abstract "In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, \"expensive, difficult, and inefficient process\" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The \"final product\" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.".
- Drug_discovery thumbnail Drug_discovery_cycle.svg?width=300.
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- Drug_discovery wikiPageExternalLink index.htm.
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- Drug_discovery wikiPageRevisionID "707754340".
- Drug_discovery wikiPageWikiLink ADME.
- Drug_discovery wikiPageWikiLink Aclarubicin.
- Drug_discovery wikiPageWikiLink Active_site.
- Drug_discovery wikiPageWikiLink Agonist.
- Drug_discovery wikiPageWikiLink Akira_Endo_(biochemist).
- Drug_discovery wikiPageWikiLink Allelopathy.
- Drug_discovery wikiPageWikiLink Amphibian.
- Drug_discovery wikiPageWikiLink Amrubicin.
- Drug_discovery wikiPageWikiLink Antitarget.
- Drug_discovery wikiPageWikiLink Arabinose.
- Drug_discovery wikiPageWikiLink Artemisia_annua.
- Drug_discovery wikiPageWikiLink Artemisinin.
- Drug_discovery wikiPageWikiLink Azathioprine.
- Drug_discovery wikiPageWikiLink Bcr-Abl_tyrosine-kinase_inhibitor.
- Drug_discovery wikiPageWikiLink Belotecan.
- Drug_discovery wikiPageWikiLink Beta2-adrenergic_agonist.
- Drug_discovery wikiPageWikiLink Beta_blocker.
- Drug_discovery wikiPageWikiLink Binding_selectivity.
- Drug_discovery wikiPageWikiLink Bioavailability.
- Drug_discovery wikiPageWikiLink Bioinformatics.
- Drug_discovery wikiPageWikiLink Biological_activity.
- Drug_discovery wikiPageWikiLink Biological_half-life.
- Drug_discovery wikiPageWikiLink Biological_target.
- Drug_discovery wikiPageWikiLink Biotechnology.
- Drug_discovery wikiPageWikiLink Blood–brain_barrier.
- Drug_discovery wikiPageWikiLink Bryostatin.
- Drug_discovery wikiPageWikiLink Cabazitaxel.
- Drug_discovery wikiPageWikiLink Caco-2.
- Drug_discovery wikiPageWikiLink Camptothecin.
- Drug_discovery wikiPageWikiLink Capital_intensity.
- Drug_discovery wikiPageWikiLink Category:Clinical_pharmacologists.
- Drug_discovery wikiPageWikiLink Category:Clinical_pharmacology.
- Drug_discovery wikiPageWikiLink Category:Clinical_research.
- Drug_discovery wikiPageWikiLink Category:Drug_discovery.
- Drug_discovery wikiPageWikiLink Category:Life_sciences_industry.
- Drug_discovery wikiPageWikiLink Category:Medicinal_chemistry.
- Drug_discovery wikiPageWikiLink Category:Pharmaceutical_industry.
- Drug_discovery wikiPageWikiLink Category:Pharmaceutics.
- Drug_discovery wikiPageWikiLink Category:Pharmacognosy.
- Drug_discovery wikiPageWikiLink Chemical_feasibility.
- Drug_discovery wikiPageWikiLink Chemical_library.
- Drug_discovery wikiPageWikiLink Chemical_space.
- Drug_discovery wikiPageWikiLink Cheminformatics.
- Drug_discovery wikiPageWikiLink Chirality_(chemistry).
- Drug_discovery wikiPageWikiLink Cimetidine.
- Drug_discovery wikiPageWikiLink Classical_pharmacology.
- Drug_discovery wikiPageWikiLink Clearance_(medicine).
- Drug_discovery wikiPageWikiLink Clinical_trial.
- Drug_discovery wikiPageWikiLink Combination_therapy.
- Drug_discovery wikiPageWikiLink Daunorubicin.
- Drug_discovery wikiPageWikiLink David_Jack_(scientist).
- Drug_discovery wikiPageWikiLink Digitalis_lanata.
- Drug_discovery wikiPageWikiLink Digoxin.
- Drug_discovery wikiPageWikiLink Discovery_and_development_of_antiandrogens.
- Drug_discovery wikiPageWikiLink Discovery_and_development_of_cephalosporins.
- Drug_discovery wikiPageWikiLink Discovery_and_development_of_nucleoside_and_nucleotide_reverse-transcriptase_inhibitors.
- Drug_discovery wikiPageWikiLink Discovery_and_development_of_proton_pump_inhibitors.
- Drug_discovery wikiPageWikiLink Doxorubicin.
- Drug_discovery wikiPageWikiLink Drug_design.
- Drug_discovery wikiPageWikiLink Drug_development.
- Drug_discovery wikiPageWikiLink Drug_metabolism.
- Drug_discovery wikiPageWikiLink Druglikeness.
- Drug_discovery wikiPageWikiLink Efficacy.
- Drug_discovery wikiPageWikiLink Enzyme_inhibitor.
- Drug_discovery wikiPageWikiLink Epirubicin.
- Drug_discovery wikiPageWikiLink Ethnobotany.
- Drug_discovery wikiPageWikiLink Ethnomedicine.
- Drug_discovery wikiPageWikiLink Etoposide.
- Drug_discovery wikiPageWikiLink Extract.
- Drug_discovery wikiPageWikiLink Food_and_Drug_Administration.
- Drug_discovery wikiPageWikiLink Fragment-based_lead_discovery.
- Drug_discovery wikiPageWikiLink Frog.
- Drug_discovery wikiPageWikiLink G_protein–coupled_receptor.
- Drug_discovery wikiPageWikiLink George_H._Hitchings.
- Drug_discovery wikiPageWikiLink Gertrude_B._Elion.
- Drug_discovery wikiPageWikiLink GlaxoSmithKline.
- Drug_discovery wikiPageWikiLink Grant_(money).
- Drug_discovery wikiPageWikiLink AIDS.
- Drug_discovery wikiPageWikiLink Health_informatics.
- Drug_discovery wikiPageWikiLink High-content_screening.
- Drug_discovery wikiPageWikiLink High-throughput_screening.
- Drug_discovery wikiPageWikiLink Hit_to_lead.
- Drug_discovery wikiPageWikiLink Human_Genome_Project.
- Drug_discovery wikiPageWikiLink Human_genome.
- Drug_discovery wikiPageWikiLink Idarubicin.
- Drug_discovery wikiPageWikiLink In_vitro.
- Drug_discovery wikiPageWikiLink In_vivo.
- Drug_discovery wikiPageWikiLink Investment.
- Drug_discovery wikiPageWikiLink Irinotecan.
- Drug_discovery wikiPageWikiLink James_Black_(pharmacologist).
- Drug_discovery wikiPageWikiLink Kaposis_sarcoma.
- Drug_discovery wikiPageWikiLink Lead_compound.