Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Drug_design> ?p ?o }
- Drug_design abstract "Drug design, sometimes referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques. This type of modeling is often referred to as computer-aided drug design. Finally, drug design that relies on the knowledge of the three-dimensional structure of the biomolecular target is known as structure-based drug design. In addition to small molecules, biopharmaceuticals and especially therapeutic antibodies are an increasingly important class of drugs and computational methods for improving the affinity, selectivity, and stability of these protein-based therapeutics have also been developed.The phrase \"drug design\" is to some extent a misnomer. A more accurate term is ligand design (i.e., design of a molecule that will bind tightly to its target). Although design techniques for prediction of binding affinity are reasonably successful, there are many other properties, such as bioavailability, metabolic half-life, side effects, etc., that first must be optimized before a ligand can become a safe and efficacious drug. These other characteristics are often difficult to predict with rational design techniques. Nevertheless, due to high attrition rates, especially during clinical phases of drug development, more attention is being focused early in the drug design process on selecting candidate drugs whose physicochemical properties are predicted to result in fewer complications during development and hence more likely to lead to an approved, marketed drug. Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles.".
- Drug_design thumbnail Drug_discovery_cycle.svg?width=300.
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- Drug_design wikiPageRevisionID "704149312".
- Drug_design wikiPageWikiLink 5-HT3_antagonist.
- Drug_design wikiPageWikiLink ADME.
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- Drug_design wikiPageWikiLink Adverse_drug_reaction.
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- Drug_design wikiPageWikiLink Binding_selectivity.
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- Drug_design wikiPageWikiLink Bioinformatics.
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- Drug_design wikiPageWikiLink Biological_half-life.
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- Drug_design wikiPageWikiLink C-Met_inhibitors.
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- Drug_design wikiPageWikiLink Category:Clinical_research.
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- Drug_design wikiPageWikiLink Category:Medicinal_chemistry.
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- Drug_design wikiPageWikiLink Discovery_and_development_of_angiotensin_receptor_blockers.
- Drug_design wikiPageWikiLink Discovery_and_development_of_cyclooxygenase_2_inhibitors.
- Drug_design wikiPageWikiLink Discovery_and_development_of_non-nucleoside_reverse-transcriptase_inhibitors.
- Drug_design wikiPageWikiLink Discovery_and_development_of_phosphodiesterase_5_inhibitors.
- Drug_design wikiPageWikiLink Discovery_and_development_of_proton_pump_inhibitors.
- Drug_design wikiPageWikiLink Discovery_and_development_of_triptans.
- Drug_design wikiPageWikiLink Dissociation_constant.
- Drug_design wikiPageWikiLink Docking_(molecular).
- Drug_design wikiPageWikiLink Dorzolamide.
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- Drug_design wikiPageWikiLink Hit_to_lead.
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- Drug_design wikiPageWikiLink Hydrophobe.
- Drug_design wikiPageWikiLink Imatinib.
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- Drug_design wikiPageWikiLink Infectivity.
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- Drug_design wikiPageWikiLink Leukemia.
- Drug_design wikiPageWikiLink Ligand_(biochemistry).
- Drug_design wikiPageWikiLink Linear_regression.
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- Drug_design wikiPageWikiLink Lipophilic_efficiency.
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- Drug_design wikiPageWikiLink Machine_learning.
- Drug_design wikiPageWikiLink Medicinal_chemistry.
- Drug_design wikiPageWikiLink Messenger_RNA.
- Drug_design wikiPageWikiLink Metabolic_pathway.
- Drug_design wikiPageWikiLink Microorganism.
- Drug_design wikiPageWikiLink Misnomer.
- Drug_design wikiPageWikiLink Molecular_cloning.