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- Draculin abstract "Draculin (named after Count Dracula) is a glycoprotein found in the saliva of vampire bats. It is composed of 411 amino acids, weighing about 88.5kDa. It functions as an anticoagulant, inhibiting coagulation factors IX (IXa) and X (Xa), thus keeping the blood of the bitten victim from clotting while the bat is drinking.Draculin is a reversible, slow tight binding, noncompetitive inhibitor of FXa. It does not act on thrombin, trypsin or chymotrypsin and does not express fibrinolytic activity. The protein increases the lag phase as well as the height of the peak of thrombin generation when in plasma, leading to prolonged bleeding. Daily salivation of vampire bats yields a saliva that progressively decreases in anticoagulant activity. However, there is no significant change in overall protein content during this time. After a 4-day period of rest, anticoagulant activity of the saliva is restored. In addition, purified native draculin, obtained from high- and low-activity saliva, shows significant differences in composition of the carbohydrate moiety, and glycosylation pattern. Furthermore, controlled chemical deglycosylation of native draculin progressively leads to complete loss of the biological activity, despite the conditions leaving the polypeptide backbone intact. Draculin is currently being explored in medicine. The anticoagulant may be useful as a treatment for strokes and heart attacks. It may also be used as a blood thinner for the prevention of heart attacks. The protein has shown promise when treating ischemic strokes, which account for the majority of strokes. It is effective for up to 9 hours. However, since the activity depends heavily on the proper glycosylation of the polypeptide backbone, more research is needed before draculin can become a practical, widely available drug.".
- Draculin thumbnail Desmoteplase_1A5I.png?width=300.
- Draculin wikiPageExternalLink 1848d3d4fdbdf17b001a72b2e7825c61.
- Draculin wikiPageID "1253725".
- Draculin wikiPageLength "3081".
- Draculin wikiPageOutDegree "17".
- Draculin wikiPageRevisionID "699179549".
- Draculin wikiPageWikiLink Amino_acid.
- Draculin wikiPageWikiLink Anticoagulant.
- Draculin wikiPageWikiLink Biochimica_et_Biophysica_Acta.
- Draculin wikiPageWikiLink Blood.
- Draculin wikiPageWikiLink Category:Anticoagulants.
- Draculin wikiPageWikiLink Category:Glycoproteins.
- Draculin wikiPageWikiLink Chymotrypsin.
- Draculin wikiPageWikiLink Coagulation.
- Draculin wikiPageWikiLink Count_Dracula.
- Draculin wikiPageWikiLink Factor_IX.
- Draculin wikiPageWikiLink Factor_X.
- Draculin wikiPageWikiLink Glycoprotein.
- Draculin wikiPageWikiLink Saliva.
- Draculin wikiPageWikiLink Thrombin.
- Draculin wikiPageWikiLink Trypsin.
- Draculin wikiPageWikiLink Vampire_bat.
- Draculin wikiPageWikiLink File:Desmoteplase_1A5I.png.
- Draculin wikiPageWikiLinkText "Draculin".
- Draculin wikiPageUsesTemplate Template:Merge.
- Draculin wikiPageUsesTemplate Template:Protein-stub.
- Draculin subject Category:Anticoagulants.
- Draculin subject Category:Glycoproteins.
- Draculin hypernym Glycoprotein.
- Draculin type Agent.
- Draculin type Protein.
- Draculin type Agent.
- Draculin type Anticoagulant.
- Draculin type Glycoprotein.
- Draculin comment "Draculin (named after Count Dracula) is a glycoprotein found in the saliva of vampire bats. It is composed of 411 amino acids, weighing about 88.5kDa. It functions as an anticoagulant, inhibiting coagulation factors IX (IXa) and X (Xa), thus keeping the blood of the bitten victim from clotting while the bat is drinking.Draculin is a reversible, slow tight binding, noncompetitive inhibitor of FXa. It does not act on thrombin, trypsin or chymotrypsin and does not express fibrinolytic activity.".
- Draculin label "Draculin".
- Draculin sameAs Q11046720.
- Draculin sameAs Draculine.
- Draculin sameAs דראקולין.
- Draculin sameAs Draculina.
- Draculin sameAs m.04mg9s.
- Draculin sameAs Q11046720.
- Draculin wasDerivedFrom Draculin?oldid=699179549.
- Draculin depiction Desmoteplase_1A5I.png.
- Draculin isPrimaryTopicOf Draculin.