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- Doubly_labeled_water abstract "Doubly labeled water is water in which both the hydrogen and the oxygen have been partly or completely replaced for tracing purposes (i.e. labeled) with an uncommon isotope of these elements.In practice, for both practical and safety reasons, almost all recent applications of the \"doubly labeled water\" method use water labeled with the heavy, non-radioactive forms of the elements deuterium and oxygen-18 (O-18 or 18O), or deuterium oxide-18 (D218O). In theory, radioactive forms of hydrogen and oxygen could be used for such labeling, and this was the case in many early applications of the method.In particular, use of the doubly labeled water method (or DLW method) yields a particular type of measurement of metabolic rate, in which the average metabolic rate of an organism is measured over a period of time. This is done by administering a dose of doubly labeled water, and then measuring the elimination rates of deuterium and O-18 in the subject over time through the regular sampling of heavy isotope concentrations in the body water (by sampling saliva, urine, or blood). The minimum number of samples required is two—an initial sample after the isotopes have reached equilibrium in the body, and a second sample some time later. The time between the collecting of these samples depends on size of the animal involved. In small animals the period may be as short as 24 hours, and in larger animals like adult humans, the period may be as long as 14 days. In animals this average daily metabolic rate measured by the DLW method is often also called the Field metabolic rate or FMR. The method was invented in the 1950s by Nathan Lifson and colleagues at the University of Minnesota; however, its use was restricted to small animals until the 1980s because of the high cost of the oxygen-18 isotope. Advances in mass spectrometry during the 1970s and early 1980s reduced the amount of isotope required, which made it feasible to apply the method to humans. The first application to humans was in 1982, by Dale Schoeller, over 25 years after the method was initially discovered. A complete summary of the technique is provided in a book by British biologist John Speakman.".
- Doubly_labeled_water wikiPageID "4680330".
- Doubly_labeled_water wikiPageLength "11541".
- Doubly_labeled_water wikiPageOutDegree "23".
- Doubly_labeled_water wikiPageRevisionID "701825292".
- Doubly_labeled_water wikiPageWikiLink Carbon_dioxide.
- Doubly_labeled_water wikiPageWikiLink Carbonic_anhydrase.
- Doubly_labeled_water wikiPageWikiLink Category:Calorimetry.
- Doubly_labeled_water wikiPageWikiLink Category:Isotopes.
- Doubly_labeled_water wikiPageWikiLink Category:Metabolism.
- Doubly_labeled_water wikiPageWikiLink Category:Water.
- Doubly_labeled_water wikiPageWikiLink Category:Water_chemistry.
- Doubly_labeled_water wikiPageWikiLink Chemical_element.
- Doubly_labeled_water wikiPageWikiLink Dale_Schoeller.
- Doubly_labeled_water wikiPageWikiLink Deuterium.
- Doubly_labeled_water wikiPageWikiLink Field_metabolic_rate.
- Doubly_labeled_water wikiPageWikiLink Heavy_water.
- Doubly_labeled_water wikiPageWikiLink Hydrogen.
- Doubly_labeled_water wikiPageWikiLink Isotope.
- Doubly_labeled_water wikiPageWikiLink John_Speakman.
- Doubly_labeled_water wikiPageWikiLink Kleibers_law.
- Doubly_labeled_water wikiPageWikiLink Nathan_Lifson.
- Doubly_labeled_water wikiPageWikiLink Oxygen.
- Doubly_labeled_water wikiPageWikiLink Oxygen-18.
- Doubly_labeled_water wikiPageWikiLink Respiratory_quotient.
- Doubly_labeled_water wikiPageWikiLinkText "Doubly labeled water".
- Doubly_labeled_water wikiPageWikiLinkText "doubly labeled water".
- Doubly_labeled_water wikiPageWikiLinkText "doubly labelled water".
- Doubly_labeled_water wikiPageWikiLinkText "use as a non-radioactive isotopic tracer".
- Doubly_labeled_water wikiPageUsesTemplate Template:Refbegin.
- Doubly_labeled_water wikiPageUsesTemplate Template:Reflist.
- Doubly_labeled_water subject Category:Calorimetry.
- Doubly_labeled_water subject Category:Isotopes.
- Doubly_labeled_water subject Category:Metabolism.
- Doubly_labeled_water subject Category:Water.
- Doubly_labeled_water subject Category:Water_chemistry.
- Doubly_labeled_water hypernym Water.
- Doubly_labeled_water type Building.
- Doubly_labeled_water type Isotope.
- Doubly_labeled_water type Liquid.
- Doubly_labeled_water type Physic.
- Doubly_labeled_water type Process.
- Doubly_labeled_water type Thermodynamic.
- Doubly_labeled_water comment "Doubly labeled water is water in which both the hydrogen and the oxygen have been partly or completely replaced for tracing purposes (i.e. labeled) with an uncommon isotope of these elements.In practice, for both practical and safety reasons, almost all recent applications of the \"doubly labeled water\" method use water labeled with the heavy, non-radioactive forms of the elements deuterium and oxygen-18 (O-18 or 18O), or deuterium oxide-18 (D218O).".
- Doubly_labeled_water label "Doubly labeled water".
- Doubly_labeled_water sameAs Q5300177.
- Doubly_labeled_water sameAs مياه_مميزة_بشكل_مزدوج.
- Doubly_labeled_water sameAs Acqua_doppiamente_marcata.
- Doubly_labeled_water sameAs m.0cg_91.
- Doubly_labeled_water sameAs Q5300177.
- Doubly_labeled_water wasDerivedFrom Doubly_labeled_water?oldid=701825292.
- Doubly_labeled_water isPrimaryTopicOf Doubly_labeled_water.