Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Dizocilpine> ?p ?o }
- Dizocilpine abstract "Dizocilpine (INN), also known as MK-801, is an uncompetitive antagonist of the N-Methyl-D-aspartate (NMDA) receptor, a glutamate receptor, discovered by a team at Merck in 1982. Glutamate is the brain's primary excitatory neurotransmitter. The channel is normally blocked with a magnesium ion and requires depolarization of the neuron to remove the magnesium and allow the glutamate to open the channel, causing an influx of calcium, which then leads to subsequent depolarization. Dizocilpine binds inside the ion channel of the receptor at several of PCP's binding sites thus preventing the flow of ions, including an influx of calcium (Ca2+), through the channel. Dizocilpine blocks NMDA receptors in a use- and voltage-dependent manner, since the channel must open for the drug to bind inside it. The drug acts as a potent anti-convulsant and likely has dissociative anesthetic properties, but it is not used clinically for this purpose due to the discovery of brain lesions, called Olney's lesions (see below), in test rats. Dizocilpine is also associated with a number of negative side effects, including cognitive disruption and psychotic-spectrum reactions. It also inhibited the induction of long term potentiation. Instead, the NMDA receptor pore-blocker ketamine is used as a dissociative anesthetic in human medical procedures. While ketamine may also trigger temporary psychosis in certain individuals, its short half-life and lower potency make it a much safer clinical option. However, dizocilpine is the most frequently used non-competitive NMDA receptor antagonist in animal models to mimic psychosis for experimental purposes.Dizocilpine has also been found to act as a nicotinic acetylcholine receptor antagonist. It has been shown to bind to and inhibit the serotonin and dopamine transporters as well.".
- Dizocilpine casNumber "77086-21-6".
- Dizocilpine drugbank "?".
- Dizocilpine fdaUniiCode "7PY8KH681I".
- Dizocilpine iupacName "[5R,10S]-[+]-5-methyl-10,11- dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine".
- Dizocilpine pubchem "180081".
- Dizocilpine thumbnail Dizocilpine.svg?width=300.
- Dizocilpine wikiPageExternalLink pmidlookup?view=long&pmid=3529096.
- Dizocilpine wikiPageExternalLink exp_Dizocilpine.shtml.
- Dizocilpine wikiPageID "1194091".
- Dizocilpine wikiPageLength "27633".
- Dizocilpine wikiPageOutDegree "78".
- Dizocilpine wikiPageRevisionID "696847247".
- Dizocilpine wikiPageWikiLink Alzheimers_disease.
- Dizocilpine wikiPageWikiLink Aminoglycoside.
- Dizocilpine wikiPageWikiLink Amnesia.
- Dizocilpine wikiPageWikiLink Amyotrophic_lateral_sclerosis.
- Dizocilpine wikiPageWikiLink Animal_model_of_schizophrenia.
- Dizocilpine wikiPageWikiLink Animal_models_of_depression.
- Dizocilpine wikiPageWikiLink Animal_testing.
- Dizocilpine wikiPageWikiLink Anticonvulsant.
- Dizocilpine wikiPageWikiLink Astrocyte.
- Dizocilpine wikiPageWikiLink Benzodiazepine.
- Dizocilpine wikiPageWikiLink Brain.
- Dizocilpine wikiPageWikiLink Calcium.
- Dizocilpine wikiPageWikiLink Category:Designer_drugs.
- Dizocilpine wikiPageWikiLink Category:Dibenzocycloheptenes.
- Dizocilpine wikiPageWikiLink Category:Dissociative_drugs.
- Dizocilpine wikiPageWikiLink Category:NMDA_receptor_antagonists.
- Dizocilpine wikiPageWikiLink Cell_culture.
- Dizocilpine wikiPageWikiLink Clinical_trial.
- Dizocilpine wikiPageWikiLink Conditioned_place_preference.
- Dizocilpine wikiPageWikiLink Depolarization.
- Dizocilpine wikiPageWikiLink Dextromethorphan.
- Dizocilpine wikiPageWikiLink Dibenzosuberenone.
- Dizocilpine wikiPageWikiLink Dissociative.
- Dizocilpine wikiPageWikiLink Dopamine_transporter.
- Dizocilpine wikiPageWikiLink Drug_overdose.
- Dizocilpine wikiPageWikiLink Epileptic_seizure.
- Dizocilpine wikiPageWikiLink Ethanol.
- Dizocilpine wikiPageWikiLink Excitotoxicity.
- Dizocilpine wikiPageWikiLink Glutamate_receptor.
- Dizocilpine wikiPageWikiLink Glutamic_acid.
- Dizocilpine wikiPageWikiLink Hallucination.
- Dizocilpine wikiPageWikiLink Heat_shock_protein.
- Dizocilpine wikiPageWikiLink Huntingtons_disease.
- Dizocilpine wikiPageWikiLink Hypokinesia.
- Dizocilpine wikiPageWikiLink International_nonproprietary_name.
- Dizocilpine wikiPageWikiLink Ion.
- Dizocilpine wikiPageWikiLink Ion_channel.
- Dizocilpine wikiPageWikiLink Ketamine.
- Dizocilpine wikiPageWikiLink L-DOPA.
- Dizocilpine wikiPageWikiLink Long-term_potentiation.
- Dizocilpine wikiPageWikiLink Merck_&_Co..
- Dizocilpine wikiPageWikiLink Microglia.
- Dizocilpine wikiPageWikiLink NMDA_receptor.
- Dizocilpine wikiPageWikiLink NMDA_receptor_antagonist.
- Dizocilpine wikiPageWikiLink Neurodegeneration.
- Dizocilpine wikiPageWikiLink Neuroglia.
- Dizocilpine wikiPageWikiLink Neuron.
- Dizocilpine wikiPageWikiLink Neurotransmitter.
- Dizocilpine wikiPageWikiLink Nicotinic_acetylcholine_receptor.
- Dizocilpine wikiPageWikiLink Nicotinic_antagonist.
- Dizocilpine wikiPageWikiLink Olneys_lesions.
- Dizocilpine wikiPageWikiLink Parkinsonism.
- Dizocilpine wikiPageWikiLink Phencyclidine.
- Dizocilpine wikiPageWikiLink Posterior_cingulate.
- Dizocilpine wikiPageWikiLink Prepulse_inhibition.
- Dizocilpine wikiPageWikiLink Psychosis.
- Dizocilpine wikiPageWikiLink Psychotomimetic.
- Dizocilpine wikiPageWikiLink Rabies.
- Dizocilpine wikiPageWikiLink Receptor_(biochemistry).
- Dizocilpine wikiPageWikiLink Reuptake_inhibitor.
- Dizocilpine wikiPageWikiLink Schizophrenia.
- Dizocilpine wikiPageWikiLink Serotonin_transporter.
- Dizocilpine wikiPageWikiLink Stroke.
- Dizocilpine wikiPageWikiLink Traumatic_brain_injury.
- Dizocilpine wikiPageWikiLink File:Dizocilpine_synthesis.png.
- Dizocilpine wikiPageWikiLink File:Dizocilpine_with_tube_model.png.
- Dizocilpine wikiPageWikiLinkText "Dizocilpine".
- Dizocilpine wikiPageWikiLinkText "dizocilpine".
- Dizocilpine bioavailability "?".
- Dizocilpine c "16".
- Dizocilpine casNumber "77086".
- Dizocilpine chembl "284237".
- Dizocilpine chemspiderid "156718".
- Dizocilpine drugbank "?".
- Dizocilpine eliminationHalfLife "?".
- Dizocilpine excretion "?".
- Dizocilpine h "15".
- Dizocilpine inchi "1".
- Dizocilpine inchikey "LBOJYSIDWZQNJS-CVEARBPZBY".
- Dizocilpine iupacName "[5R,10S]-[+]-5-methyl-10,11- dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine".
- Dizocilpine iupharLigand "2403".
- Dizocilpine meltingPoint "68.75".
- Dizocilpine metabolism "?".
- Dizocilpine molecularWeight "221.297".
- Dizocilpine n "1".
- Dizocilpine pubchem "180081".
- Dizocilpine routesOfAdministration "Oral, IM".