Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Discovery_and_development_of_direct_thrombin_inhibitors> ?p ?o }
- Discovery_and_development_of_direct_thrombin_inhibitors abstract "Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood clots caused by various diseases. They inhibit thrombin, a serine protease which affects the coagulation cascade in many ways. DTIs have undergone rapid development since the 90's. With technological advances in genetic engineering the production of recombinant hirudin was made possible which opened the door to this new group of drugs. Before the use of DTIs the therapy and prophylaxis for anticoagulation had stayed the same for over 50 years with the use of heparin derivatives and warfarin which have some well known disadvantages. DTIs are still under development, but the research focus has shifted towards factor Xa inhibitors, or even dual thrombin and fXa inhibitors that have a broader mechanism of action by both inhibiting factor IIa (thrombin) and Xa. A recent review of patents and literature on thrombin inhibitors has demonstrated that the development of allosteric and multi-mechanism inhibitors might lead the way to a safer anticoagulant.".
- Discovery_and_development_of_direct_thrombin_inhibitors thumbnail Svømmende_blodigle.JPG?width=300.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageID "37120076".
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageLength "33364".
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageOutDegree "196".
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageRevisionID "706128602".
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Absorption_(pharmacokinetics).
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Acid_dissociation_constant.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Active_site.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Acute_coronary_syndrome.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Aliphatic_compound.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Amidinium.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Anticoagulant.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Antidote.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Antithrombin.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Argatroban.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Arginine.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Aromaticity.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Aspartic_acid.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink AstraZeneca.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Atrial_fibrillation.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Bayer.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Benzamidine.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Benzimidazole.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Beta_barrel.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Bile_duct.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Biological_half-life.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Biological_target.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Bivalirudin.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Blood_plasma.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Blood_vessel.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Boehringer_Ingelheim.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Bolus_(medicine).
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink C-terminus.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Carbamate.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Carboxylate.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Catalysis.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Category:Anticoagulants.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Category:Articles_created_via_the_Article_Wizard.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Category:Direct_thrombin_inhibitors.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Category:Drug_discovery.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Clearance_(medicine).
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Clinical_trial.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Coagulation.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Cofactor_(biochemistry).
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Crystal_structure.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Cytochrome_P450.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Dabigatran.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Deep_vein_thrombosis.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Derivative_(chemistry).
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Direct_Xa_inhibitor.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Direct_thrombin_inhibitor.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Disease.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Dissociation_constant.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Divalent.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Dose–response_relationship.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Drug_development.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Embolism.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Enoxaparin_sodium.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Ester.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Excretion.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Exosite.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Factor_V.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Factor_VII.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Factor_VIII.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Factor_X.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Factor_XI.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Factor_XIII.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Fibrin.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Fibrinogen.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Fluid_compartments.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Food_and_Drug_Administration.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Genetic_engineering.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Glycine.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Guanidine.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Heparin.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Heparin-induced_thrombocytopenia.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Hip_replacement.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Hirudin.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Hirudo_medicinalis.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Histidine.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Human_gastrointestinal_tract.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Hydrogen_bond.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Hydrophobe.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Immune_disorder.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink In_vitro.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Indication_(medicine).
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Interaction.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Intravenous_therapy.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Isoleucine.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink John_Berry_Haycraft.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Knee_replacement.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Lepirudin.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Leucine.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Ligand_(biochemistry).
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Lipophilicity.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Liver.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Liver_disease.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Low_molecular_weight_heparin.
- Discovery_and_development_of_direct_thrombin_inhibitors wikiPageWikiLink Mechanism_of_action.