Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Discodermolide> ?p ?o }
- Discodermolide abstract "(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.".
- Discodermolide iupacName "[(3Z,5S,6S,7S,8R,9S,11Z,13S,14S,15S,16Z,18S)-8,14,18-Trihydroxy-19-[(2S,3R,4S,5R)-4-hydroxy-3,5-dimethyl-6-oxooxan-2-yl]-5,7,9,11,13,15-hexamethylnonadeca-1,3,11,16-tetraen-6-yl] carbamate".
- Discodermolide thumbnail Structure_of_discodermolide.png?width=300.
- Discodermolide wikiPageExternalLink 8209sci2.html.
- Discodermolide wikiPageExternalLink jiang-sem.pdf.
- Discodermolide wikiPageExternalLink 03March.shtm.
- Discodermolide wikiPageID "3325951".
- Discodermolide wikiPageLength "30002".
- Discodermolide wikiPageOutDegree "179".
- Discodermolide wikiPageRevisionID "705689467".
- Discodermolide wikiPageWikiLink 2-Oxazolidone.
- Discodermolide wikiPageWikiLink 3-hydroxy-2-methylpropionate.
- Discodermolide wikiPageWikiLink Acetylene.
- Discodermolide wikiPageWikiLink Aldehyde.
- Discodermolide wikiPageWikiLink Aldol_reaction.
- Discodermolide wikiPageWikiLink Alkene.
- Discodermolide wikiPageWikiLink Alkyl.
- Discodermolide wikiPageWikiLink Alkylation.
- Discodermolide wikiPageWikiLink Allyl.
- Discodermolide wikiPageWikiLink Amos_Smith.
- Discodermolide wikiPageWikiLink Amyloid.
- Discodermolide wikiPageWikiLink Antifungal.
- Discodermolide wikiPageWikiLink Apoptosis.
- Discodermolide wikiPageWikiLink Asymmetric_aldol.
- Discodermolide wikiPageWikiLink Asymmetric_allylation.
- Discodermolide wikiPageWikiLink Asymmetric_reduction.
- Discodermolide wikiPageWikiLink Axon.
- Discodermolide wikiPageWikiLink Benzyl.
- Discodermolide wikiPageWikiLink Beta-galactosidase.
- Discodermolide wikiPageWikiLink Boron_trifluoride.
- Discodermolide wikiPageWikiLink Cancer.
- Discodermolide wikiPageWikiLink Carbamate.
- Discodermolide wikiPageWikiLink Caribbean.
- Discodermolide wikiPageWikiLink Catalytic_triad.
- Discodermolide wikiPageWikiLink Category:Experimental_cancer_drugs.
- Discodermolide wikiPageWikiLink Category:Total_synthesis.
- Discodermolide wikiPageWikiLink Cell_cycle.
- Discodermolide wikiPageWikiLink Cell_growth.
- Discodermolide wikiPageWikiLink Chelation.
- Discodermolide wikiPageWikiLink Chemotherapy.
- Discodermolide wikiPageWikiLink Chiral_auxiliary.
- Discodermolide wikiPageWikiLink Clinical_trial.
- Discodermolide wikiPageWikiLink Conformational_isomerism.
- Discodermolide wikiPageWikiLink Convergence_(chemistry).
- Discodermolide wikiPageWikiLink Crosscoupling.
- Discodermolide wikiPageWikiLink Crotylsilane.
- Discodermolide wikiPageWikiLink Crotyltitanation.
- Discodermolide wikiPageWikiLink Crystallinity.
- Discodermolide wikiPageWikiLink Cytoplasm.
- Discodermolide wikiPageWikiLink Cytostasis.
- Discodermolide wikiPageWikiLink Danishefsky_diene.
- Discodermolide wikiPageWikiLink Diastereomer.
- Discodermolide wikiPageWikiLink Diels–Alder_reaction.
- Discodermolide wikiPageWikiLink Diene.
- Discodermolide wikiPageWikiLink Diisobutylaluminium_hydride.
- Discodermolide wikiPageWikiLink Diol.
- Discodermolide wikiPageWikiLink Discodermia_dissoluta.
- Discodermolide wikiPageWikiLink Dyotropic.
- Discodermolide wikiPageWikiLink Enol.
- Discodermolide wikiPageWikiLink Enzyme.
- Discodermolide wikiPageWikiLink Epothilone.
- Discodermolide wikiPageWikiLink Ether.
- Discodermolide wikiPageWikiLink Fermentation.
- Discodermolide wikiPageWikiLink File:Lung_cancer_cells_treated_with_discodermolide.jpg.
- Discodermolide wikiPageWikiLink File:Retrosynthetic_analyses_of_discodermolide.png.
- Discodermolide wikiPageWikiLink File:The_Ardisson_total_synthesis_of_(+)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_Evans_synthesis_of_(+)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_Evans_synthesis_of_(+)-discodermolide_fragment.png.
- Discodermolide wikiPageWikiLink File:The_Marshall_synthesis_of_(+)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_Marshall_synthesis_of_(+)-discodermolide_fragment.png.
- Discodermolide wikiPageWikiLink File:The_Myles_synthesis_of_(-)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_Novartis_60-g_total_synthesis_of_(+)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_Panek_total_synthesis_of_(+)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_Schreiber_synthesis_of_(-)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_Schreiber_synthesis_of_(-)-discodermolide_fragment.png.
- Discodermolide wikiPageWikiLink File:The_Smith_gram-scale_synthesis_of_(+)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_Smith_gram-scale_synthesis_of_(+)-discodermolide_fragment.png.
- Discodermolide wikiPageWikiLink File:The_Smith_synthesis_of_(-)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_Smith_synthesis_of_(-)-discodermolide_fragment.png.
- Discodermolide wikiPageWikiLink File:The_first-generation_Paterson_synthesis_of_(+)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_fourth-generation_Smith_synthesis_of_(+)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_second-generation_Paterson_syntheses_of_(+)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink File:The_third-generation_Paterson_syntheses_of_(+)-discodermolide_endgame.png.
- Discodermolide wikiPageWikiLink Glycidyl.
- Discodermolide wikiPageWikiLink Guanosine_triphosphate.
- Discodermolide wikiPageWikiLink Halide.
- Discodermolide wikiPageWikiLink Halogenation.
- Discodermolide wikiPageWikiLink Harbor_Branch_Oceanographic_Institute.
- Discodermolide wikiPageWikiLink Hemiacetal.
- Discodermolide wikiPageWikiLink Homologation.
- Discodermolide wikiPageWikiLink Horner–Wadsworth–Emmons_reaction.
- Discodermolide wikiPageWikiLink Immortalised_cell_line.
- Discodermolide wikiPageWikiLink Immunosuppression.
- Discodermolide wikiPageWikiLink In_vitro.
- Discodermolide wikiPageWikiLink In_vivo.
- Discodermolide wikiPageWikiLink Isomer.
- Discodermolide wikiPageWikiLink Kosan_Biosciences.
- Discodermolide wikiPageWikiLink Lactone.
- Discodermolide wikiPageWikiLink Lymphatic_system.
- Discodermolide wikiPageWikiLink Lymphocyte.