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- Dipropanoylmorphine abstract "Dipropanoylmorphine (Dipropionylmorphine in U.S. English) is an opiate derivative, the 3,6-dipropanoyl ester of morphine. It was developed in 1972 as an analgesic. It is rarely used in some countries for the relief of severe pain such as that caused by terminal cancer, as an alternative to diamorphine (heroin) and morphine. The drug was first synthesised circa or about 1875 in Great Britain along with many other esters of morphine, all of which were shelved at the time, some of which were later developed such as heroin (1898), acetylpropionylmorphine (1923), dibenzoylmorphine (1900 and/or 1924), and so on. The name of this drug is also given as 3,6-dipropanoylmorphine and its 6-mono-acetylated homologue is also a longer-acting heroin-like drug, as are 3,6-diformylmorphine and 6-formylmorphine.Dipropanoylmorphine, though rarely used, is considered to be a safer and less addictive alternative to morphine. Studies and clinical trials comparing dipropanoylmorphine to morphine have produced results that indicate the incidence of side-effects are far more common with morphine. Respiratory depression, euphoria, excessive sedation and somnolence (so-called 'nodding' by recreational opioid users), constipation, miosis (pinpoint pupils), nausea, bradycardia, behavioral disturbances, and severe physical and psychological dependence on morphine is more likely with the use of morphine versus dipropanoylmorphine.Dipropanoylmorphine is slightly slower acting than diamorphine and morphine, but longer lasting, and is slightly more potent by weight due to its higher lipophilicity. Side effects are generally relatively mild for an opioid with a similar profile to morphine/heroin and typical of other opioids. The most common side effects associated with dipropanoylmorphine are itching, nausea and respiratory depression.Dipropanoylmorphine is prepared by reacting morphine with propionic anhydride, in an analogous manner to how heroin is produced by reacting morphine with acetic anhydride.While acetic anhydride is a restricted chemical around the world due to its potential uses in making heroin from morphine for the illicit market, it is used in vast amounts by the chemical industry for the manufacture of drugs such as aspirin. Propanoic anhydride however is much less widely used. Although it is used in the manufacture of a range of pharmaceuticals, none of these are produced in nearly as large quantities, and sales of propanoic anhydride in quantities larger than one gram must be reported in many countries because of its potential use in making fentanyl type synthetic opiates.".
- Dipropanoylmorphine atcPrefix "none".
- Dipropanoylmorphine casNumber "10589-79-4".
- Dipropanoylmorphine iupacName "(5α,6α)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan 3,6-dipropionate".
- Dipropanoylmorphine pubchem "165894".
- Dipropanoylmorphine thumbnail Dipropanoylmorphine.svg?width=300.
- Dipropanoylmorphine wikiPageID "9162682".
- Dipropanoylmorphine wikiPageLength "5121".
- Dipropanoylmorphine wikiPageOutDegree "28".
- Dipropanoylmorphine wikiPageRevisionID "666563909".
- Dipropanoylmorphine wikiPageWikiLink Acetic_anhydride.
- Dipropanoylmorphine wikiPageWikiLink Acetylpropionylmorphine.
- Dipropanoylmorphine wikiPageWikiLink Analgesic.
- Dipropanoylmorphine wikiPageWikiLink Aspirin.
- Dipropanoylmorphine wikiPageWikiLink Bradycardia.
- Dipropanoylmorphine wikiPageWikiLink Cancer.
- Dipropanoylmorphine wikiPageWikiLink Category:Morphinans.
- Dipropanoylmorphine wikiPageWikiLink Category:Mu-opioid_agonists.
- Dipropanoylmorphine wikiPageWikiLink Category:Opioids.
- Dipropanoylmorphine wikiPageWikiLink Category:Propionates.
- Dipropanoylmorphine wikiPageWikiLink Category:Semisynthetic_opioids.
- Dipropanoylmorphine wikiPageWikiLink Dibenzoylmorphine.
- Dipropanoylmorphine wikiPageWikiLink Ester.
- Dipropanoylmorphine wikiPageWikiLink Euphoria.
- Dipropanoylmorphine wikiPageWikiLink Fentanyl.
- Dipropanoylmorphine wikiPageWikiLink Heroin.
- Dipropanoylmorphine wikiPageWikiLink Hypoventilation.
- Dipropanoylmorphine wikiPageWikiLink Itch.
- Dipropanoylmorphine wikiPageWikiLink Miosis.
- Dipropanoylmorphine wikiPageWikiLink Morphine.
- Dipropanoylmorphine wikiPageWikiLink Nausea.
- Dipropanoylmorphine wikiPageWikiLink Opiate.
- Dipropanoylmorphine wikiPageWikiLink Opioid.
- Dipropanoylmorphine wikiPageWikiLink Pain.
- Dipropanoylmorphine wikiPageWikiLink Propionic_anhydride.
- Dipropanoylmorphine wikiPageWikiLinkText "Dipropanoylmorphine".
- Dipropanoylmorphine wikiPageWikiLinkText "dipropanoylmorphine".
- Dipropanoylmorphine atcPrefix "none".
- Dipropanoylmorphine c "23".
- Dipropanoylmorphine casNumber "10589".
- Dipropanoylmorphine chemspiderid "145387".
- Dipropanoylmorphine h "27".
- Dipropanoylmorphine inchi "1".
- Dipropanoylmorphine inchikey "KDFWILUISXRMIK-LISRSHBKBL".
- Dipropanoylmorphine iupacName "-78".
- Dipropanoylmorphine legalUs "Schedule I".
- Dipropanoylmorphine molecularWeight "397.464".
- Dipropanoylmorphine n "1".
- Dipropanoylmorphine o "5".
- Dipropanoylmorphine pubchem "165894".
- Dipropanoylmorphine smiles "CCCc3c1C[C@H]4NCC[C@@]25[C@@H][C@@H]\C=C/[C@@H]45".
- Dipropanoylmorphine stdinchi "1".
- Dipropanoylmorphine stdinchikey "KDFWILUISXRMIK-LISRSHBKSA-N".
- Dipropanoylmorphine synonyms "Dipropanoylmorphine, Dipropionylmorphine".
- Dipropanoylmorphine verifiedrevid "437356401".
- Dipropanoylmorphine width "200".
- Dipropanoylmorphine wikiPageUsesTemplate Template:Chemspidercite.
- Dipropanoylmorphine wikiPageUsesTemplate Template:Drugbankcite.
- Dipropanoylmorphine wikiPageUsesTemplate Template:Drugbox.
- Dipropanoylmorphine wikiPageUsesTemplate Template:Opioidergics.
- Dipropanoylmorphine wikiPageUsesTemplate Template:Reflist.
- Dipropanoylmorphine wikiPageUsesTemplate Template:Stdinchicite.
- Dipropanoylmorphine subject Category:Morphinans.
- Dipropanoylmorphine subject Category:Mu-opioid_agonists.
- Dipropanoylmorphine subject Category:Opioids.
- Dipropanoylmorphine subject Category:Propionates.
- Dipropanoylmorphine subject Category:Semisynthetic_opioids.
- Dipropanoylmorphine type ChemicalSubstance.
- Dipropanoylmorphine type Drug.
- Dipropanoylmorphine type Agonist.
- Dipropanoylmorphine type Alkaloid.
- Dipropanoylmorphine type Analgesic.
- Dipropanoylmorphine type Drug.
- Dipropanoylmorphine type Heterocycle.
- Dipropanoylmorphine type Opioid.
- Dipropanoylmorphine type ChemicalObject.
- Dipropanoylmorphine type Thing.
- Dipropanoylmorphine type Q8386.
- Dipropanoylmorphine comment "Dipropanoylmorphine (Dipropionylmorphine in U.S. English) is an opiate derivative, the 3,6-dipropanoyl ester of morphine. It was developed in 1972 as an analgesic. It is rarely used in some countries for the relief of severe pain such as that caused by terminal cancer, as an alternative to diamorphine (heroin) and morphine.".
- Dipropanoylmorphine label "Dipropanoylmorphine".
- Dipropanoylmorphine sameAs Q5280075.
- Dipropanoylmorphine sameAs m.027ztkt.
- Dipropanoylmorphine sameAs Dipropanoilmorfin.
- Dipropanoylmorphine sameAs Dipropanoilmorfin.
- Dipropanoylmorphine sameAs Q5280075.
- Dipropanoylmorphine wasDerivedFrom Dipropanoylmorphine?oldid=666563909.
- Dipropanoylmorphine depiction Dipropanoylmorphine.svg.
- Dipropanoylmorphine isPrimaryTopicOf Dipropanoylmorphine.