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- Dipicolinic_acid abstract "Dipicolinic acid (pyridine-2,6-dicarboxylic acid or PDC and DPA) is a chemical compound which composes 5% to 15% of the dry weight of bacterial spores. It is implicated as responsible for the heat resistance of the endospore.However, mutants resistant to heat but lacking dipicolinic acid have been isolated, suggesting other mechanisms contributing to heat resistance are at work.Dipicolinic acid forms a complex with calcium ions within the endospore core. This complex binds free water molecules, causing dehydration of the spore. As a result, the heat resistance of macromolecules within the core increases. The calcium-dipicolinic acid complex also functions to protect DNA from heat denaturation by inserting itself between the nucleobases, thereby increasing the stability of DNA.Two genera of bacterial pathogens are known to produce endospores: the aerobic Bacillus and anaerobic Clostridium.Adrian Ponce, a chemist at the Jet Propulsion Laboratory has developed a technique for the detection of germinable endospores by staining dipicolinic acid with terbium. When the area is illuminated under ultraviolet light, live endospores glow in the presence of the terbium. The technique was developed for the validation of Spacecraft cleanliness, but it promises applications for the assessment of sterility more generally. The technique has the advantage of much greater speed over culture-based methods of endospore detection.It is also used to prepare dipicolinato ligated lanthanide and transition metal complexes for ion chromatography.".
- Dipicolinic_acid iupacName "Pyridine-2,6-dicarboxylic acid".
- Dipicolinic_acid thumbnail Dipicolinic_acid.png?width=300.
- Dipicolinic_acid wikiPageExternalLink spotting-spores.
- Dipicolinic_acid wikiPageExternalLink endospore20091019.html.
- Dipicolinic_acid wikiPageID "19062112".
- Dipicolinic_acid wikiPageLength "5161".
- Dipicolinic_acid wikiPageOutDegree "17".
- Dipicolinic_acid wikiPageRevisionID "703683579".
- Dipicolinic_acid wikiPageWikiLink Bacillus.
- Dipicolinic_acid wikiPageWikiLink Bacteria.
- Dipicolinic_acid wikiPageWikiLink Calcium.
- Dipicolinic_acid wikiPageWikiLink Category:Dicarboxylic_acids.
- Dipicolinic_acid wikiPageWikiLink Category:Pyridines.
- Dipicolinic_acid wikiPageWikiLink Chromatography.
- Dipicolinic_acid wikiPageWikiLink Clostridium.
- Dipicolinic_acid wikiPageWikiLink Coordination_complex.
- Dipicolinic_acid wikiPageWikiLink DNA.
- Dipicolinic_acid wikiPageWikiLink Endospore.
- Dipicolinic_acid wikiPageWikiLink Interplanetary_contamination.
- Dipicolinic_acid wikiPageWikiLink Jet_Propulsion_Laboratory.
- Dipicolinic_acid wikiPageWikiLink Lanthanide.
- Dipicolinic_acid wikiPageWikiLink Nucleobase.
- Dipicolinic_acid wikiPageWikiLink Terbium.
- Dipicolinic_acid wikiPageWikiLink Transition_metal.
- Dipicolinic_acid wikiPageWikiLinkText "Dipicolinic acid".
- Dipicolinic_acid wikiPageWikiLinkText "calcium dipicolinate".
- Dipicolinic_acid wikiPageWikiLinkText "dipicolinate".
- Dipicolinic_acid wikiPageWikiLinkText "dipicolinic acid".
- Dipicolinic_acid imagefile "Dipicolinic acid.png".
- Dipicolinic_acid imagesize "180".
- Dipicolinic_acid iupacname "Pyridine-2,6-dicarboxylic acid".
- Dipicolinic_acid othernames "26".
- Dipicolinic_acid verifiedrevid "443696483".
- Dipicolinic_acid watchedfields "changed".
- Dipicolinic_acid wikiPageUsesTemplate Template:Cascite.
- Dipicolinic_acid wikiPageUsesTemplate Template:Chembox.
- Dipicolinic_acid wikiPageUsesTemplate Template:Chembox_Hazards.
- Dipicolinic_acid wikiPageUsesTemplate Template:Chembox_Identifiers.
- Dipicolinic_acid wikiPageUsesTemplate Template:Chembox_Properties.
- Dipicolinic_acid wikiPageUsesTemplate Template:Chemspidercite.
- Dipicolinic_acid wikiPageUsesTemplate Template:Drugbankcite.
- Dipicolinic_acid wikiPageUsesTemplate Template:Ebicite.
- Dipicolinic_acid wikiPageUsesTemplate 38.
- Dipicolinic_acid wikiPageUsesTemplate Template:Reflist.
- Dipicolinic_acid wikiPageUsesTemplate Template:S26.
- Dipicolinic_acid wikiPageUsesTemplate Template:S36.
- Dipicolinic_acid wikiPageUsesTemplate Template:Stdinchicite.
- Dipicolinic_acid subject Category:Dicarboxylic_acids.
- Dipicolinic_acid subject Category:Pyridines.
- Dipicolinic_acid hypernym Compound.
- Dipicolinic_acid type ChemicalCompound.
- Dipicolinic_acid type ChemicalSubstance.
- Dipicolinic_acid type Heterocycle.
- Dipicolinic_acid type ChemicalObject.
- Dipicolinic_acid type Thing.
- Dipicolinic_acid type Q11173.
- Dipicolinic_acid comment "Dipicolinic acid (pyridine-2,6-dicarboxylic acid or PDC and DPA) is a chemical compound which composes 5% to 15% of the dry weight of bacterial spores. It is implicated as responsible for the heat resistance of the endospore.However, mutants resistant to heat but lacking dipicolinic acid have been isolated, suggesting other mechanisms contributing to heat resistance are at work.Dipicolinic acid forms a complex with calcium ions within the endospore core.".
- Dipicolinic_acid label "Dipicolinic acid".
- Dipicolinic_acid sameAs Q417164.
- Dipicolinic_acid sameAs Dipicolinsäure.
- Dipicolinic_acid sameAs دیپیکولینیک_اسید.
- Dipicolinic_acid sameAs Acido_dipicolinico.
- Dipicolinic_acid sameAs ジピコリン酸.
- Dipicolinic_acid sameAs Kwas_dipikolinowy.
- Dipicolinic_acid sameAs m.04jf5m8.
- Dipicolinic_acid sameAs Dipikolinska_kiselina.
- Dipicolinic_acid sameAs Dipikolinska_kiselina.
- Dipicolinic_acid sameAs Q417164.
- Dipicolinic_acid wasDerivedFrom Dipicolinic_acid?oldid=703683579.
- Dipicolinic_acid depiction Dipicolinic_acid.png.
- Dipicolinic_acid isPrimaryTopicOf Dipicolinic_acid.