Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Difelikefalin> ?p ?o }
- Difelikefalin abstract "Difelikefalin (INN) (developmental code names CR845, FE-202845), also known as D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid] (as the acetate salt), is an analgesic opioid peptide acting as a peripherally-specific, highly selective agonist of the κ-opioid receptor (KOR). It is under development by Cara Therapeutics as an intravenous agent for the treatment of postoperative pain. An oral formulation has also been developed. Due to its peripheral selectivity, difelikefalin lacks the central side effects like sedation, dysphoria, and hallucinations of previous KOR-acting analgesics such as pentazocine and phenazocine. In addition to use as an analgesic, difelikefalin is also being investigated for the treatment of pruritus (itching). Difelikefalin has completed phase II clinical trials for postoperative pain and has demonstrated significant and \"robust\" clinical efficacy, along with being safe and well-tolerated. It is also in phase II clinical trials for uremic pruritus in hemodialysis patients.Difelikefalin acts as an analgesic by activating KORs on peripheral nerve terminals and KORs expressed by certain immune system cells. Activation of KORs on peripheral nerve terminals results in the inhibition of ion channels responsible for afferent nerve activity, causing reduced transmission of pain signals, while activation of KORs expressed by immune system cells results in reduced release of proinflammatory, nerve-sensitizing mediators (e.g., prostaglandins).".
- Difelikefalin atcPrefix "None".
- Difelikefalin bioavailability "100.0".
- Difelikefalin casNumber "1024828-77-0".
- Difelikefalin iupacName "4-Amino-1-((D)-phenylalanyl-(D)-phenylalanyl-(D)-leucyl-(D)-lysyl)piperidine-4-carboxylic acid".
- Difelikefalin thumbnail Difelikefalin.svg?width=300.
- Difelikefalin wikiPageExternalLink 800028218.
- Difelikefalin wikiPageExternalLink cr845.shtml.
- Difelikefalin wikiPageID "48181230".
- Difelikefalin wikiPageLength "6106".
- Difelikefalin wikiPageOutDegree "59".
- Difelikefalin wikiPageRevisionID "702940781".
- Difelikefalin wikiPageWikiLink Acetate.
- Difelikefalin wikiPageWikiLink Afferent_nerve_fiber.
- Difelikefalin wikiPageWikiLink Agonist.
- Difelikefalin wikiPageWikiLink Analgesic.
- Difelikefalin wikiPageWikiLink Asimadoline.
- Difelikefalin wikiPageWikiLink Bile.
- Difelikefalin wikiPageWikiLink Butorphanol.
- Difelikefalin wikiPageWikiLink CR665.
- Difelikefalin wikiPageWikiLink Cara_Therapeutics.
- Difelikefalin wikiPageWikiLink Casokefamide.
- Difelikefalin wikiPageWikiLink Category:Amines.
- Difelikefalin wikiPageWikiLink Category:Antipruritics.
- Difelikefalin wikiPageWikiLink Category:Carboxylic_acids.
- Difelikefalin wikiPageWikiLink Category:Kappa_agonists.
- Difelikefalin wikiPageWikiLink Category:Opioid_peptides.
- Difelikefalin wikiPageWikiLink Category:Peripherally_selective_drugs.
- Difelikefalin wikiPageWikiLink Category:Piperidines.
- Difelikefalin wikiPageWikiLink Central_nervous_system.
- Difelikefalin wikiPageWikiLink Clinical_trial.
- Difelikefalin wikiPageWikiLink Dynorphin.
- Difelikefalin wikiPageWikiLink Dysphoria.
- Difelikefalin wikiPageWikiLink Eluxadoline.
- Difelikefalin wikiPageWikiLink Eptazocine.
- Difelikefalin wikiPageWikiLink Fedotozine.
- Difelikefalin wikiPageWikiLink Frakefamide.
- Difelikefalin wikiPageWikiLink GR-89696.
- Difelikefalin wikiPageWikiLink Hallucination.
- Difelikefalin wikiPageWikiLink Hemodialysis.
- Difelikefalin wikiPageWikiLink ICI-204,448.
- Difelikefalin wikiPageWikiLink Immune_system.
- Difelikefalin wikiPageWikiLink Inflammation.
- Difelikefalin wikiPageWikiLink International_nonproprietary_name.
- Difelikefalin wikiPageWikiLink Intravenous_therapy.
- Difelikefalin wikiPageWikiLink Ion_channel.
- Difelikefalin wikiPageWikiLink Itch.
- Difelikefalin wikiPageWikiLink Nalbuphine.
- Difelikefalin wikiPageWikiLink Nalfurafine.
- Difelikefalin wikiPageWikiLink Nalorphine.
- Difelikefalin wikiPageWikiLink Nerve.
- Difelikefalin wikiPageWikiLink Neurotransmission.
- Difelikefalin wikiPageWikiLink Nociceptor.
- Difelikefalin wikiPageWikiLink Opioid_peptide.
- Difelikefalin wikiPageWikiLink Oral_administration.
- Difelikefalin wikiPageWikiLink Pain.
- Difelikefalin wikiPageWikiLink Pentazocine.
- Difelikefalin wikiPageWikiLink Peripherally-selective_drug.
- Difelikefalin wikiPageWikiLink Phases_of_clinical_research.
- Difelikefalin wikiPageWikiLink Phenazocine.
- Difelikefalin wikiPageWikiLink Prostaglandin.
- Difelikefalin wikiPageWikiLink Salt.
- Difelikefalin wikiPageWikiLink Sedation.
- Difelikefalin wikiPageWikiLink Side_effect.
- Difelikefalin wikiPageWikiLink Uremic_pruritus.
- Difelikefalin wikiPageWikiLink Urine.
- Difelikefalin wikiPageWikiLink White_blood_cell.
- Difelikefalin wikiPageWikiLink Zyklophin.
- Difelikefalin wikiPageWikiLink Κ-opioid_receptor.
- Difelikefalin wikiPageWikiLinkText "Difelikefalin (CR845)".
- Difelikefalin wikiPageWikiLinkText "Difelikefalin".
- Difelikefalin atcPrefix "None".
- Difelikefalin bioavailability "100.0".
- Difelikefalin c "36".
- Difelikefalin casNumber "1024828".
- Difelikefalin eliminationHalfLife "7200.0".
- Difelikefalin excretion "Excreted as unchanged".
- Difelikefalin excretion "drug via bile and urine".
- Difelikefalin h "53".
- Difelikefalin iupacName "4".
- Difelikefalin metabolism "Not metabolized".
- Difelikefalin molecularWeight "679.85".
- Difelikefalin n "7".
- Difelikefalin o "6".
- Difelikefalin routesOfAdministration Intravenous_therapy.
- Difelikefalin wikiPageUsesTemplate Template:Analgesic-stub.
- Difelikefalin wikiPageUsesTemplate Template:Analgesics.
- Difelikefalin wikiPageUsesTemplate Template:Antipruritics.
- Difelikefalin wikiPageUsesTemplate Template:Drugbox.
- Difelikefalin wikiPageUsesTemplate Template:Opioidergics.
- Difelikefalin wikiPageUsesTemplate Template:Reflist.
- Difelikefalin subject Category:Amines.
- Difelikefalin subject Category:Antipruritics.
- Difelikefalin subject Category:Carboxylic_acids.
- Difelikefalin subject Category:Kappa_agonists.
- Difelikefalin subject Category:Opioid_peptides.
- Difelikefalin subject Category:Peripherally_selective_drugs.
- Difelikefalin subject Category:Piperidines.
- Difelikefalin hypernym Peptide.
- Difelikefalin type ChemicalCompound.