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- Dietary_exposure_assessments_in_the_United_States abstract "Dietary exposure assessments involve the evaluation of dietary consumption and chemical residue data while taking into consideration additional factors that may affect a specified population of interest or sensitive population. The process of conducting a dietary exposure assessment involves the determination of the chemical residues on a particular food or foods and the calculation of the dietary exposure to these chemicals based on consumption data for the specified food or foods. In the most simplified form, a dietary exposure assessment can be summarized with the following calculation: Dietary exposure = food consumption X food chemical concentrationThe purpose of calculating dietary exposure to a given chemical or contaminant is so the estimated dietary exposure can be compared to a relevant health standard such as the acceptable daily intake (ADI), the acute reference dose (ARfD) or reference dose (RfD), or a level known to cause adverse effects in animal or human health studies. From this comparison, one can begin to assess the risk of adverse effects from a chemical or contaminant due to dietary exposure.Quantifying dietary exposure most often involves the use of models. Dietary exposure models vary in complexity depending on the tier, or level of detail of the assessment in which they are utilized. Lower tier models may be deterministic and use single point estimates for inputs whereas higher tier models may be more stochastic, utilizing probabilistic inputs. Simple dietary exposure models calculate dietary intake of the chemical of concern as the product of the mass of the food item consumed during the specified time period and the average concentration of the contaminant in the item. This basic approach is also used in more complex models; however, the contributions of various food items and types are summed as inputs. Exposure model outputs can be expressed as a single point estimates or as a probability distribution. In general, the more robust and extensive the input data, the more accurate the estimate of exposure.Modeling dietary exposure is important to support dietary risk assessments. Validated dietary exposure models can be used in total ingestion studies which focus on the level of exposure to a contaminant from all food sources and they can also be used in aggregate exposure models which may include exposure to a chemical or contaminant through additional means of exposure such as inhalation and dermal or skin contact exposure. In addition, dietary exposure models are useful for identifying at risk populations and potential exposure “hot-spots”. For government agencies, modeling dietary exposure is especially useful in estimating possible exposure to a chemical during a pre-market review. An example of such review would the evaluation of a new pesticide by the Environmental Protection Agency (EPA) to determine if it is safe for use or to determine regulations to control such use.".
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- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Category:Food_law.
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- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Dermis.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Determinism.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Food_Quality_Protection_Act.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Food_and_Agriculture_Organization.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Fungicide.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Herbicide.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Inhalation.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Insecticide.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Monte_Carlo_method.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Mycotoxin.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Pesticide.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Phycotoxin.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Phytotoxin.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Reference_dose.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Stochastic.
- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLink Toxic_heavy_metal.
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- Dietary_exposure_assessments_in_the_United_States wikiPageWikiLinkText "Dietary exposure assessments in the United States".
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- Dietary_exposure_assessments_in_the_United_States subject Category:Food_law.
- Dietary_exposure_assessments_in_the_United_States subject Category:Food_safety_in_the_United_States.
- Dietary_exposure_assessments_in_the_United_States comment "Dietary exposure assessments involve the evaluation of dietary consumption and chemical residue data while taking into consideration additional factors that may affect a specified population of interest or sensitive population. The process of conducting a dietary exposure assessment involves the determination of the chemical residues on a particular food or foods and the calculation of the dietary exposure to these chemicals based on consumption data for the specified food or foods.".
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