Matches in DBpedia 2016-04 for { <http://dbpedia.org/resource/Deramciclane> ?p ?o }
- Deramciclane abstract "Deramciclane (EGIS-3886) is a non-benzodiazepine-type anxiolytic drug to treat various types of anxiety disorders, which 40-80 million people in the world suffer from. Deramciclane is a unique alternative to current anxiolytics on the market because it has a novel chemical structure and target. It acts as an antagonist at the 5-HT2A receptor, as an inverse agonist at the 5-HT2C receptor, and as a GABA reuptake inhibitor. The two serotonin receptors are G protein-coupled receptors and are two of the main excitatory serotonin receptor types. Their excitation has been implicated in anxiety and mood. Deramciclane does not affect CYP3A4 activity in metabolizing other drugs, but it is a weak inhibitor of CYP2D6. Some studies also show the drug to have moderate affinity to dopamine D2 receptors and low affinity to dopamine receptor D1. Researchers are looking for alternatives to benzodiazepines for anxiolytic use because benzodiazepine drugs have sedative and muscle relaxant side effects.".
- Deramciclane atcPrefix "none".
- Deramciclane casNumber "120444-72-6".
- Deramciclane fdaUniiCode "O5KFK61E74".
- Deramciclane iupacName "N,N-dimethyl-2-([(1R,4R,6S)-1,7,7-trimethyl-6-phenyl-6-bicyclo[2.2.1]heptanyl]oxy)ethanamine".
- Deramciclane pubchem "119590".
- Deramciclane thumbnail Deramciclane.svg?width=300.
- Deramciclane wikiPageID "18589073".
- Deramciclane wikiPageLength "17907".
- Deramciclane wikiPageOutDegree "38".
- Deramciclane wikiPageRevisionID "683962185".
- Deramciclane wikiPageWikiLink 5-HT2A_receptor.
- Deramciclane wikiPageWikiLink 5-HT2C_receptor.
- Deramciclane wikiPageWikiLink Anxiety_disorder.
- Deramciclane wikiPageWikiLink Anxiolytic.
- Deramciclane wikiPageWikiLink Benzodiazepine.
- Deramciclane wikiPageWikiLink Bioavailability.
- Deramciclane wikiPageWikiLink Blood_pressure.
- Deramciclane wikiPageWikiLink Blood–brain_barrier.
- Deramciclane wikiPageWikiLink CYP2D6.
- Deramciclane wikiPageWikiLink CYP3A4.
- Deramciclane wikiPageWikiLink Category:5-HT2A_antagonists.
- Deramciclane wikiPageWikiLink Category:GABA_reuptake_inhibitors.
- Deramciclane wikiPageWikiLink Cmax.
- Deramciclane wikiPageWikiLink Dopamine_receptor_D1.
- Deramciclane wikiPageWikiLink Dopamine_receptor_D2.
- Deramciclane wikiPageWikiLink Drug_metabolism.
- Deramciclane wikiPageWikiLink Electrocardiography.
- Deramciclane wikiPageWikiLink Enzyme.
- Deramciclane wikiPageWikiLink GABA_reuptake_inhibitor.
- Deramciclane wikiPageWikiLink G_protein–coupled_receptor.
- Deramciclane wikiPageWikiLink Generalized_anxiety_disorder.
- Deramciclane wikiPageWikiLink Half-life.
- Deramciclane wikiPageWikiLink Hamilton_Anxiety_Rating_Scale.
- Deramciclane wikiPageWikiLink Hepatocyte.
- Deramciclane wikiPageWikiLink High-density_lipoprotein.
- Deramciclane wikiPageWikiLink Inverse_agonist.
- Deramciclane wikiPageWikiLink Low-density_lipoprotein.
- Deramciclane wikiPageWikiLink Peritoneum.
- Deramciclane wikiPageWikiLink Pharmacokinetics.
- Deramciclane wikiPageWikiLink Phenylborneol.
- Deramciclane wikiPageWikiLink Post-translational_modification.
- Deramciclane wikiPageWikiLink Receptor_(biochemistry).
- Deramciclane wikiPageWikiLink Receptor_antagonist.
- Deramciclane wikiPageWikiLink Redox.
- Deramciclane wikiPageWikiLink Residence_time.
- Deramciclane wikiPageWikiLink Tiagabine.
- Deramciclane wikiPageWikiLink Tmax.
- Deramciclane wikiPageWikiLinkText "Deramciclane".
- Deramciclane wikiPageWikiLinkText "deramciclane".
- Deramciclane atcPrefix "none".
- Deramciclane c "20".
- Deramciclane casNumber "120444".
- Deramciclane chembl "2104698".
- Deramciclane chemspiderid "23498865".
- Deramciclane h "31".
- Deramciclane inchi "1".
- Deramciclane inchikey "NTGJQFUKCCRUPP-HMXCVIKNBP".
- Deramciclane iupacName "N,N-dimethyl-2-ethanamine".
- Deramciclane molecularWeight "301.466".
- Deramciclane n "1".
- Deramciclane o "1".
- Deramciclane pubchem "119590".
- Deramciclane smiles "C[C@@]12CC[C@@H]C[C@]2c3ccccc3".
- Deramciclane stdinchi "1".
- Deramciclane stdinchikey "NTGJQFUKCCRUPP-HMXCVIKNSA-N".
- Deramciclane synonyms "Deramciclane".
- Deramciclane unii "O5KFK61E74".
- Deramciclane verifiedfields "changed".
- Deramciclane verifiedrevid "444367226".
- Deramciclane watchedfields "changed".
- Deramciclane width "160".
- Deramciclane wikiPageUsesTemplate Template:Anticonvulsants.
- Deramciclane wikiPageUsesTemplate Template:Anxiolytics.
- Deramciclane wikiPageUsesTemplate Template:Cascite.
- Deramciclane wikiPageUsesTemplate Template:Chemspidercite.
- Deramciclane wikiPageUsesTemplate Template:Drugbox.
- Deramciclane wikiPageUsesTemplate Template:Ebicite.
- Deramciclane wikiPageUsesTemplate Template:Fdacite.
- Deramciclane wikiPageUsesTemplate Template:GABAergics.
- Deramciclane wikiPageUsesTemplate Template:Reflist.
- Deramciclane wikiPageUsesTemplate Template:Serotonergics.
- Deramciclane wikiPageUsesTemplate Template:Stdinchicite.
- Deramciclane subject Category:5-HT2A_antagonists.
- Deramciclane subject Category:GABA_reuptake_inhibitors.
- Deramciclane hypernym Drug.
- Deramciclane type ChemicalSubstance.
- Deramciclane type Drug.
- Deramciclane type Antagonist.
- Deramciclane type Anticonvulsant.
- Deramciclane type Chemical.
- Deramciclane type Drug.
- Deramciclane type Inhibitor.
- Deramciclane type ChemicalObject.
- Deramciclane type Thing.
- Deramciclane type Q8386.
- Deramciclane comment "Deramciclane (EGIS-3886) is a non-benzodiazepine-type anxiolytic drug to treat various types of anxiety disorders, which 40-80 million people in the world suffer from. Deramciclane is a unique alternative to current anxiolytics on the market because it has a novel chemical structure and target. It acts as an antagonist at the 5-HT2A receptor, as an inverse agonist at the 5-HT2C receptor, and as a GABA reuptake inhibitor.".
- Deramciclane label "Deramciclane".
- Deramciclane sameAs Q5261335.
- Deramciclane sameAs m.04f_fb1.