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- Depurination abstract "Depurination is a chemical reaction of purine deoxyribonucleosides, deoxyadenosine and deoxyguanosine, and ribonucleosides, adenosine or guanosine, in which the β-N-glycosidic bond is hydrolytically cleaved releasing a nucleic base, adenine or guanine, respectively. The second product of depurination of deoxyribonucleosides and ribonucleosides is sugar, 2’-deoxyribose and ribose, respectively. More complex compounds containing nucleoside residues, nucleotides and nucleic acids, also suffer from depurination. Deoxyribonucleosides and their derivatives are substantially more prone to depurination than their corresponding ribonucleoside counterparts. Loss of pyrimidine bases (Cytosine and Thymine) occurs by a similar mechanism, but at a substantially lower rate.When depurination occurs with DNA, it leads to the formation of apurinic site and results in an alteration of the structure. Studies estimate that as many as 5,000 purines are lost this way each day in a typical human cell. In cells, one of the main causes of depurination is the presence of endogenous metabolites undergoing chemical reactions. Apurinic sites in double-stranded DNA are efficiently repaired by portions of the base excision repair (BER) pathway. Depurinated bases in single-stranded DNA undergoing replication can lead to mutations, because in the absence of information from the complementary strand, BER can add an incorrect base at the apurinic site, resulting in either a transition or transversion mutation.Depurination is known to play a major role in cancer initiation.Hydrolytic depurination is one of the principal forms of damage to ancient DNA in fossil or subfossil material, since the base remains unrepaired. This results in both loss of information (the base sequence), and difficulties in recovery and in vitro replication of the damaged molecule by the polymerase chain reaction.".
- Depurination thumbnail Apurinic_Site.png?width=300.
- Depurination wikiPageExternalLink ?id=hTLSRQAACAAJ.
- Depurination wikiPageExternalLink ?id=i0Dfq8pzll8C.
- Depurination wikiPageExternalLink ?id=wNiwQgAACAAJ.
- Depurination wikiPageID "2629518".
- Depurination wikiPageLength "5686".
- Depurination wikiPageOutDegree "40".
- Depurination wikiPageRevisionID "606318007".
- Depurination wikiPageWikiLink AP_site.
- Depurination wikiPageWikiLink Adenine.
- Depurination wikiPageWikiLink Adenosine.
- Depurination wikiPageWikiLink Ancient_DNA.
- Depurination wikiPageWikiLink Anomer.
- Depurination wikiPageWikiLink Base_excision_repair.
- Depurination wikiPageWikiLink Category:DNA.
- Depurination wikiPageWikiLink Category:Genetics.
- Depurination wikiPageWikiLink Category:Mutation.
- Depurination wikiPageWikiLink Cytosine.
- Depurination wikiPageWikiLink DNA.
- Depurination wikiPageWikiLink DNA_replication.
- Depurination wikiPageWikiLink Deoxyadenosine.
- Depurination wikiPageWikiLink Deoxyguanosine.
- Depurination wikiPageWikiLink Deoxyribonucleoside.
- Depurination wikiPageWikiLink Deoxyribose.
- Depurination wikiPageWikiLink Garland_Science.
- Depurination wikiPageWikiLink Glycosidic_bond.
- Depurination wikiPageWikiLink Guanine.
- Depurination wikiPageWikiLink Guanosine.
- Depurination wikiPageWikiLink Hydrolysis.
- Depurination wikiPageWikiLink Leaving_group.
- Depurination wikiPageWikiLink McGraw-Hill_Education.
- Depurination wikiPageWikiLink Mutation.
- Depurination wikiPageWikiLink Nucleic_acid.
- Depurination wikiPageWikiLink Nucleophilic_substitution.
- Depurination wikiPageWikiLink Nucleotide.
- Depurination wikiPageWikiLink Oligonucleotide.
- Depurination wikiPageWikiLink Oligonucleotide_synthesis.
- Depurination wikiPageWikiLink Polymerase_chain_reaction.
- Depurination wikiPageWikiLink Purine.
- Depurination wikiPageWikiLink Pyrimidine.
- Depurination wikiPageWikiLink Ribonucleoside.
- Depurination wikiPageWikiLink Ribose.
- Depurination wikiPageWikiLink Thymine.
- Depurination wikiPageWikiLink Transition_(genetics).
- Depurination wikiPageWikiLink Transversion.
- Depurination wikiPageWikiLink File:Apurinic_Site.png.
- Depurination wikiPageWikiLinkText "Depurination".
- Depurination wikiPageWikiLinkText "depurinate".
- Depurination wikiPageWikiLinkText "depurinated".
- Depurination wikiPageWikiLinkText "depurination".
- Depurination wikiPageUsesTemplate Template:Cite_book.
- Depurination wikiPageUsesTemplate Template:Reflist.
- Depurination subject Category:DNA.
- Depurination subject Category:Genetics.
- Depurination subject Category:Mutation.
- Depurination hypernym Reaction.
- Depurination type Disease.
- Depurination comment "Depurination is a chemical reaction of purine deoxyribonucleosides, deoxyadenosine and deoxyguanosine, and ribonucleosides, adenosine or guanosine, in which the β-N-glycosidic bond is hydrolytically cleaved releasing a nucleic base, adenine or guanine, respectively. The second product of depurination of deoxyribonucleosides and ribonucleosides is sugar, 2’-deoxyribose and ribose, respectively.".
- Depurination label "Depurination".
- Depurination sameAs Q903582.
- Depurination sameAs Despurinització.
- Depurination sameAs Depurinierung.
- Depurination sameAs Dépurination_et_dépyrimidination.
- Depurination sameAs Depurinazione.
- Depurination sameAs Depurynacja.
- Depurination sameAs m.07sx5g.
- Depurination sameAs Q903582.
- Depurination wasDerivedFrom Depurination?oldid=606318007.
- Depurination depiction Apurinic_Site.png.
- Depurination isPrimaryTopicOf Depurination.