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- Deoxyribonuclease_I abstract "Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1.DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis.DNase I binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. The function of this interaction is unclear. However, since actin-bound DNase I is enzymatically inactive, the DNase-actin complex might be a storage form of DNase I that prevents damage of the genetic information.This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene, as well as factor inactivating its enzyme product, have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.".
- Deoxyribonuclease_I entrezgene "1773".
- Deoxyribonuclease_I wikiPageID "5507057".
- Deoxyribonuclease_I wikiPageLength "10972".
- Deoxyribonuclease_I wikiPageOutDegree "17".
- Deoxyribonuclease_I wikiPageRevisionID "701364794".
- Deoxyribonuclease_I wikiPageWikiLink Actin.
- Deoxyribonuclease_I wikiPageWikiLink Apoptosis.
- Deoxyribonuclease_I wikiPageWikiLink Category:EC_3.1.21.
- Deoxyribonuclease_I wikiPageWikiLink Chromatin.
- Deoxyribonuclease_I wikiPageWikiLink Cystic_fibrosis.
- Deoxyribonuclease_I wikiPageWikiLink Cytoskeleton.
- Deoxyribonuclease_I wikiPageWikiLink DNA.
- Deoxyribonuclease_I wikiPageWikiLink Deoxyribonuclease.
- Deoxyribonuclease_I wikiPageWikiLink Dissociation_constant.
- Deoxyribonuclease_I wikiPageWikiLink Dornase_alfa.
- Deoxyribonuclease_I wikiPageWikiLink Endonuclease.
- Deoxyribonuclease_I wikiPageWikiLink Hypersensitive_site.
- Deoxyribonuclease_I wikiPageWikiLink Nuclease.
- Deoxyribonuclease_I wikiPageWikiLink Nucleotide.
- Deoxyribonuclease_I wikiPageWikiLink Pyrimidine.
- Deoxyribonuclease_I wikiPageWikiLinkText "DNAse I".
- Deoxyribonuclease_I wikiPageWikiLinkText "DNAse1".
- Deoxyribonuclease_I wikiPageWikiLinkText "DNase I".
- Deoxyribonuclease_I wikiPageWikiLinkText "DNaseI".
- Deoxyribonuclease_I wikiPageWikiLinkText "Deoxyribonuclease I".
- Deoxyribonuclease_I wikiPageWikiLinkText "deoxyribonuclease I".
- Deoxyribonuclease_I wikiPageWikiLinkText "dnase I".
- Deoxyribonuclease_I requireManualInspection "no".
- Deoxyribonuclease_I summaryText "This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene, as well as factor inactivating its enzyme product, have been associated with systemic lupus erythematosus , an autoimmune disease. A recombinant form of this protein is used to treat one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.".
- Deoxyribonuclease_I updateCitations "yes".
- Deoxyribonuclease_I updatePage "yes".
- Deoxyribonuclease_I updateProteinBox "yes".
- Deoxyribonuclease_I updateSummary "yes".
- Deoxyribonuclease_I wikiPageUsesTemplate Template:Cite_journal.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:Enzymes.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:Esterases.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:MeshName.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:PBB.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:PBB_Controls.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:PBB_Further_reading.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:PBB_Summary.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:Portal_bar.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:Refbegin.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:Refend.
- Deoxyribonuclease_I wikiPageUsesTemplate Template:Reflist.
- Deoxyribonuclease_I subject Category:EC_3.1.21.
- Deoxyribonuclease_I hypernym Endonuclease.
- Deoxyribonuclease_I type Biomolecule.
- Deoxyribonuclease_I type Protein.
- Deoxyribonuclease_I type Redirect.
- Deoxyribonuclease_I type Thing.
- Deoxyribonuclease_I type Q206229.
- Deoxyribonuclease_I type Q8054.
- Deoxyribonuclease_I comment "Deoxyribonuclease I (usually called DNase I), is an endonuclease coded by the human gene DNASE1.DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin.".
- Deoxyribonuclease_I label "Deoxyribonuclease I".
- Deoxyribonuclease_I sameAs Q14901483.
- Deoxyribonuclease_I sameAs Deoksyrybonukleaza_I.
- Deoxyribonuclease_I sameAs m.02vkgy5.
- Deoxyribonuclease_I sameAs Дезоксирибонуклеаза_I.
- Deoxyribonuclease_I sameAs Dezoksiribonukleaza_I.
- Deoxyribonuclease_I sameAs Dezoksiribonukleaza_I.
- Deoxyribonuclease_I sameAs Q14901483.
- Deoxyribonuclease_I wasDerivedFrom Deoxyribonuclease_I?oldid=701364794.
- Deoxyribonuclease_I isPrimaryTopicOf Deoxyribonuclease_I.