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- Deoxygedunin abstract "Deoxygedunin, or 14,15-deoxygedunin, is a naturally-occurring tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica), a plant that has been used in India since ancient times as a remedy for various ailments. Deoxygedunin has been found to act as a potent, selective, small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF). It produces TrkB-dependent neurotrophic and neuroprotective effects in mice and enhances learning processes. In addition, deoxygedunin evokes rapid TrkB-dependent antidepressant-like effects in the forced swim test, an animal model of depression, similarly to 7,8-dihydroxyflavone (7,8-DHF) and ketamine, and notably with a greater potency than 7,8-DHF. The compound was discovered by the same group that identified 7,8-DHF and N-acetylserotonin as TrkB agonists.With intraperitoneal injection to mice, deoxygedunin crosses the blood-brain-barrier into the central nervous system and possesses a long duration of action, with onset of action at 2 hours post-administration and peaking between 4–8 hours. Relative to 7,8-DHF, deoxygedunin has weaker binding affinity for TrkB (Kd = 1.4 µM). However, it is more potent than 7,8-DHF in vivo with intraperitoneal injection in multiple assays. Deoxygedunin has also been found to be orally and topically active. Unfortunately, the compound, in contrast to 7,8-DHF, has poor water solubility, and hence its bioavailability, especially oral, may be suboptimal. The researchers who discovered deoxygedunin expressed that they were attempting to find analogues with improved water solubility that retained the biological activity of deoxygedunin, but, as of 2016, there appear to have been no subsequent reports on this effort since the original paper (2010) was published. They also stated in the paper that 7,8-DHF has a simpler chemical structure and that the flavonoids were easier to modify for improved biological effects than the gedunins.Similarly to gedunin, a closely structurally related compound also found in Azadirachta indica, deoxygedunin has additionally been found to activate HSF1 and induce Hsp70, and was observed to possess neuroprotective effects in a model of Huntington's disease.".
- Deoxygedunin atcPrefix "None".
- Deoxygedunin casNumber "21963-95-1".
- Deoxygedunin iupacName "[1-(Furan-3-yl)-4b,7,7,10a,12a-pentamethyl-3,8-dioxo-5,6,6a,10b,11,12-hexahydro-1H-naphtho[2,1-f]isochromen-5-yl] acetate".
- Deoxygedunin pubchem "328942".
- Deoxygedunin thumbnail Deoxygedunin.svg?width=300.
- Deoxygedunin wikiPageID "49040098".
- Deoxygedunin wikiPageLength "8057".
- Deoxygedunin wikiPageOutDegree "49".
- Deoxygedunin wikiPageRevisionID "698953765".
- Deoxygedunin wikiPageWikiLink 4-Dimethylamino-7,8-dihydroxyflavone.
- Deoxygedunin wikiPageWikiLink 7,8-Dihydroxyflavone.
- Deoxygedunin wikiPageWikiLink ANA-12.
- Deoxygedunin wikiPageWikiLink Agonist.
- Deoxygedunin wikiPageWikiLink Antidepressant.
- Deoxygedunin wikiPageWikiLink Aqueous_solution.
- Deoxygedunin wikiPageWikiLink Azadirachta_indica.
- Deoxygedunin wikiPageWikiLink Behavioural_despair_test.
- Deoxygedunin wikiPageWikiLink Bioavailability.
- Deoxygedunin wikiPageWikiLink Blood–brain_barrier.
- Deoxygedunin wikiPageWikiLink Brain-derived_neurotrophic_factor.
- Deoxygedunin wikiPageWikiLink Category:Antidepressants.
- Deoxygedunin wikiPageWikiLink Category:Neuroprotective_agents.
- Deoxygedunin wikiPageWikiLink Category:Nootropics.
- Deoxygedunin wikiPageWikiLink Category:Triterpenes.
- Deoxygedunin wikiPageWikiLink Category:TrkB_agonists.
- Deoxygedunin wikiPageWikiLink Central_nervous_system.
- Deoxygedunin wikiPageWikiLink Chemical_structure.
- Deoxygedunin wikiPageWikiLink Cyclotraxin_B.
- Deoxygedunin wikiPageWikiLink Depression_(mood).
- Deoxygedunin wikiPageWikiLink Diosmetin.
- Deoxygedunin wikiPageWikiLink Flavonoid.
- Deoxygedunin wikiPageWikiLink Gedunin.
- Deoxygedunin wikiPageWikiLink HIOC.
- Deoxygedunin wikiPageWikiLink HSF1.
- Deoxygedunin wikiPageWikiLink Hsp70.
- Deoxygedunin wikiPageWikiLink Huntingtons_disease.
- Deoxygedunin wikiPageWikiLink India.
- Deoxygedunin wikiPageWikiLink Intraperitoneal_injection.
- Deoxygedunin wikiPageWikiLink Ketamine.
- Deoxygedunin wikiPageWikiLink LM22A-4.
- Deoxygedunin wikiPageWikiLink Ligand_(biochemistry).
- Deoxygedunin wikiPageWikiLink Model_organism.
- Deoxygedunin wikiPageWikiLink N-Acetylserotonin.
- Deoxygedunin wikiPageWikiLink Natural_product.
- Deoxygedunin wikiPageWikiLink Neuroprotection.
- Deoxygedunin wikiPageWikiLink Neurotrophin.
- Deoxygedunin wikiPageWikiLink Norwogonin.
- Deoxygedunin wikiPageWikiLink Oral_administration.
- Deoxygedunin wikiPageWikiLink Receptor_(biochemistry).
- Deoxygedunin wikiPageWikiLink Small_molecule.
- Deoxygedunin wikiPageWikiLink Tetranortriterpenoid.
- Deoxygedunin wikiPageWikiLink Topical_medication.
- Deoxygedunin wikiPageWikiLink Tropomyosin_receptor_kinase_B.
- Deoxygedunin wikiPageWikiLinkText "Deoxygedunin".
- Deoxygedunin atcPrefix "None".
- Deoxygedunin c "28".
- Deoxygedunin casNumber "21963".
- Deoxygedunin chemspiderid "10341832".
- Deoxygedunin h "34".
- Deoxygedunin inchi "InChI=1S/C28H34O6/c1-1633-22-13-19-25218-11-2618-7-10-272014-2334-2417-9-12-32-15-17/h8-9,11-12,14-15,18-19,22,24H,7,10,13H2,1-6H3".
- Deoxygedunin inchikey "VOUDTVRGPAGHGA-UHFFFAOYSA-N".
- Deoxygedunin iupacName "[1--4b,7,7,10a,12a-pentamethyl-3,8-dioxo-5,6,6a,10b,11,12-hexahydro-1H-naphtho[2,1-f]isochromen-5-yl] acetate".
- Deoxygedunin molecularWeight "466.56596".
- Deoxygedunin o "6".
- Deoxygedunin pubchem "328942".
- Deoxygedunin smiles "CCOC1CC2CC".
- Deoxygedunin stdinchi "1".
- Deoxygedunin stdinchikey "VOUDTVRGPAGHGA-UHFFFAOYSA-N".
- Deoxygedunin synonyms "1415".
- Deoxygedunin wikiPageUsesTemplate Template:Drugbox.
- Deoxygedunin wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- Deoxygedunin wikiPageUsesTemplate Template:Neurotrophinergics.
- Deoxygedunin wikiPageUsesTemplate Template:Reflist.
- Deoxygedunin subject Category:Antidepressants.
- Deoxygedunin subject Category:Neuroprotective_agents.
- Deoxygedunin subject Category:Nootropics.
- Deoxygedunin subject Category:Triterpenes.
- Deoxygedunin subject Category:TrkB_agonists.
- Deoxygedunin hypernym Tetranortriterpenoid.
- Deoxygedunin type ChemicalSubstance.
- Deoxygedunin type Drug.
- Deoxygedunin type ChemicalObject.
- Deoxygedunin type Thing.
- Deoxygedunin type Q8386.
- Deoxygedunin comment "Deoxygedunin, or 14,15-deoxygedunin, is a naturally-occurring tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica), a plant that has been used in India since ancient times as a remedy for various ailments. Deoxygedunin has been found to act as a potent, selective, small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF). It produces TrkB-dependent neurotrophic and neuroprotective effects in mice and enhances learning processes.".
- Deoxygedunin label "Deoxygedunin".
- Deoxygedunin wasDerivedFrom Deoxygedunin?oldid=698953765.
- Deoxygedunin depiction Deoxygedunin.svg.
- Deoxygedunin isPrimaryTopicOf Deoxygedunin.