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- De_novo_protein_structure_prediction abstract "In computational biology, de novo protein structure prediction refers to an algorithmic process by which protein tertiary structure is predicted from its amino acid primary sequence. The problem itself has occupied leading scientists for decades while still remaining unsolved. According to Science, the problem remains one of the top 125 outstanding issues in modern science. At present, some of the most successful methods have a reasonable probability of predicting the folds of small, single-domain proteins within 1.5 angstroms over the entire structure.De novo methods tend to require vast computational resources, and have thus only been carried out for relatively small proteins. De novo protein structure modeling is distinguished from Template-based modeling (TBM) by the fact that no solved homolog to the protein of interest is used, making efforts to predict protein structure from amino acid sequence exceedingly difficult. Prediction of protein structure de novo for larger proteins will require better algorithms and larger computational resources such as those afforded by either powerful supercomputers (such as Blue Gene or MDGRAPE-3) or distributed computing projects (such as Folding@home, Rosetta@home, the Human Proteome Folding Project, or Nutritious Rice for the World). Although computational barriers are vast, the potential benefits of structural genomics (by predicted or experimental methods) to fields such as medicine and drug design make de novo structure prediction an active research field.".
- De_novo_protein_structure_prediction wikiPageExternalLink expasy.org.
- De_novo_protein_structure_prediction wikiPageExternalLink viewHpf2Research.do.
- De_novo_protein_structure_prediction wikiPageExternalLink portal.
- De_novo_protein_structure_prediction wikiPageExternalLink folding.stanford.edu.
- De_novo_protein_structure_prediction wikiPageExternalLink predictioncenter.org.
- De_novo_protein_structure_prediction wikiPageExternalLink swissprot.
- De_novo_protein_structure_prediction wikiPageExternalLink pdb.
- De_novo_protein_structure_prediction wikiPageID "9378673".
- De_novo_protein_structure_prediction wikiPageLength "18630".
- De_novo_protein_structure_prediction wikiPageOutDegree "25".
- De_novo_protein_structure_prediction wikiPageRevisionID "701221329".
- De_novo_protein_structure_prediction wikiPageWikiLink Biomolecular_structure.
- De_novo_protein_structure_prediction wikiPageWikiLink CASP.
- De_novo_protein_structure_prediction wikiPageWikiLink Category:Bioinformatics.
- De_novo_protein_structure_prediction wikiPageWikiLink Category:Protein_methods.
- De_novo_protein_structure_prediction wikiPageWikiLink Category:Protein_structure.
- De_novo_protein_structure_prediction wikiPageWikiLink Christian_B._Anfinsen.
- De_novo_protein_structure_prediction wikiPageWikiLink Computational_biology.
- De_novo_protein_structure_prediction wikiPageWikiLink Configuration_space.
- De_novo_protein_structure_prediction wikiPageWikiLink David_Baker_(biochemist).
- De_novo_protein_structure_prediction wikiPageWikiLink Folding@home.
- De_novo_protein_structure_prediction wikiPageWikiLink Human_Proteome_Folding_Project.
- De_novo_protein_structure_prediction wikiPageWikiLink List_of_protein_structure_prediction_software.
- De_novo_protein_structure_prediction wikiPageWikiLink Markov_chain_Monte_Carlo.
- De_novo_protein_structure_prediction wikiPageWikiLink Nutritious_Rice_for_the_World.
- De_novo_protein_structure_prediction wikiPageWikiLink Protein_design.
- De_novo_protein_structure_prediction wikiPageWikiLink Protein_folding.
- De_novo_protein_structure_prediction wikiPageWikiLink Protein_structure_prediction.
- De_novo_protein_structure_prediction wikiPageWikiLink Richard_Bonneau.
- De_novo_protein_structure_prediction wikiPageWikiLink Rosetta@home.
- De_novo_protein_structure_prediction wikiPageWikiLink Science_(journal).
- De_novo_protein_structure_prediction wikiPageWikiLink Threading_(protein_sequence).
- De_novo_protein_structure_prediction wikiPageWikiLink X-ray_crystallography.
- De_novo_protein_structure_prediction wikiPageWikiLink File:Energy_and_entropy_recreation_diagram_PNG.png.
- De_novo_protein_structure_prediction wikiPageWikiLink File:T0281-bakerprediction_overlay.png.
- De_novo_protein_structure_prediction wikiPageWikiLinkText "''De novo'' protein structure prediction".
- De_novo_protein_structure_prediction wikiPageWikiLinkText "''ab initio'' modeling".
- De_novo_protein_structure_prediction wikiPageWikiLinkText "''de novo'' protein structure prediction".
- De_novo_protein_structure_prediction wikiPageWikiLinkText "De novo protein structure prediction".
- De_novo_protein_structure_prediction wikiPageWikiLinkText "ab initio prediction".
- De_novo_protein_structure_prediction wikiPageWikiLinkText "ab initio protein structure prediction".
- De_novo_protein_structure_prediction wikiPageWikiLinkText "de novo protein structure prediction".
- De_novo_protein_structure_prediction wikiPageWikiLinkText "de novo structure prediction".
- De_novo_protein_structure_prediction wikiPageWikiLinkText "de novo".
- De_novo_protein_structure_prediction wikiPageUsesTemplate Template:Reflist.
- De_novo_protein_structure_prediction subject Category:Bioinformatics.
- De_novo_protein_structure_prediction subject Category:Protein_methods.
- De_novo_protein_structure_prediction subject Category:Protein_structure.
- De_novo_protein_structure_prediction type Biophysic.
- De_novo_protein_structure_prediction type Biostatistic.
- De_novo_protein_structure_prediction type Method.
- De_novo_protein_structure_prediction comment "In computational biology, de novo protein structure prediction refers to an algorithmic process by which protein tertiary structure is predicted from its amino acid primary sequence. The problem itself has occupied leading scientists for decades while still remaining unsolved. According to Science, the problem remains one of the top 125 outstanding issues in modern science.".
- De_novo_protein_structure_prediction label "De novo protein structure prediction".
- De_novo_protein_structure_prediction sameAs Q5244958.
- De_novo_protein_structure_prediction sameAs m.0286hxn.
- De_novo_protein_structure_prediction sameAs Q5244958.
- De_novo_protein_structure_prediction wasDerivedFrom De_novo_protein_structure_prediction?oldid=701221329.
- De_novo_protein_structure_prediction isPrimaryTopicOf De_novo_protein_structure_prediction.