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- DPA-714 abstract "DPA-714 or N,N-diethyl-2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide is a selective ligand for the translocator protein (TSPO) currently under evaluation for several clinical applications. For this reason, a practical, multigram synthetic route for its preparation has been described.The binding affinity of DPA-714 for TSPO is reported as Ki = 7.0 ± 0.4 nM.[18F]DPA-714 is currently under investigation as a potential radiopharmaceutical for imaging TSPO in living systems using positron emission tomography (PET). DPA-714, along with other members of the DPA class of TSPO ligands, has been shown to decrease microglial activation and increase neuronal survival in a quinolinic acid rat model of excitotoxic neurodegeneration, suggesting potential neuroprotective effects.".
- DPA-714 casNumber "958233-07-3".
- DPA-714 iupacName "N,N-diethyl-2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide".
- DPA-714 wikiPageID "36064475".
- DPA-714 wikiPageLength "4447".
- DPA-714 wikiPageOutDegree "11".
- DPA-714 wikiPageRevisionID "679450896".
- DPA-714 wikiPageWikiLink Category:Pyrazolopyrimidines.
- DPA-714 wikiPageWikiLink Category:TSPO_ligands.
- DPA-714 wikiPageWikiLink DPA-713.
- DPA-714 wikiPageWikiLink Excitotoxicity.
- DPA-714 wikiPageWikiLink Ligand_(biochemistry).
- DPA-714 wikiPageWikiLink Medicinal_radiocompounds.
- DPA-714 wikiPageWikiLink Neurodegeneration.
- DPA-714 wikiPageWikiLink Positron_emission_tomography.
- DPA-714 wikiPageWikiLink Quinolinic_acid.
- DPA-714 wikiPageWikiLink Translocator_protein.
- DPA-714 wikiPageWikiLinkText "DPA-714".
- DPA-714 c "22".
- DPA-714 casNumber "958233".
- DPA-714 f "1".
- DPA-714 h "27".
- DPA-714 iupacName "N,N-diethyl-2-[4-phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide".
- DPA-714 molecularWeight "398.47".
- DPA-714 n "4".
- DPA-714 o "2".
- DPA-714 wikiPageUsesTemplate Template:Drugbox.
- DPA-714 wikiPageUsesTemplate Template:Reflist.
- DPA-714 subject Category:Pyrazolopyrimidines.
- DPA-714 subject Category:TSPO_ligands.
- DPA-714 hypernym Ligand.
- DPA-714 type ChemicalSubstance.
- DPA-714 type Drug.
- DPA-714 type Chemical.
- DPA-714 type Heterocycle.
- DPA-714 type ChemicalObject.
- DPA-714 type Thing.
- DPA-714 type Q8386.
- DPA-714 comment "DPA-714 or N,N-diethyl-2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-acetamide is a selective ligand for the translocator protein (TSPO) currently under evaluation for several clinical applications.".
- DPA-714 label "DPA-714".
- DPA-714 sameAs Q5205913.
- DPA-714 sameAs m.0k0tnhk.
- DPA-714 sameAs Q5205913.
- DPA-714 wasDerivedFrom DPA-714?oldid=679450896.
- DPA-714 isPrimaryTopicOf DPA-714.