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- DOV-102,677 abstract "DOV-102,677 is a psychoactive drug being developed by Merck and is currently in clinical trials. It is a so-called triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). It is the (−)-enantiomer of DOV-216,303, and its (+)-enantiomer is DOV-21,947 (amitifadine).Instead of being developed for depression, DOV-102,677 is being developed for the treatment of alcoholism.IC50 values for the SERT, NET and DAT are 129 nM, 103 nM, and 133 nM.DOV-102,677 (20 mg/kg IP) increased extracellular levels of dopamine and serotonin in the prefrontal cortex to 320 and 280% above baseline 100 min after administration. Dopamine levels were stably increased for the duration (240 min) of the study, but serotonin levels declined to baseline by 200 min after administration. Norepinephrine levels increased linearly to a maximum of 348% at 240 min post-dosing.".
- DOV-102,677 iupacName "(5R)-5-(3,4-dichlorophenyl)bicyclo[3.1.0]hexane".
- DOV-102,677 pubchem "11637190".
- DOV-102,677 thumbnail DOV-102677.svg?width=300.
- DOV-102,677 wikiPageID "22604153".
- DOV-102,677 wikiPageLength "3578".
- DOV-102,677 wikiPageOutDegree "18".
- DOV-102,677 wikiPageRevisionID "705006388".
- DOV-102,677 wikiPageWikiLink Alcoholism.
- DOV-102,677 wikiPageWikiLink Amitifadine.
- DOV-102,677 wikiPageWikiLink Category:Chloroarenes.
- DOV-102,677 wikiPageWikiLink Category:Cyclopropanes.
- DOV-102,677 wikiPageWikiLink Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- DOV-102,677 wikiPageWikiLink Clinical_trial.
- DOV-102,677 wikiPageWikiLink DOV-216,303.
- DOV-102,677 wikiPageWikiLink Depression_(mood).
- DOV-102,677 wikiPageWikiLink Dopamine_transporter.
- DOV-102,677 wikiPageWikiLink Drug_development.
- DOV-102,677 wikiPageWikiLink IC50.
- DOV-102,677 wikiPageWikiLink Merck_&_Co..
- DOV-102,677 wikiPageWikiLink Norepinephrine_transporter.
- DOV-102,677 wikiPageWikiLink Psychoactive_drug.
- DOV-102,677 wikiPageWikiLink Serotonin_transporter.
- DOV-102,677 wikiPageWikiLink Serotonin–norepinephrine–dopamine_reuptake_inhibitor.
- DOV-102,677 wikiPageWikiLink File:DOV_stereochemistry.svg.
- DOV-102,677 wikiPageWikiLinkText "DOV-102,677".
- DOV-102,677 c "11".
- DOV-102,677 cl "2".
- DOV-102,677 h "11".
- DOV-102,677 iupacName "-5".
- DOV-102,677 legalStatus "Investigational New Medicine".
- DOV-102,677 molecularWeight "228.118".
- DOV-102,677 n "1".
- DOV-102,677 pubchem "11637190".
- DOV-102,677 smiles "C1[C@]CC=CCl".
- DOV-102,677 verifiedrevid "407870872".
- DOV-102,677 watchedfields "changed".
- DOV-102,677 width "170".
- DOV-102,677 wikiPageUsesTemplate Template:Adrenergics.
- DOV-102,677 wikiPageUsesTemplate Template:Clear_left.
- DOV-102,677 wikiPageUsesTemplate Template:Dopaminergics.
- DOV-102,677 wikiPageUsesTemplate Template:Drugbox.
- DOV-102,677 wikiPageUsesTemplate Template:Drugs_used_in_addictive_disorders.
- DOV-102,677 wikiPageUsesTemplate Template:Nervous-system-drug-stub.
- DOV-102,677 wikiPageUsesTemplate Template:Reflist.
- DOV-102,677 wikiPageUsesTemplate Template:Serotonergics.
- DOV-102,677 subject Category:Chloroarenes.
- DOV-102,677 subject Category:Cyclopropanes.
- DOV-102,677 subject Category:Serotonin-norepinephrine-dopamine_reuptake_inhibitors.
- DOV-102,677 hypernym Drug.
- DOV-102,677 type ChemicalSubstance.
- DOV-102,677 type Drug.
- DOV-102,677 type Chemical.
- DOV-102,677 type Drug.
- DOV-102,677 type Inhibitor.
- DOV-102,677 type Organohalide.
- DOV-102,677 type Organohalide.
- DOV-102,677 type ChemicalObject.
- DOV-102,677 type Thing.
- DOV-102,677 type Q8386.
- DOV-102,677 comment "DOV-102,677 is a psychoactive drug being developed by Merck and is currently in clinical trials. It is a so-called triple reuptake inhibitor (TRI), or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).".
- DOV-102,677 label "DOV-102,677".
- DOV-102,677 sameAs Q5205903.
- DOV-102,677 sameAs m.05zr15j.
- DOV-102,677 sameAs Q5205903.
- DOV-102,677 wasDerivedFrom DOV-102,677?oldid=705006388.
- DOV-102,677 depiction DOV-102677.svg.
- DOV-102,677 isPrimaryTopicOf DOV-102,677.